Multiple colorectal adenomas syndrome: The role of MUTYH mutation and the polyps’ number in clinical management and colorectal cancer risk

Multiple colorectal adenomas (MCRAs) can result from APC (AFAP) or biallelic MUTYH (MAP) mutations, but most patients are wild type and referred to as non-APC/MUTYH polyposis (NAMP). We aim to examine the risk of colorectal cancer (CRC) and the role of endoscopy in managing patients with MCRAs, with...

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Veröffentlicht in:	Digestive and liver disease 2024-06, Vol.56 (6), p.1087-1094
Hauptverfasser:	Negro, Silvia, Bao, Quoc Riccardo, Scarpa, Marco, Scognamiglio, Federico, Pucciarelli, Salvatore, Remo, Andrea, Agostini, Marco, D'Angelo, Edoardo, Mammi, Isabella, Schiavi, Francesca, Rossi, Silvia, Zingone, Fabiana, Ferrara, Francesco, Fantin, Alberto, Cristofori, Chiara, Guido, Ennio, Rizzotto, Erik Rosa, Intini, Rossana, Bergamo, Francesca, Fassan, Matteo, Salviati, Leonardo, Urso, Emanuele D.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Adenoma - surgery Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - surgery Adult Aged Colonic Polyps - genetics Colonic Polyps - pathology Colonic Polyps - surgery Colonoscopy Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal polyposis DNA Glycosylases - genetics Familial adenomatous polyposis Female Genotype Humans Male Middle Aged Mutation MUTYH associated polyposis Retrospective Studies
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