Treatment evaluation of Rheumatoid arthritis by in situ fluorescence imaging of the Golgi cysteine

Rheumatoid arthritis (RA) is a long-term systemic inflammatory disease that causes severe joint pain. Golgi stress caused by redox imbalance significantly involves in acute and chronic inflammatory diseases, in which cysteine (Cys), as a representative reducing agent, may be an effective biomarker f...

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Veröffentlicht in:Talanta (Oxford) 2024-04, Vol.270, p.125532-125532, Article 125532
Hauptverfasser: Wang, Hui, Wen, Na, Li, Ping, Xiu, Tiancong, Shang, Shuqi, Zhang, Wei, Zhang, Wen, Qiao, Junnan, Tang, Bo
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container_title Talanta (Oxford)
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creator Wang, Hui
Wen, Na
Li, Ping
Xiu, Tiancong
Shang, Shuqi
Zhang, Wei
Zhang, Wen
Qiao, Junnan
Tang, Bo
description Rheumatoid arthritis (RA) is a long-term systemic inflammatory disease that causes severe joint pain. Golgi stress caused by redox imbalance significantly involves in acute and chronic inflammatory diseases, in which cysteine (Cys), as a representative reducing agent, may be an effective biomarker for RA. Hence, in order to achieve RA early detection and drugs evaluation, based on our previous work about innovative Golgi-targeting group, we established a phenylsulfonamide-modified fluorescence probe, Golgi-Cys, for the selective fluorescence imaging of Cys in Golgi apparatus in vivo. By application of Golgi-Cys, the Cys changes under Golgi stress in cells were elucidated. More importantly, we found that the probe can be effectively utilized for the RA detection and treatment evaluation in situ.
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Golgi stress caused by redox imbalance significantly involves in acute and chronic inflammatory diseases, in which cysteine (Cys), as a representative reducing agent, may be an effective biomarker for RA. Hence, in order to achieve RA early detection and drugs evaluation, based on our previous work about innovative Golgi-targeting group, we established a phenylsulfonamide-modified fluorescence probe, Golgi-Cys, for the selective fluorescence imaging of Cys in Golgi apparatus in vivo. By application of Golgi-Cys, the Cys changes under Golgi stress in cells were elucidated. 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title Treatment evaluation of Rheumatoid arthritis by in situ fluorescence imaging of the Golgi cysteine
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