Role of antioxidative activity in the docosahexaenoic acid’s enteroprotective effect in the indomethacin-induced small intestinal injury model

Therapeutic effect of non-steroidal anti-inflammatory drugs (NSAIDs) has been related with gastrointestinal injury. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid (PUFA), can prevent gastric and small intestinal damage. Nonetheless, contribution of antioxidative action in the prot...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024-06, Vol.397 (6), p.4275-4285
Hauptverfasser:	Sánchez-Trigueros, Martha Ivonne, Martínez-Vieyra, Ivette Astrid, Pineda-Peña, Elizabeth Arlen, Castañeda-Hernández, Gilberto, Perez-Cruz, Claudia, Cerecedo, Doris, Chávez-Piña, Aracely Evangelina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antioxidants - pharmacology Biomedical and Life Sciences Biomedicine Disease Models, Animal Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Female Glutathione Glutathione - metabolism Indomethacin Indomethacin - toxicity Inflammation Intestinal Diseases - chemically induced Intestinal Diseases - drug therapy Intestinal Diseases - metabolism Intestinal Diseases - pathology Intestinal Diseases - prevention & control Intestine, Small - drug effects Intestine, Small - metabolism Intestine, Small - pathology Leukotrienes - metabolism Lipopolysaccharides Lipopolysaccharides - toxicity Malondialdehyde - metabolism Neurosciences Nonsteroidal anti-inflammatory drugs Omeprazole Omeprazole - pharmacology Oxidative stress Oxidative Stress - drug effects Peroxidase Peroxidase - metabolism Pharmacology/Toxicology Polyunsaturated fatty acids Rats Rats, Wistar Small intestine Superoxide dismutase Superoxide Dismutase - metabolism Ulcers
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