Twenty-four-hour urinary protein excretion in uncomplicated singleton pregnancy
Twenty-four-hour urinary total protein excretion is an essential parameter used for evaluation of renal function and early detection of gestational complications. However, data on reference ranges of 24-hour urinary total protein excretion in normal pregnancy are scarce. This study aimed to determin...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2024-08, Vol.231 (2), p.257.e1-257.e12 |
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| creator | Deng, Yuguo Wu, Qiulu Tan, Xiaoyu Ye, Wei Liao, Guilian Yang, Jinying |
| description | Twenty-four-hour urinary total protein excretion is an essential parameter used for evaluation of renal function and early detection of gestational complications. However, data on reference ranges of 24-hour urinary total protein excretion in normal pregnancy are scarce.
This study aimed to determine reference ranges for 24-hour urinary total protein excretion in a population with uncomplicated singleton pregnancies using a standard method for urinary total protein. In addition, the values of 24-hour urinary total protein were stratified by maternal age and prepregnancy body mass index.
This study was based on a prospective cohort study in Shenzhen, China. The pregnant women were enrolled at their first prenatal clinical visit. All the participants were instructed to collect 24-hour urine samples during the following successive gestational periods: 6+0 to 13+6, 14+0 to 27+6, and 28+0 to 41+6 weeks. Total urinary protein excretion was analyzed by a colorimetric method. Ultimately, the study encompassed a total of 4844 pregnant women with uncomplicated pregnancies. The nonparametric percentile method was used to determine reference ranges for 24-hour urinary total protein excretion during different trimesters in women with uncomplicated pregnancies (excluding those with previous kidney disorders, gestational or chronic hypertension, preeclampsia, and pregestational diabetes mellitus, among others).
The 24-hour urinary total protein levels expressed as medians and percentiles (5th, 95th) for each trimester were as follows: 72.0 (28.4, 165.0), 88.0 (34.0, 185.0), and 108.0 (37.5, 258.0) mg in the first, second, and third trimesters, respectively. A significant increase in 24-hour urinary total protein excretion was observed throughout pregnancy (all P values |
| doi_str_mv | 10.1016/j.ajog.2023.12.009 |
| format | Article |
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This study aimed to determine reference ranges for 24-hour urinary total protein excretion in a population with uncomplicated singleton pregnancies using a standard method for urinary total protein. In addition, the values of 24-hour urinary total protein were stratified by maternal age and prepregnancy body mass index.
This study was based on a prospective cohort study in Shenzhen, China. The pregnant women were enrolled at their first prenatal clinical visit. All the participants were instructed to collect 24-hour urine samples during the following successive gestational periods: 6+0 to 13+6, 14+0 to 27+6, and 28+0 to 41+6 weeks. Total urinary protein excretion was analyzed by a colorimetric method. Ultimately, the study encompassed a total of 4844 pregnant women with uncomplicated pregnancies. The nonparametric percentile method was used to determine reference ranges for 24-hour urinary total protein excretion during different trimesters in women with uncomplicated pregnancies (excluding those with previous kidney disorders, gestational or chronic hypertension, preeclampsia, and pregestational diabetes mellitus, among others).
The 24-hour urinary total protein levels expressed as medians and percentiles (5th, 95th) for each trimester were as follows: 72.0 (28.4, 165.0), 88.0 (34.0, 185.0), and 108.0 (37.5, 258.0) mg in the first, second, and third trimesters, respectively. A significant increase in 24-hour urinary total protein excretion was observed throughout pregnancy (all P values <.001). Moreover, 24-hour urinary total protein levels were higher in the older (≥35 years) than in the younger (<35 years) group from mid-gestation. Specifically, the median (interquartile range) 24-hour urinary total protein levels by age were 72.2 (50.6–100.0) vs 70.5 (50.5–100.0) mg, 85.8 (62.0–117.0) vs 96.0 (68.0–127.8) mg, and 106.6 (76.0–146.2) vs 114.7 (81.5–153.6) mg in the first, second, and third trimesters, respectively. In addition, 24-hour proteinuria was significantly increased in higher-weight (overweight or obese) subgroups compared with lower-weight (underweight or normal-weight) subgroups (all P values <.05).
Our study provides reference values for 24-hour urinary total protein excretion with apparently uncomplicated pregnancies. Understanding these changes in low-risk pregnancies is essential for optimizing maternal management.
[Display omitted]</description><identifier>ISSN: 0002-9378</identifier><identifier>ISSN: 1097-6868</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2023.12.009</identifier><identifier>PMID: 38101528</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>24-hour urinary total protein excretion ; Adult ; Body Mass Index ; China ; Cohort Studies ; Female ; Humans ; Maternal Age ; Pregnancy ; Pregnancy Trimesters - urine ; Prospective Studies ; Proteinuria - urine ; reference ranges ; Reference Values ; uncomplicated pregnant women ; Young Adult</subject><ispartof>American journal of obstetrics and gynecology, 2024-08, Vol.231 (2), p.257.e1-257.e12</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-14180f9038699bb410c040b98d793dd98ff8121dceec7ca4b2660c5a80fad5c33</citedby><cites>FETCH-LOGICAL-c356t-14180f9038699bb410c040b98d793dd98ff8121dceec7ca4b2660c5a80fad5c33</cites><orcidid>0000-0003-1761-8678</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2023.12.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38101528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Yuguo</creatorcontrib><creatorcontrib>Wu, Qiulu</creatorcontrib><creatorcontrib>Tan, Xiaoyu</creatorcontrib><creatorcontrib>Ye, Wei</creatorcontrib><creatorcontrib>Liao, Guilian</creatorcontrib><creatorcontrib>Yang, Jinying</creatorcontrib><title>Twenty-four-hour urinary protein excretion in uncomplicated singleton pregnancy</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Twenty-four-hour urinary total protein excretion is an essential parameter used for evaluation of renal function and early detection of gestational complications. However, data on reference ranges of 24-hour urinary total protein excretion in normal pregnancy are scarce.
This study aimed to determine reference ranges for 24-hour urinary total protein excretion in a population with uncomplicated singleton pregnancies using a standard method for urinary total protein. In addition, the values of 24-hour urinary total protein were stratified by maternal age and prepregnancy body mass index.
This study was based on a prospective cohort study in Shenzhen, China. The pregnant women were enrolled at their first prenatal clinical visit. All the participants were instructed to collect 24-hour urine samples during the following successive gestational periods: 6+0 to 13+6, 14+0 to 27+6, and 28+0 to 41+6 weeks. Total urinary protein excretion was analyzed by a colorimetric method. Ultimately, the study encompassed a total of 4844 pregnant women with uncomplicated pregnancies. The nonparametric percentile method was used to determine reference ranges for 24-hour urinary total protein excretion during different trimesters in women with uncomplicated pregnancies (excluding those with previous kidney disorders, gestational or chronic hypertension, preeclampsia, and pregestational diabetes mellitus, among others).
The 24-hour urinary total protein levels expressed as medians and percentiles (5th, 95th) for each trimester were as follows: 72.0 (28.4, 165.0), 88.0 (34.0, 185.0), and 108.0 (37.5, 258.0) mg in the first, second, and third trimesters, respectively. A significant increase in 24-hour urinary total protein excretion was observed throughout pregnancy (all P values <.001). Moreover, 24-hour urinary total protein levels were higher in the older (≥35 years) than in the younger (<35 years) group from mid-gestation. Specifically, the median (interquartile range) 24-hour urinary total protein levels by age were 72.2 (50.6–100.0) vs 70.5 (50.5–100.0) mg, 85.8 (62.0–117.0) vs 96.0 (68.0–127.8) mg, and 106.6 (76.0–146.2) vs 114.7 (81.5–153.6) mg in the first, second, and third trimesters, respectively. In addition, 24-hour proteinuria was significantly increased in higher-weight (overweight or obese) subgroups compared with lower-weight (underweight or normal-weight) subgroups (all P values <.05).
Our study provides reference values for 24-hour urinary total protein excretion with apparently uncomplicated pregnancies. Understanding these changes in low-risk pregnancies is essential for optimizing maternal management.
[Display omitted]</description><subject>24-hour urinary total protein excretion</subject><subject>Adult</subject><subject>Body Mass Index</subject><subject>China</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Maternal Age</subject><subject>Pregnancy</subject><subject>Pregnancy Trimesters - urine</subject><subject>Prospective Studies</subject><subject>Proteinuria - urine</subject><subject>reference ranges</subject><subject>Reference Values</subject><subject>uncomplicated pregnant women</subject><subject>Young Adult</subject><issn>0002-9378</issn><issn>1097-6868</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PwzAMxSMEYmPwBTigHrm0OGnXJRIXNPFPmrTLOEdp4o5MXTqSFti3J9UGRy62LL_3ZP8IuaaQUaDl3SZTm3adMWB5RlkGIE7ImIKYpSUv-SkZAwBLRT7jI3IRwmYYmWDnZJTzGDBlfEyWqy903T6t296n77EkvbdO-X2y822H1iX4rT12tnVJHHqn2-2usVp1aJJg3brBLq52HtdOOb2_JGe1agJeHfuEvD09ruYv6WL5_Dp_WKQ6n5ZdSgvKoRaQ81KIqiooaCigEtzMRG6M4HXNKaNGI-qZVkXFyhL0VEWTMlOd5xNye8iNZ370GDq5tUFj0yiHbR8kE8BEEQuPUnaQat-G4LGWO2-38UVJQQ4g5UYOIOUAUlImI8houjnm99UWzZ_ll1wU3B8EGL_8tOhl0BadRmM96k6a1v6X_wOAFYWK</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Deng, Yuguo</creator><creator>Wu, Qiulu</creator><creator>Tan, Xiaoyu</creator><creator>Ye, Wei</creator><creator>Liao, Guilian</creator><creator>Yang, Jinying</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1761-8678</orcidid></search><sort><creationdate>20240801</creationdate><title>Twenty-four-hour urinary protein excretion in uncomplicated singleton pregnancy</title><author>Deng, Yuguo ; Wu, Qiulu ; Tan, Xiaoyu ; Ye, Wei ; Liao, Guilian ; Yang, Jinying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-14180f9038699bb410c040b98d793dd98ff8121dceec7ca4b2660c5a80fad5c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>24-hour urinary total protein excretion</topic><topic>Adult</topic><topic>Body Mass Index</topic><topic>China</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Maternal Age</topic><topic>Pregnancy</topic><topic>Pregnancy Trimesters - urine</topic><topic>Prospective Studies</topic><topic>Proteinuria - urine</topic><topic>reference ranges</topic><topic>Reference Values</topic><topic>uncomplicated pregnant women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Yuguo</creatorcontrib><creatorcontrib>Wu, Qiulu</creatorcontrib><creatorcontrib>Tan, Xiaoyu</creatorcontrib><creatorcontrib>Ye, Wei</creatorcontrib><creatorcontrib>Liao, Guilian</creatorcontrib><creatorcontrib>Yang, Jinying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Yuguo</au><au>Wu, Qiulu</au><au>Tan, Xiaoyu</au><au>Ye, Wei</au><au>Liao, Guilian</au><au>Yang, Jinying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Twenty-four-hour urinary protein excretion in uncomplicated singleton pregnancy</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>231</volume><issue>2</issue><spage>257.e1</spage><epage>257.e12</epage><pages>257.e1-257.e12</pages><issn>0002-9378</issn><issn>1097-6868</issn><eissn>1097-6868</eissn><abstract>Twenty-four-hour urinary total protein excretion is an essential parameter used for evaluation of renal function and early detection of gestational complications. However, data on reference ranges of 24-hour urinary total protein excretion in normal pregnancy are scarce.
This study aimed to determine reference ranges for 24-hour urinary total protein excretion in a population with uncomplicated singleton pregnancies using a standard method for urinary total protein. In addition, the values of 24-hour urinary total protein were stratified by maternal age and prepregnancy body mass index.
This study was based on a prospective cohort study in Shenzhen, China. The pregnant women were enrolled at their first prenatal clinical visit. All the participants were instructed to collect 24-hour urine samples during the following successive gestational periods: 6+0 to 13+6, 14+0 to 27+6, and 28+0 to 41+6 weeks. Total urinary protein excretion was analyzed by a colorimetric method. Ultimately, the study encompassed a total of 4844 pregnant women with uncomplicated pregnancies. The nonparametric percentile method was used to determine reference ranges for 24-hour urinary total protein excretion during different trimesters in women with uncomplicated pregnancies (excluding those with previous kidney disorders, gestational or chronic hypertension, preeclampsia, and pregestational diabetes mellitus, among others).
The 24-hour urinary total protein levels expressed as medians and percentiles (5th, 95th) for each trimester were as follows: 72.0 (28.4, 165.0), 88.0 (34.0, 185.0), and 108.0 (37.5, 258.0) mg in the first, second, and third trimesters, respectively. A significant increase in 24-hour urinary total protein excretion was observed throughout pregnancy (all P values <.001). Moreover, 24-hour urinary total protein levels were higher in the older (≥35 years) than in the younger (<35 years) group from mid-gestation. Specifically, the median (interquartile range) 24-hour urinary total protein levels by age were 72.2 (50.6–100.0) vs 70.5 (50.5–100.0) mg, 85.8 (62.0–117.0) vs 96.0 (68.0–127.8) mg, and 106.6 (76.0–146.2) vs 114.7 (81.5–153.6) mg in the first, second, and third trimesters, respectively. In addition, 24-hour proteinuria was significantly increased in higher-weight (overweight or obese) subgroups compared with lower-weight (underweight or normal-weight) subgroups (all P values <.05).
Our study provides reference values for 24-hour urinary total protein excretion with apparently uncomplicated pregnancies. Understanding these changes in low-risk pregnancies is essential for optimizing maternal management.
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| subjects | 24-hour urinary total protein excretion Adult Body Mass Index China Cohort Studies Female Humans Maternal Age Pregnancy Pregnancy Trimesters - urine Prospective Studies Proteinuria - urine reference ranges Reference Values uncomplicated pregnant women Young Adult |
| title | Twenty-four-hour urinary protein excretion in uncomplicated singleton pregnancy |
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