Effects of kisspeptin on the maturation of human ovarian primordial follicles in vitro
At this time, with advances in medical science, many cancers and chronic diseases are treatable, but one of their side effects is infertility. Some women also want to delay pregnancy for personal reasons. There has been some evidence that kisspeptin activates broad signals by binding to its receptor...
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| Veröffentlicht in: | Zygote (Cambridge) 2024-02, Vol.32 (1), p.66-70 |
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| creator | Rezaei-Tazangi, Fatemeh Kooshesh, Leila Tayyebiazar, Ali Taghizabet, Neda Tavakoli, Anahita Hassanpour, Ashraf Aliakbari, Fereshteh Kharazinejad, Ebrahim Sharifi, Ali-Mohammad |
| description | At this time, with advances in medical science, many cancers and chronic diseases are treatable, but one of their side effects is infertility. Some women also want to delay pregnancy for personal reasons. There has been some evidence that kisspeptin activates broad signals by binding to its receptor, suggesting that the role of kisspeptin in direct control of ovarian function includes follicle growth and steroid production. In this study, the effect of kisspeptin on improving the quality and results for human ovarian follicles was investigated. A section of ovary was removed laparoscopically from women between 20 and 35 years of age (
= 12). Pieces were divided randomly into two groups, control and treatment (with 1 μM kisspeptin). Real-time PCR was performed for
,
and
gene expression assessments. Western blotting was carried out to measure AKT and FOXO3a protein expression. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's test; means were considered significantly different at a
-value < 0.05. During treatment with the kisspeptin group, maturity genes are expressed. Therefore, kisspeptin is an effective substance to improve the quality of the human ovarian medium as it increases the maturity of follicles. |
| doi_str_mv | 10.1017/S0967199423000527 |
| format | Article |
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= 12). Pieces were divided randomly into two groups, control and treatment (with 1 μM kisspeptin). Real-time PCR was performed for
,
and
gene expression assessments. Western blotting was carried out to measure AKT and FOXO3a protein expression. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's test; means were considered significantly different at a
-value < 0.05. During treatment with the kisspeptin group, maturity genes are expressed. Therefore, kisspeptin is an effective substance to improve the quality of the human ovarian medium as it increases the maturity of follicles.</description><identifier>ISSN: 0967-1994</identifier><identifier>EISSN: 1469-8730</identifier><identifier>DOI: 10.1017/S0967199423000527</identifier><identifier>PMID: 38099429</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>AKT protein ; Antibodies ; Chemotherapy ; Eggs ; Follicles ; FOXO3 protein ; Gene expression ; Health services ; Infertility ; Kinases ; Kiss1 protein ; Medical science ; Ovaries ; Ovulation ; Penicillin ; Proteins ; Puberty ; Reproductive status ; Side effects ; Signal quality ; TOR protein ; Transplants & implants ; Variance analysis ; Western blotting</subject><ispartof>Zygote (Cambridge), 2024-02, Vol.32 (1), p.66-70</ispartof><rights>The Author(s), 2023. Published by Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c281t-962f10f8640fc4ce6fb11113b7e1b9ead995c7f547d64842fe8c8066f97fe5263</cites><orcidid>0000-0003-2262-1302 ; 0000-0003-1402-6482</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38099429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rezaei-Tazangi, Fatemeh</creatorcontrib><creatorcontrib>Kooshesh, Leila</creatorcontrib><creatorcontrib>Tayyebiazar, Ali</creatorcontrib><creatorcontrib>Taghizabet, Neda</creatorcontrib><creatorcontrib>Tavakoli, Anahita</creatorcontrib><creatorcontrib>Hassanpour, Ashraf</creatorcontrib><creatorcontrib>Aliakbari, Fereshteh</creatorcontrib><creatorcontrib>Kharazinejad, Ebrahim</creatorcontrib><creatorcontrib>Sharifi, Ali-Mohammad</creatorcontrib><title>Effects of kisspeptin on the maturation of human ovarian primordial follicles in vitro</title><title>Zygote (Cambridge)</title><addtitle>Zygote</addtitle><description>At this time, with advances in medical science, many cancers and chronic diseases are treatable, but one of their side effects is infertility. Some women also want to delay pregnancy for personal reasons. There has been some evidence that kisspeptin activates broad signals by binding to its receptor, suggesting that the role of kisspeptin in direct control of ovarian function includes follicle growth and steroid production. In this study, the effect of kisspeptin on improving the quality and results for human ovarian follicles was investigated. A section of ovary was removed laparoscopically from women between 20 and 35 years of age (
= 12). Pieces were divided randomly into two groups, control and treatment (with 1 μM kisspeptin). Real-time PCR was performed for
,
and
gene expression assessments. Western blotting was carried out to measure AKT and FOXO3a protein expression. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's test; means were considered significantly different at a
-value < 0.05. During treatment with the kisspeptin group, maturity genes are expressed. Therefore, kisspeptin is an effective substance to improve the quality of the human ovarian medium as it increases the maturity of follicles.</description><subject>AKT protein</subject><subject>Antibodies</subject><subject>Chemotherapy</subject><subject>Eggs</subject><subject>Follicles</subject><subject>FOXO3 protein</subject><subject>Gene expression</subject><subject>Health services</subject><subject>Infertility</subject><subject>Kinases</subject><subject>Kiss1 protein</subject><subject>Medical science</subject><subject>Ovaries</subject><subject>Ovulation</subject><subject>Penicillin</subject><subject>Proteins</subject><subject>Puberty</subject><subject>Reproductive status</subject><subject>Side effects</subject><subject>Signal quality</subject><subject>TOR protein</subject><subject>Transplants & implants</subject><subject>Variance analysis</subject><subject>Western blotting</subject><issn>0967-1994</issn><issn>1469-8730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplUEtLxDAQDqK46-oP8CIFL16qSZrmcRRZH7Dgwce1pGnCZm2bmqQL_ntTdvWgc5kZvgczHwDnCF4jiNjNCxSUISEILiCEJWYHYI4IFTlnBTwE8wnOJ3wGTkLYJA5jghyDWcHhpBJz8L40RqsYMmeyDxvCoIdo-8z1WVzrrJNx9DLatCZ8PXYyDVvpbeqDt53zjZVtZlzbWtXqkCXp1kbvTsGRkW3QZ_u-AG_3y9e7x3z1_PB0d7vKFeYo5oJig6DhlECjiNLU1ChVUTONaqFlI0SpmCkJayjhBBvNFYeUGsGMLjEtFuBq5zt49znqEKvOBqXbVvbajaHCAmJBCSlhol7-oW7c6Pt0XVUghBnkMMW2AGjHUt6F4LWppj-l_6oQrKbQq3-hJ83F3nmsO938Kn5SLr4BkDh8DA</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Rezaei-Tazangi, Fatemeh</creator><creator>Kooshesh, Leila</creator><creator>Tayyebiazar, Ali</creator><creator>Taghizabet, Neda</creator><creator>Tavakoli, Anahita</creator><creator>Hassanpour, Ashraf</creator><creator>Aliakbari, Fereshteh</creator><creator>Kharazinejad, Ebrahim</creator><creator>Sharifi, Ali-Mohammad</creator><general>Cambridge University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2262-1302</orcidid><orcidid>https://orcid.org/0000-0003-1402-6482</orcidid></search><sort><creationdate>20240201</creationdate><title>Effects of kisspeptin on the maturation of human ovarian primordial follicles in vitro</title><author>Rezaei-Tazangi, Fatemeh ; 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Some women also want to delay pregnancy for personal reasons. There has been some evidence that kisspeptin activates broad signals by binding to its receptor, suggesting that the role of kisspeptin in direct control of ovarian function includes follicle growth and steroid production. In this study, the effect of kisspeptin on improving the quality and results for human ovarian follicles was investigated. A section of ovary was removed laparoscopically from women between 20 and 35 years of age (
= 12). Pieces were divided randomly into two groups, control and treatment (with 1 μM kisspeptin). Real-time PCR was performed for
,
and
gene expression assessments. Western blotting was carried out to measure AKT and FOXO3a protein expression. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's test; means were considered significantly different at a
-value < 0.05. During treatment with the kisspeptin group, maturity genes are expressed. Therefore, kisspeptin is an effective substance to improve the quality of the human ovarian medium as it increases the maturity of follicles.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>38099429</pmid><doi>10.1017/S0967199423000527</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-2262-1302</orcidid><orcidid>https://orcid.org/0000-0003-1402-6482</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0967-1994 |
| ispartof | Zygote (Cambridge), 2024-02, Vol.32 (1), p.66-70 |
| issn | 0967-1994 1469-8730 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2902964450 |
| source | Cambridge University Press Journals Complete |
| subjects | AKT protein Antibodies Chemotherapy Eggs Follicles FOXO3 protein Gene expression Health services Infertility Kinases Kiss1 protein Medical science Ovaries Ovulation Penicillin Proteins Puberty Reproductive status Side effects Signal quality TOR protein Transplants & implants Variance analysis Western blotting |
| title | Effects of kisspeptin on the maturation of human ovarian primordial follicles in vitro |
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