Synergistic cytotoxicity of decitabine and YM155 in leukemia cells through upregulation of SLC35F2 and suppression of MCL1 and survivin expression

The hypomethylation agent decitabine (DAC), in combination with other apoptosis inducers, is considered a potential modality for cancer treatment. We investigated the mechanism underlying the combined cytotoxicity of DAC and YM155 in acute myeloid leukemia (AML) cells because of increasing evidence...

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Veröffentlicht in:	Apoptosis (London) 2024-04, Vol.29 (3-4), p.503-520
Hauptverfasser:	Chiou, Jing-Ting, Chang, Long-Sen
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine Acute myeloid leukemia AKT protein Apoptosis Autophagy Biochemistry Biomedical and Life Sciences Biomedicine Calcium ions Cancer Cancer Research Cancer therapies Care and treatment Cell Biology Cell death Cyclic AMP response element-binding protein Cytotoxicity Degradation Depolarization Gene expression Leukemia MAP kinase Mcl-1 protein mRNA Oncology Phosphorylation RNA Survival Survivin Toxicity Translocation Up-regulation Virology
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