Predictors of Interstitial Lung Disease in Mixed Connective Tissue Disease
Interstitial lung disease (ILD) frequently complicates mixed connective tissue disease (MCTD) and contributes to increased mortality. We aimed to identify predictors of ILD in MCTD patients. This is a nationwide, multicentre, retrospective study including patients with an adult-onset MCTD clinical d...
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| Veröffentlicht in: | Journal of clinical medicine 2023-12, Vol.12 (23), p.7481 |
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| creator | Silvério-António, Manuel Martins-Martinho, Joana Melo, Ana Teresa Guimarães, Francisca Dourado, Eduardo Oliveira, Daniela Lopes, Jorge Saraiva, André Gago, Ana Correia, Margarida Fernandes, Ana L Dinis, Sara Teixeira, Rafaela Silva, Susana P Costa, Carlos Beirão, Tiago Furtado, Carolina Abreu, Pedro Afonso, Carmo Khmelinskii, Nikita |
| description | Interstitial lung disease (ILD) frequently complicates mixed connective tissue disease (MCTD) and contributes to increased mortality. We aimed to identify predictors of ILD in MCTD patients. This is a nationwide, multicentre, retrospective study including patients with an adult-onset MCTD clinical diagnosis who met Sharp's, Kasukawa, Alarcón-Segovia, or Kahn's diagnostic criteria and had available chest high-resolution computed tomography (HRCT) data. Univariate and multivariate analyses were conducted. We included 57 MCTD patients, with 27 (47.4%) having ILD. Among ILD patients, 48.1% were asymptomatic, 80.0% exhibited a restrictive pattern on pulmonary function tests, and 81.5% had nonspecific interstitial pneumonia on chest HRCT. Gastroesophageal involvement (40.7% vs. 16.7%,
= 0.043) and lymphadenopathy at disease onset (22.2% vs. 3.3%,
= 0.045) were associated with ILD. Binary logistic regression identified lymphadenopathy at disease onset (OR 19.65, 95% CI: 1.91-201.75,
= 0.012) and older age at diagnosis (OR 1.06/year, 95% CI: 1.00-1.12,
= 0.046) as independent ILD predictors, regardless of gender and gastroesophageal involvement. This study is the first to assess a Portuguese MCTD cohort. As previously reported, it confirmed the link between gastroesophageal involvement and ILD in MCTD patients. Additionally, it established that lymphadenopathy at disease onset and older age at diagnosis independently predict ILD in MCTD patients. |
| doi_str_mv | 10.3390/jcm12237481 |
| format | Article |
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= 0.043) and lymphadenopathy at disease onset (22.2% vs. 3.3%,
= 0.045) were associated with ILD. Binary logistic regression identified lymphadenopathy at disease onset (OR 19.65, 95% CI: 1.91-201.75,
= 0.012) and older age at diagnosis (OR 1.06/year, 95% CI: 1.00-1.12,
= 0.046) as independent ILD predictors, regardless of gender and gastroesophageal involvement. This study is the first to assess a Portuguese MCTD cohort. As previously reported, it confirmed the link between gastroesophageal involvement and ILD in MCTD patients. Additionally, it established that lymphadenopathy at disease onset and older age at diagnosis independently predict ILD in MCTD patients.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12237481</identifier><identifier>PMID: 38068534</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Arthritis ; Asymptomatic ; Clinical medicine ; Complications and side effects ; Confidentiality ; Connective tissue diseases ; Data collection ; Demographic aspects ; Development and progression ; Diagnosis ; Dysphagia ; General Data Protection Regulation ; Health aspects ; Kinases ; Lung diseases ; Lung diseases, Interstitial ; Medical research ; Medicine, Experimental ; Mortality ; Multivariate analysis ; Patients ; Pneumonia ; Portugal ; Pulmonary function tests ; Regression analysis ; Risk factors ; Statistical analysis ; Variables ; White people</subject><ispartof>Journal of clinical medicine, 2023-12, Vol.12 (23), p.7481</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c379t-eab993018556290ae2f7809bd8d316928893e6b965c6a004cd92a3fd1d78259e3</cites><orcidid>0000-0001-6358-7388 ; 0000-0002-0975-2693 ; 0000-0003-2186-2833 ; 0000-0003-1347-6721 ; 0000-0001-6410-0121 ; 0000-0003-4983-0833 ; 0000-0001-9734-3162</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38068534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silvério-António, Manuel</creatorcontrib><creatorcontrib>Martins-Martinho, Joana</creatorcontrib><creatorcontrib>Melo, Ana Teresa</creatorcontrib><creatorcontrib>Guimarães, Francisca</creatorcontrib><creatorcontrib>Dourado, Eduardo</creatorcontrib><creatorcontrib>Oliveira, Daniela</creatorcontrib><creatorcontrib>Lopes, Jorge</creatorcontrib><creatorcontrib>Saraiva, André</creatorcontrib><creatorcontrib>Gago, Ana</creatorcontrib><creatorcontrib>Correia, Margarida</creatorcontrib><creatorcontrib>Fernandes, Ana L</creatorcontrib><creatorcontrib>Dinis, Sara</creatorcontrib><creatorcontrib>Teixeira, Rafaela</creatorcontrib><creatorcontrib>Silva, Susana P</creatorcontrib><creatorcontrib>Costa, Carlos</creatorcontrib><creatorcontrib>Beirão, Tiago</creatorcontrib><creatorcontrib>Furtado, Carolina</creatorcontrib><creatorcontrib>Abreu, Pedro</creatorcontrib><creatorcontrib>Afonso, Carmo</creatorcontrib><creatorcontrib>Khmelinskii, Nikita</creatorcontrib><title>Predictors of Interstitial Lung Disease in Mixed Connective Tissue Disease</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Interstitial lung disease (ILD) frequently complicates mixed connective tissue disease (MCTD) and contributes to increased mortality. We aimed to identify predictors of ILD in MCTD patients. This is a nationwide, multicentre, retrospective study including patients with an adult-onset MCTD clinical diagnosis who met Sharp's, Kasukawa, Alarcón-Segovia, or Kahn's diagnostic criteria and had available chest high-resolution computed tomography (HRCT) data. Univariate and multivariate analyses were conducted. We included 57 MCTD patients, with 27 (47.4%) having ILD. Among ILD patients, 48.1% were asymptomatic, 80.0% exhibited a restrictive pattern on pulmonary function tests, and 81.5% had nonspecific interstitial pneumonia on chest HRCT. Gastroesophageal involvement (40.7% vs. 16.7%,
= 0.043) and lymphadenopathy at disease onset (22.2% vs. 3.3%,
= 0.045) were associated with ILD. Binary logistic regression identified lymphadenopathy at disease onset (OR 19.65, 95% CI: 1.91-201.75,
= 0.012) and older age at diagnosis (OR 1.06/year, 95% CI: 1.00-1.12,
= 0.046) as independent ILD predictors, regardless of gender and gastroesophageal involvement. This study is the first to assess a Portuguese MCTD cohort. As previously reported, it confirmed the link between gastroesophageal involvement and ILD in MCTD patients. Additionally, it established that lymphadenopathy at disease onset and older age at diagnosis independently predict ILD in MCTD patients.</description><subject>Arthritis</subject><subject>Asymptomatic</subject><subject>Clinical medicine</subject><subject>Complications and side effects</subject><subject>Confidentiality</subject><subject>Connective tissue diseases</subject><subject>Data collection</subject><subject>Demographic aspects</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Dysphagia</subject><subject>General Data Protection Regulation</subject><subject>Health aspects</subject><subject>Kinases</subject><subject>Lung diseases</subject><subject>Lung diseases, Interstitial</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Portugal</subject><subject>Pulmonary function 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Med</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>12</volume><issue>23</issue><spage>7481</spage><pages>7481-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Interstitial lung disease (ILD) frequently complicates mixed connective tissue disease (MCTD) and contributes to increased mortality. We aimed to identify predictors of ILD in MCTD patients. This is a nationwide, multicentre, retrospective study including patients with an adult-onset MCTD clinical diagnosis who met Sharp's, Kasukawa, Alarcón-Segovia, or Kahn's diagnostic criteria and had available chest high-resolution computed tomography (HRCT) data. Univariate and multivariate analyses were conducted. We included 57 MCTD patients, with 27 (47.4%) having ILD. Among ILD patients, 48.1% were asymptomatic, 80.0% exhibited a restrictive pattern on pulmonary function tests, and 81.5% had nonspecific interstitial pneumonia on chest HRCT. Gastroesophageal involvement (40.7% vs. 16.7%,
= 0.043) and lymphadenopathy at disease onset (22.2% vs. 3.3%,
= 0.045) were associated with ILD. Binary logistic regression identified lymphadenopathy at disease onset (OR 19.65, 95% CI: 1.91-201.75,
= 0.012) and older age at diagnosis (OR 1.06/year, 95% CI: 1.00-1.12,
= 0.046) as independent ILD predictors, regardless of gender and gastroesophageal involvement. This study is the first to assess a Portuguese MCTD cohort. As previously reported, it confirmed the link between gastroesophageal involvement and ILD in MCTD patients. Additionally, it established that lymphadenopathy at disease onset and older age at diagnosis independently predict ILD in MCTD patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38068534</pmid><doi>10.3390/jcm12237481</doi><orcidid>https://orcid.org/0000-0001-6358-7388</orcidid><orcidid>https://orcid.org/0000-0002-0975-2693</orcidid><orcidid>https://orcid.org/0000-0003-2186-2833</orcidid><orcidid>https://orcid.org/0000-0003-1347-6721</orcidid><orcidid>https://orcid.org/0000-0001-6410-0121</orcidid><orcidid>https://orcid.org/0000-0003-4983-0833</orcidid><orcidid>https://orcid.org/0000-0001-9734-3162</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arthritis Asymptomatic Clinical medicine Complications and side effects Confidentiality Connective tissue diseases Data collection Demographic aspects Development and progression Diagnosis Dysphagia General Data Protection Regulation Health aspects Kinases Lung diseases Lung diseases, Interstitial Medical research Medicine, Experimental Mortality Multivariate analysis Patients Pneumonia Portugal Pulmonary function tests Regression analysis Risk factors Statistical analysis Variables White people |
| title | Predictors of Interstitial Lung Disease in Mixed Connective Tissue Disease |
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