Cathodal HD-tDCS and attention: A study on patients with intractable left lateral frontal lobe epilepsy
Defects in the attentional network in patients with epilepsy are influenced by factors such as the location of epileptic foci. Examining the impact of cathodal high-definition transcranial direct current stimulation (HD-tDCS) on attention components could provide insights into potential attention-re...
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| Veröffentlicht in: | Epilepsy research 2024-01, Vol.199, p.107265-107265, Article 107265 |
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| creator | Roshan, Javad Hasan Nia Chamanabad, Ali Ghanaei Mashhadi, Ali Motamedi, Mahmoud |
| description | Defects in the attentional network in patients with epilepsy are influenced by factors such as the location of epileptic foci. Examining the impact of cathodal high-definition transcranial direct current stimulation (HD-tDCS) on attention components could provide insights into potential attention-related side effects of tDCS. This study aimed to investigate the effect of cathodal HD-tDCS on interictal epileptiform discharges (IEDs), auditory/visual (A/V) attention components, and reaction time (RT) in patients with intractable focal left lateral frontal lobe epilepsy (LFLE).
To control for variations in individual epilepsy syndrome, 12 adult participants diagnosed with drug-resistant left LFLE with focal cortical IEDs on C3 underwent repeated measurements at pretest, posttest, and follow-up steps. 4 × 1 ring electrodes (cathode on C3 and four anodes on F3, P3, T3, and Cz) delivered 2 mA DC for 20 min per session for 10 consecutive days. The integrated visual and auditory continuous performance test (IVA+) assessed the A/V attention components and RT. One-way repeated-measure ANOVA was used.
The findings suggest a significant effect in reducing IEDs. The IVA+ results showed a significant improvement in auditory divided attention and visual selective and focused attention (p |
| doi_str_mv | 10.1016/j.eplepsyres.2023.107265 |
| format | Article |
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To control for variations in individual epilepsy syndrome, 12 adult participants diagnosed with drug-resistant left LFLE with focal cortical IEDs on C3 underwent repeated measurements at pretest, posttest, and follow-up steps. 4 × 1 ring electrodes (cathode on C3 and four anodes on F3, P3, T3, and Cz) delivered 2 mA DC for 20 min per session for 10 consecutive days. The integrated visual and auditory continuous performance test (IVA+) assessed the A/V attention components and RT. One-way repeated-measure ANOVA was used.
The findings suggest a significant effect in reducing IEDs. The IVA+ results showed a significant improvement in auditory divided attention and visual selective and focused attention (p < 0.05). In the follow-up, these changes demonstrated lasting efficacy. A/V speed scales increased (p < 0.05), showing a significant decrease in reaction time.
Cathodal HD-tDCS significantly reduced IEDs and improved the components of auditory divided attention, visual focused attention, and visual selective attention, with a reduction in patient reaction time. A significant lasting, side-effect-free positive effect was observed for up to one month after the intervention.</description><identifier>ISSN: 0920-1211</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/j.eplepsyres.2023.107265</identifier><identifier>PMID: 38071911</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Adult ; Attention - physiology ; Drug Resistant Epilepsy - therapy ; Electrodes ; Epilepsies, Partial ; Epilepsy, Frontal Lobe - therapy ; Frontal Lobe ; Humans ; Transcranial Direct Current Stimulation - methods</subject><ispartof>Epilepsy research, 2024-01, Vol.199, p.107265-107265, Article 107265</ispartof><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c260t-2215808fc75dc1cbb9bd18764787c20a950c3f2bed1c5e6b368053f11f9fa6cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38071911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roshan, Javad Hasan Nia</creatorcontrib><creatorcontrib>Chamanabad, Ali Ghanaei</creatorcontrib><creatorcontrib>Mashhadi, Ali</creatorcontrib><creatorcontrib>Motamedi, Mahmoud</creatorcontrib><title>Cathodal HD-tDCS and attention: A study on patients with intractable left lateral frontal lobe epilepsy</title><title>Epilepsy research</title><addtitle>Epilepsy Res</addtitle><description>Defects in the attentional network in patients with epilepsy are influenced by factors such as the location of epileptic foci. Examining the impact of cathodal high-definition transcranial direct current stimulation (HD-tDCS) on attention components could provide insights into potential attention-related side effects of tDCS. This study aimed to investigate the effect of cathodal HD-tDCS on interictal epileptiform discharges (IEDs), auditory/visual (A/V) attention components, and reaction time (RT) in patients with intractable focal left lateral frontal lobe epilepsy (LFLE).
To control for variations in individual epilepsy syndrome, 12 adult participants diagnosed with drug-resistant left LFLE with focal cortical IEDs on C3 underwent repeated measurements at pretest, posttest, and follow-up steps. 4 × 1 ring electrodes (cathode on C3 and four anodes on F3, P3, T3, and Cz) delivered 2 mA DC for 20 min per session for 10 consecutive days. The integrated visual and auditory continuous performance test (IVA+) assessed the A/V attention components and RT. One-way repeated-measure ANOVA was used.
The findings suggest a significant effect in reducing IEDs. The IVA+ results showed a significant improvement in auditory divided attention and visual selective and focused attention (p < 0.05). In the follow-up, these changes demonstrated lasting efficacy. A/V speed scales increased (p < 0.05), showing a significant decrease in reaction time.
Cathodal HD-tDCS significantly reduced IEDs and improved the components of auditory divided attention, visual focused attention, and visual selective attention, with a reduction in patient reaction time. A significant lasting, side-effect-free positive effect was observed for up to one month after the intervention.</description><subject>Adult</subject><subject>Attention - physiology</subject><subject>Drug Resistant Epilepsy - therapy</subject><subject>Electrodes</subject><subject>Epilepsies, Partial</subject><subject>Epilepsy, Frontal Lobe - therapy</subject><subject>Frontal Lobe</subject><subject>Humans</subject><subject>Transcranial Direct Current Stimulation - methods</subject><issn>0920-1211</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAQhC0EoqXwF5CPXFLWzsvhVqVAkSpxAM6W46xpKjcJtiPUf09KeZxGGs3O7n6EUAZzBiy73c6xt9j7vUM_58Dj0c55lp6QKRM5jzKRJKdkCgWHiHHGJuTC-y0A5JAk52QSC8hZwdiUvJcqbLpaWbpaRmFZvlDV1lSFgG1ouvaOLqgPQ72nXUt7FZrR9vSzCRvatMEpHVRlkVo0gVoV0I1FxnVtGNV2FVLsm-9DL8mZUdbj1Y_OyNvD_Wu5itbPj0_lYh1pnkGIOGepAGF0ntaa6aoqqnr8KEtykWsOqkhBx4ZXWDOdYlbFmYA0NoyZwqhMm3hGbo69ves-BvRB7hqv0VrVYjd4yQvgRSoKSMaoOEa167x3aGTvmp1ye8lAHjDLrfzHLA-Y5RHzOHr9s2Wodlj_Df5yjb8A4dd9hw</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Roshan, Javad Hasan Nia</creator><creator>Chamanabad, Ali Ghanaei</creator><creator>Mashhadi, Ali</creator><creator>Motamedi, Mahmoud</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202401</creationdate><title>Cathodal HD-tDCS and attention: A study on patients with intractable left lateral frontal lobe epilepsy</title><author>Roshan, Javad Hasan Nia ; Chamanabad, Ali Ghanaei ; Mashhadi, Ali ; Motamedi, Mahmoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c260t-2215808fc75dc1cbb9bd18764787c20a950c3f2bed1c5e6b368053f11f9fa6cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Attention - physiology</topic><topic>Drug Resistant Epilepsy - therapy</topic><topic>Electrodes</topic><topic>Epilepsies, Partial</topic><topic>Epilepsy, Frontal Lobe - therapy</topic><topic>Frontal Lobe</topic><topic>Humans</topic><topic>Transcranial Direct Current Stimulation - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roshan, Javad Hasan Nia</creatorcontrib><creatorcontrib>Chamanabad, Ali Ghanaei</creatorcontrib><creatorcontrib>Mashhadi, Ali</creatorcontrib><creatorcontrib>Motamedi, Mahmoud</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roshan, Javad Hasan Nia</au><au>Chamanabad, Ali Ghanaei</au><au>Mashhadi, Ali</au><au>Motamedi, Mahmoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cathodal HD-tDCS and attention: A study on patients with intractable left lateral frontal lobe epilepsy</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>2024-01</date><risdate>2024</risdate><volume>199</volume><spage>107265</spage><epage>107265</epage><pages>107265-107265</pages><artnum>107265</artnum><issn>0920-1211</issn><eissn>1872-6844</eissn><abstract>Defects in the attentional network in patients with epilepsy are influenced by factors such as the location of epileptic foci. Examining the impact of cathodal high-definition transcranial direct current stimulation (HD-tDCS) on attention components could provide insights into potential attention-related side effects of tDCS. This study aimed to investigate the effect of cathodal HD-tDCS on interictal epileptiform discharges (IEDs), auditory/visual (A/V) attention components, and reaction time (RT) in patients with intractable focal left lateral frontal lobe epilepsy (LFLE).
To control for variations in individual epilepsy syndrome, 12 adult participants diagnosed with drug-resistant left LFLE with focal cortical IEDs on C3 underwent repeated measurements at pretest, posttest, and follow-up steps. 4 × 1 ring electrodes (cathode on C3 and four anodes on F3, P3, T3, and Cz) delivered 2 mA DC for 20 min per session for 10 consecutive days. The integrated visual and auditory continuous performance test (IVA+) assessed the A/V attention components and RT. One-way repeated-measure ANOVA was used.
The findings suggest a significant effect in reducing IEDs. The IVA+ results showed a significant improvement in auditory divided attention and visual selective and focused attention (p < 0.05). In the follow-up, these changes demonstrated lasting efficacy. A/V speed scales increased (p < 0.05), showing a significant decrease in reaction time.
Cathodal HD-tDCS significantly reduced IEDs and improved the components of auditory divided attention, visual focused attention, and visual selective attention, with a reduction in patient reaction time. A significant lasting, side-effect-free positive effect was observed for up to one month after the intervention.</abstract><cop>Netherlands</cop><pmid>38071911</pmid><doi>10.1016/j.eplepsyres.2023.107265</doi><tpages>1</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Attention - physiology Drug Resistant Epilepsy - therapy Electrodes Epilepsies, Partial Epilepsy, Frontal Lobe - therapy Frontal Lobe Humans Transcranial Direct Current Stimulation - methods |
| title | Cathodal HD-tDCS and attention: A study on patients with intractable left lateral frontal lobe epilepsy |
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