An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex

Abstract Nucleotide analogues (NA) are currently employed for treatment of several viral diseases, including COVID-19. NA prodrugs are intracellularly activated to the 5′-triphosphate form. They are incorporated into the viral RNA by the viral polymerase (SARS-CoV-2 nsp12), terminating or corrupting...

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Veröffentlicht in:	Nucleic acids research 2024-02, Vol.52 (3), p.1325-1340
Hauptverfasser:	Shannon, Ashleigh, Chazot, Aurélie, Feracci, Mikael, Falcou, Camille, Fattorini, Véronique, Selisko, Barbara, Good, Steven, Moussa, Adel, Sommadossi, Jean-Pierre, Ferron, François, Alvarez, Karine, Canard, Bruno
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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