Prevalence and interpretation of AFF immunostain of DEK::AFF2 fusion-associated papillary squamous cell carcinoma in a retrospective cohort of recurrent sinonasal papillomas
DEK:: AFF2 fusion-associated papillary squamous cell carcinoma is a novel entity characterized by its unique translocation and malignant clinical course. In this study, AFF immunohistochemistry (IHC) was performed in recurrent sinonasal papillomas for reviewing the prevalence of undiagnosed DEK::AFF...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2024, Vol.484 (1), p.119-125 |
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| creator | Ng, Joanna K. M. Chow, Chit Tang, Cheuk-yin Chan, Angela Z. Li, Joshua J. X. Chan, Amy B. W. |
| description | DEK::
AFF2
fusion-associated papillary squamous cell carcinoma is a novel entity characterized by its unique translocation and malignant clinical course. In this study, AFF immunohistochemistry (IHC) was performed in recurrent sinonasal papillomas for reviewing the prevalence of undiagnosed
DEK::AFF2
carcinomas and to investigate the performance of AFF IHC in diagnosis of
DEK::AFF2
carcinomas. Recurrent sinonasal papillomas after surgical excision in a two-decade period were retrieved. Histologic slides were reviewed for features of
DEK::AFF2
carcinoma. AFF IHC was performed, and cases with any (> 1%) nuclear positivity were validated by
DEK
break apart fluorescence in situ hybridization. Totally 43 cases were included, comprising 28 inverted, 6 exophytic, one oncocytic, and 8 non-specified sinonasal papillomas. Five (11.6%) cases exhibited positivity to AFF IHC. Three cases exhibited patchy weak to moderate staining intensity predominantly in a granular cytoplasmic pattern. Two cases exhibited strong and diffuse (> 90%) nuclear staining. Cases showing weak staining were negative for
DEK
rearrangement, while those with strong staining were positive. Both cases of
DEK::AFF2
carcinoma showed aggressive behavior with extensive local invasion and nodal metastasis. Background stromal plasma cells, when present, consistently showed strong and diffuse staining. AFF IHC was further performed in plasmacytoma samples as control and showed strong and diffuse immunoreactivity. A significant minority of recurrent sinonasal papillomas represent
DEK::AFF2
carcinomas. Granular, cytoplasmic, or incomplete AFF staining should be considered as negative. In view of the rarity of
DEK::AFF2
carcinomas, plasma cells and plasma cell neoplasms are potential for internal and surrogate external controls. |
| doi_str_mv | 10.1007/s00428-023-03717-0 |
| format | Article |
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AFF2
fusion-associated papillary squamous cell carcinoma is a novel entity characterized by its unique translocation and malignant clinical course. In this study, AFF immunohistochemistry (IHC) was performed in recurrent sinonasal papillomas for reviewing the prevalence of undiagnosed
DEK::AFF2
carcinomas and to investigate the performance of AFF IHC in diagnosis of
DEK::AFF2
carcinomas. Recurrent sinonasal papillomas after surgical excision in a two-decade period were retrieved. Histologic slides were reviewed for features of
DEK::AFF2
carcinoma. AFF IHC was performed, and cases with any (> 1%) nuclear positivity were validated by
DEK
break apart fluorescence in situ hybridization. Totally 43 cases were included, comprising 28 inverted, 6 exophytic, one oncocytic, and 8 non-specified sinonasal papillomas. Five (11.6%) cases exhibited positivity to AFF IHC. Three cases exhibited patchy weak to moderate staining intensity predominantly in a granular cytoplasmic pattern. Two cases exhibited strong and diffuse (> 90%) nuclear staining. Cases showing weak staining were negative for
DEK
rearrangement, while those with strong staining were positive. Both cases of
DEK::AFF2
carcinoma showed aggressive behavior with extensive local invasion and nodal metastasis. Background stromal plasma cells, when present, consistently showed strong and diffuse staining. AFF IHC was further performed in plasmacytoma samples as control and showed strong and diffuse immunoreactivity. A significant minority of recurrent sinonasal papillomas represent
DEK::AFF2
carcinomas. Granular, cytoplasmic, or incomplete AFF staining should be considered as negative. In view of the rarity of
DEK::AFF2
carcinomas, plasma cells and plasma cell neoplasms are potential for internal and surrogate external controls.</description><identifier>ISSN: 0945-6317</identifier><identifier>ISSN: 1432-2307</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-023-03717-0</identifier><identifier>PMID: 38063896</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer ; Carcinoma, Squamous Cell - pathology ; Cell fusion ; Fluorescence in situ hybridization ; Head and Neck Neoplasms ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Medicine ; Medicine & Public Health ; Metastases ; Neoplasms ; Nuclear Proteins ; Original Article ; Papilloma - pathology ; Paranasal sinus ; Pathology ; Plasma cells ; Plasmacytoma ; Prevalence ; Retrospective Studies ; Squamous cell carcinoma ; Staining ; Translocation</subject><ispartof>Virchows Archiv : an international journal of pathology, 2024, Vol.484 (1), p.119-125</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-8990fccefcc70f77f33400f069749f41dceee1a66f3adaa9337d7e16fbfd82663</cites><orcidid>0000-0003-2425-0314</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-023-03717-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-023-03717-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38063896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Joanna K. M.</creatorcontrib><creatorcontrib>Chow, Chit</creatorcontrib><creatorcontrib>Tang, Cheuk-yin</creatorcontrib><creatorcontrib>Chan, Angela Z.</creatorcontrib><creatorcontrib>Li, Joshua J. X.</creatorcontrib><creatorcontrib>Chan, Amy B. W.</creatorcontrib><title>Prevalence and interpretation of AFF immunostain of DEK::AFF2 fusion-associated papillary squamous cell carcinoma in a retrospective cohort of recurrent sinonasal papillomas</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>DEK::
AFF2
fusion-associated papillary squamous cell carcinoma is a novel entity characterized by its unique translocation and malignant clinical course. In this study, AFF immunohistochemistry (IHC) was performed in recurrent sinonasal papillomas for reviewing the prevalence of undiagnosed
DEK::AFF2
carcinomas and to investigate the performance of AFF IHC in diagnosis of
DEK::AFF2
carcinomas. Recurrent sinonasal papillomas after surgical excision in a two-decade period were retrieved. Histologic slides were reviewed for features of
DEK::AFF2
carcinoma. AFF IHC was performed, and cases with any (> 1%) nuclear positivity were validated by
DEK
break apart fluorescence in situ hybridization. Totally 43 cases were included, comprising 28 inverted, 6 exophytic, one oncocytic, and 8 non-specified sinonasal papillomas. Five (11.6%) cases exhibited positivity to AFF IHC. Three cases exhibited patchy weak to moderate staining intensity predominantly in a granular cytoplasmic pattern. Two cases exhibited strong and diffuse (> 90%) nuclear staining. Cases showing weak staining were negative for
DEK
rearrangement, while those with strong staining were positive. Both cases of
DEK::AFF2
carcinoma showed aggressive behavior with extensive local invasion and nodal metastasis. Background stromal plasma cells, when present, consistently showed strong and diffuse staining. AFF IHC was further performed in plasmacytoma samples as control and showed strong and diffuse immunoreactivity. A significant minority of recurrent sinonasal papillomas represent
DEK::AFF2
carcinomas. Granular, cytoplasmic, or incomplete AFF staining should be considered as negative. In view of the rarity of
DEK::AFF2
carcinomas, plasma cells and plasma cell neoplasms are potential for internal and surrogate external controls.</description><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell fusion</subject><subject>Fluorescence in situ hybridization</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Neoplasms</subject><subject>Nuclear Proteins</subject><subject>Original Article</subject><subject>Papilloma - pathology</subject><subject>Paranasal sinus</subject><subject>Pathology</subject><subject>Plasma cells</subject><subject>Plasmacytoma</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Squamous cell carcinoma</subject><subject>Staining</subject><subject>Translocation</subject><issn>0945-6317</issn><issn>1432-2307</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcFu1DAQhi0EosvCC3BAlrhwCYzt1E56q0oXEJXgAOdo6ozBVWKntlOJh-Id8XYXkDhwsC2Nv_nHv3_Gngt4LQDMmwzQyq4BqRpQRpgGHrCNaJVspALzkG2gb08brYQ5YU9yvgGQohP6MTtRHWjV9XrDfn5OdIcTBUscw8h9KJSWRAWLj4FHx893O-7neQ0xF_T3pbeXH8_Oal1yt-aKNZhztB4LjXzBxU8Tph883644xzVzS9PELSbrQ5yxjuDI64QU80K2-DviNn6PqeylE9k1JQqF50oHzDgdJWtrfsoeOZwyPTueW_Z1d_nl4n1z9endh4vzq8YqqUvT9T04a6kuA84Yp1QL4ED3pu1dK0ZLRAK1dgpHxF4pMxoS2l27sZNaqy17ddBdUrxdKZdh9nlvAwNVR4PsQfZa6dq5ZS__QW_imkJ9XaXEaat6KbtKyQNlq-ucyA1L8nP9pUHAsA9zOIQ51DCH-zDrvmUvjtLr9Uzjn5bf6VVAHYBcr8I3Sn9n_0f2F2nKrf0</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Ng, Joanna K. 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M.</au><au>Chow, Chit</au><au>Tang, Cheuk-yin</au><au>Chan, Angela Z.</au><au>Li, Joshua J. X.</au><au>Chan, Amy B. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and interpretation of AFF immunostain of DEK::AFF2 fusion-associated papillary squamous cell carcinoma in a retrospective cohort of recurrent sinonasal papillomas</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2024</date><risdate>2024</risdate><volume>484</volume><issue>1</issue><spage>119</spage><epage>125</epage><pages>119-125</pages><issn>0945-6317</issn><issn>1432-2307</issn><eissn>1432-2307</eissn><abstract>DEK::
AFF2
fusion-associated papillary squamous cell carcinoma is a novel entity characterized by its unique translocation and malignant clinical course. In this study, AFF immunohistochemistry (IHC) was performed in recurrent sinonasal papillomas for reviewing the prevalence of undiagnosed
DEK::AFF2
carcinomas and to investigate the performance of AFF IHC in diagnosis of
DEK::AFF2
carcinomas. Recurrent sinonasal papillomas after surgical excision in a two-decade period were retrieved. Histologic slides were reviewed for features of
DEK::AFF2
carcinoma. AFF IHC was performed, and cases with any (> 1%) nuclear positivity were validated by
DEK
break apart fluorescence in situ hybridization. Totally 43 cases were included, comprising 28 inverted, 6 exophytic, one oncocytic, and 8 non-specified sinonasal papillomas. Five (11.6%) cases exhibited positivity to AFF IHC. Three cases exhibited patchy weak to moderate staining intensity predominantly in a granular cytoplasmic pattern. Two cases exhibited strong and diffuse (> 90%) nuclear staining. Cases showing weak staining were negative for
DEK
rearrangement, while those with strong staining were positive. Both cases of
DEK::AFF2
carcinoma showed aggressive behavior with extensive local invasion and nodal metastasis. Background stromal plasma cells, when present, consistently showed strong and diffuse staining. AFF IHC was further performed in plasmacytoma samples as control and showed strong and diffuse immunoreactivity. A significant minority of recurrent sinonasal papillomas represent
DEK::AFF2
carcinomas. Granular, cytoplasmic, or incomplete AFF staining should be considered as negative. In view of the rarity of
DEK::AFF2
carcinomas, plasma cells and plasma cell neoplasms are potential for internal and surrogate external controls.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38063896</pmid><doi>10.1007/s00428-023-03717-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2425-0314</orcidid></addata></record> |
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| ispartof | Virchows Archiv : an international journal of pathology, 2024, Vol.484 (1), p.119-125 |
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| subjects | Cancer Carcinoma, Squamous Cell - pathology Cell fusion Fluorescence in situ hybridization Head and Neck Neoplasms Humans Immunohistochemistry In Situ Hybridization, Fluorescence Medicine Medicine & Public Health Metastases Neoplasms Nuclear Proteins Original Article Papilloma - pathology Paranasal sinus Pathology Plasma cells Plasmacytoma Prevalence Retrospective Studies Squamous cell carcinoma Staining Translocation |
| title | Prevalence and interpretation of AFF immunostain of DEK::AFF2 fusion-associated papillary squamous cell carcinoma in a retrospective cohort of recurrent sinonasal papillomas |
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