PML Body Biogenesis: A Delicate Balance of Interactions
PML bodies are subnuclear protein complexes that play a crucial role in various physiological and pathological cellular processes. One of the general structural proteins of PML bodies is a member of the tripartite motif (TRIM) family-promyelocytic leukemia protein (PML). It is known that PML interac...
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| Veröffentlicht in: | International journal of molecular sciences 2023-12, Vol.24 (23), p.16702 |
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| creator | Silonov, Sergey A Smirnov, Eugene Y Kuznetsova, Irina M Turoverov, Konstantin K Fonin, Alexander V |
| description | PML bodies are subnuclear protein complexes that play a crucial role in various physiological and pathological cellular processes. One of the general structural proteins of PML bodies is a member of the tripartite motif (TRIM) family-promyelocytic leukemia protein (PML). It is known that PML interacts with over a hundred partners, and the protein itself is represented by several major isoforms, differing in their variable and disordered C-terminal end due to alternative splicing. Despite nearly 30 years of research, the mechanisms underlying PML body formation and the role of PML proteins in this process remain largely unclear. In this review, we examine the literature and highlight recent progress in this field, with a particular focus on understanding the role of individual domains of the PML protein, its post-translational modifications, and polyvalent nonspecific interactions in the formation of PML bodies. Additionally, based on the available literature, we propose a new hypothetical model of PML body formation. |
| doi_str_mv | 10.3390/ijms242316702 |
| format | Article |
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One of the general structural proteins of PML bodies is a member of the tripartite motif (TRIM) family-promyelocytic leukemia protein (PML). It is known that PML interacts with over a hundred partners, and the protein itself is represented by several major isoforms, differing in their variable and disordered C-terminal end due to alternative splicing. Despite nearly 30 years of research, the mechanisms underlying PML body formation and the role of PML proteins in this process remain largely unclear. In this review, we examine the literature and highlight recent progress in this field, with a particular focus on understanding the role of individual domains of the PML protein, its post-translational modifications, and polyvalent nonspecific interactions in the formation of PML bodies. 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| subjects | Amino acids Apoptosis Biopolymers Breast cancer Cell cycle Chromosomes Leukemia Localization Nuclear Proteins - metabolism Physiological aspects Promyelocytic Leukemia Nuclear Bodies Promyelocytic Leukemia Protein - chemistry Promyelocytic Leukemia Protein - genetics Protein expression Proteins Transcription Factors - metabolism Tripartite Motif Proteins Tumor Suppressor Proteins - metabolism |
| title | PML Body Biogenesis: A Delicate Balance of Interactions |
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