Multi-Fusarium mycotoxin exposure activates Nrf2 and Ahr pathway in the liver of laying hens

This study investigates gene expression changes in laying hens exposed to trichothecene mycotoxins, known to induce oxidative stress and affect xenobiotic transformation and antioxidants. A 3-day feeding trial tested low and high doses of T-2/HT-2 toxin, DON/3-AcDON/15-AcDON, and FB1 in hen feed. Re...

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Veröffentlicht in:	Toxicology letters 2024-01, Vol.391, p.55-61
Hauptverfasser:	Kövesi, Benjamin, Kulcsár, Szabina, Ancsin, Zsolt, Erdélyi, Márta, Zándoki, Erika, Gömbös, Patrik, Balogh, Krisztián, Mézes, Miklós
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Aryl hydrocarbon receptor Chickens Cytochrome P-450 CYP1A2 - metabolism Deoxynivalenol Female Fumonisin B1 Fusarium - metabolism Glutathione redox system Kelch-Like ECH-Associated Protein 1 Laying hens Liver - metabolism Mycotoxins - toxicity NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative stress Reactive Oxygen Species - metabolism Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism T-2 Toxin - metabolism T-2 Toxin - toxicity T2 toxin
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