Involved-Site Radiation Therapy Enables Effective Disease Control in Parenchymal Low-Grade Primary Cerebral Lymphoma
Primary lymphoma of the central nervous system (PCNSL) encompasses a variety of lymphoma subtypes, with the majority being diffuse large B-cell lymphomas, which require aggressive systemic treatment. In contrast, low-grade lymphomas are reported infrequently and are mostly limited to dural manifesta...
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| Veröffentlicht in: | Cancers 2023-11, Vol.15 (23), p.5564 |
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| creator | Pepper, Niklas Benedikt Oertel, Michael Reinartz, Gabriele Elsayad, Khaled Hering, Dominik Alexander Yalcin, Fatih Wildgruber, Moritz Stummer, Walter Lenz, Georg Klapper, Wolfram Eich, Hans Theodor |
| description | Primary lymphoma of the central nervous system (PCNSL) encompasses a variety of lymphoma subtypes, with the majority being diffuse large B-cell lymphomas, which require aggressive systemic treatment. In contrast, low-grade lymphomas are reported infrequently and are mostly limited to dural manifestations. Very rarely, parenchymal low-grade PCNSL is diagnosed, and the cases documented in the literature show a wide variety of treatment approaches.
We screened all cases of PCNSL treated at our department (a tertiary hematooncology and neurooncology center) in the last 15 years and conducted a comprehensive literature research in the PubMed database.
Overall, two cases of low-grade primary parenchymal PCNSL treated with irradiation were identified. The dose prescriptions ranged from 30.6 to 36 Gy for the involved site, with sparing of the hippocampal structures. Both patients had an excellent response to the treatment with a mean follow-up of 20 months. No clinical or radiological signs of treatment toxicity were detected.
Our analysis corroborates the results from the literature and demonstrates that parenchymal low-grade PCNSL shows a good response to localized radiation treatment, enabling a favorable outcome while avoiding long-term treatment toxicity. |
| doi_str_mv | 10.3390/cancers15235564 |
| format | Article |
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We screened all cases of PCNSL treated at our department (a tertiary hematooncology and neurooncology center) in the last 15 years and conducted a comprehensive literature research in the PubMed database.
Overall, two cases of low-grade primary parenchymal PCNSL treated with irradiation were identified. The dose prescriptions ranged from 30.6 to 36 Gy for the involved site, with sparing of the hippocampal structures. Both patients had an excellent response to the treatment with a mean follow-up of 20 months. No clinical or radiological signs of treatment toxicity were detected.
Our analysis corroborates the results from the literature and demonstrates that parenchymal low-grade PCNSL shows a good response to localized radiation treatment, enabling a favorable outcome while avoiding long-term treatment toxicity.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15235564</identifier><identifier>PMID: 38067268</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>B-cell lymphoma ; Biopsy ; Bone marrow ; Cancer ; Care and treatment ; Central nervous system ; Chemotherapy ; Disease control ; Hippocampus ; Hospitals ; Literature reviews ; Lymphocytes B ; Lymphoma ; Medical colleges ; Morphology ; Oncology ; Patients ; Planning ; Radiation ; Radiation therapy ; Radiotherapy ; Remission (Medicine) ; Spinal cord ; Toxicity</subject><ispartof>Cancers, 2023-11, Vol.15 (23), p.5564</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c387t-2a48d5790ea993d32ae67e297dadfa37e2d46bb0698e7c898c142abcdfa0c7f43</cites><orcidid>0000-0002-5917-4203 ; 0000-0002-2786-7013 ; 0000-0001-9303-7336 ; 0000-0002-4869-5986 ; 0000-0002-7228-6963 ; 0000-0002-5131-1859</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38067268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pepper, Niklas Benedikt</creatorcontrib><creatorcontrib>Oertel, Michael</creatorcontrib><creatorcontrib>Reinartz, Gabriele</creatorcontrib><creatorcontrib>Elsayad, Khaled</creatorcontrib><creatorcontrib>Hering, Dominik Alexander</creatorcontrib><creatorcontrib>Yalcin, Fatih</creatorcontrib><creatorcontrib>Wildgruber, Moritz</creatorcontrib><creatorcontrib>Stummer, Walter</creatorcontrib><creatorcontrib>Lenz, Georg</creatorcontrib><creatorcontrib>Klapper, Wolfram</creatorcontrib><creatorcontrib>Eich, Hans Theodor</creatorcontrib><title>Involved-Site Radiation Therapy Enables Effective Disease Control in Parenchymal Low-Grade Primary Cerebral Lymphoma</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Primary lymphoma of the central nervous system (PCNSL) encompasses a variety of lymphoma subtypes, with the majority being diffuse large B-cell lymphomas, which require aggressive systemic treatment. In contrast, low-grade lymphomas are reported infrequently and are mostly limited to dural manifestations. Very rarely, parenchymal low-grade PCNSL is diagnosed, and the cases documented in the literature show a wide variety of treatment approaches.
We screened all cases of PCNSL treated at our department (a tertiary hematooncology and neurooncology center) in the last 15 years and conducted a comprehensive literature research in the PubMed database.
Overall, two cases of low-grade primary parenchymal PCNSL treated with irradiation were identified. The dose prescriptions ranged from 30.6 to 36 Gy for the involved site, with sparing of the hippocampal structures. Both patients had an excellent response to the treatment with a mean follow-up of 20 months. No clinical or radiological signs of treatment toxicity were detected.
Our analysis corroborates the results from the literature and demonstrates that parenchymal low-grade PCNSL shows a good response to localized radiation treatment, enabling a favorable outcome while avoiding long-term treatment toxicity.</description><subject>B-cell lymphoma</subject><subject>Biopsy</subject><subject>Bone marrow</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Central nervous system</subject><subject>Chemotherapy</subject><subject>Disease control</subject><subject>Hippocampus</subject><subject>Hospitals</subject><subject>Literature reviews</subject><subject>Lymphocytes B</subject><subject>Lymphoma</subject><subject>Medical colleges</subject><subject>Morphology</subject><subject>Oncology</subject><subject>Patients</subject><subject>Planning</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><subject>Remission (Medicine)</subject><subject>Spinal cord</subject><subject>Toxicity</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU1v1DAQhiMEolXpmRuyxIVLWsdO_HGslqVUWokKytma2BPWVWIvdnbR_nu82rZAxfjgked5Z0Z-q-ptQy841_TSQrCYctMx3nWifVGdMipZLYRuX_6Vn1TnOd_TEpw3UsjX1QlXVEgm1Gk134RdHHfo6m9-RvIVnIfZx0Du1phgsyfLAP2ImSyHAe3sd0g--oyQkSximFMciQ_kFhIGu95PMJJV_FVfJ3BIbpOfIO3JAhP26VDaT5t1nOBN9WqAMeP5w31Wff-0vFt8rldfrm8WV6vaciXnmkGrXCc1RdCaO84AhUSmpQM3AC-pa0XfU6EVSqu0sk3LoLelSK0cWn5WfTj23aT4c4t5NpPPFscRAsZtNkxTplvedLKg75-h93GbQtnOMKV1S1XT8D_UDxjR-DDEOYE9NDVXUnaqBD2MvfgPVY7DydsYcPDl_R_B5VFgU8w54WA2x68zDTUHq80zq4vi3cO6235C98Q_Gst_A2Y1pPk</recordid><startdate>20231124</startdate><enddate>20231124</enddate><creator>Pepper, Niklas Benedikt</creator><creator>Oertel, Michael</creator><creator>Reinartz, Gabriele</creator><creator>Elsayad, Khaled</creator><creator>Hering, Dominik Alexander</creator><creator>Yalcin, Fatih</creator><creator>Wildgruber, Moritz</creator><creator>Stummer, Walter</creator><creator>Lenz, Georg</creator><creator>Klapper, Wolfram</creator><creator>Eich, Hans Theodor</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5917-4203</orcidid><orcidid>https://orcid.org/0000-0002-2786-7013</orcidid><orcidid>https://orcid.org/0000-0001-9303-7336</orcidid><orcidid>https://orcid.org/0000-0002-4869-5986</orcidid><orcidid>https://orcid.org/0000-0002-7228-6963</orcidid><orcidid>https://orcid.org/0000-0002-5131-1859</orcidid></search><sort><creationdate>20231124</creationdate><title>Involved-Site Radiation Therapy Enables Effective Disease Control in Parenchymal Low-Grade Primary Cerebral Lymphoma</title><author>Pepper, Niklas Benedikt ; Oertel, Michael ; Reinartz, Gabriele ; Elsayad, Khaled ; Hering, Dominik Alexander ; Yalcin, Fatih ; Wildgruber, Moritz ; Stummer, Walter ; Lenz, Georg ; Klapper, Wolfram ; Eich, Hans Theodor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-2a48d5790ea993d32ae67e297dadfa37e2d46bb0698e7c898c142abcdfa0c7f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>B-cell lymphoma</topic><topic>Biopsy</topic><topic>Bone marrow</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Central nervous system</topic><topic>Chemotherapy</topic><topic>Disease control</topic><topic>Hippocampus</topic><topic>Hospitals</topic><topic>Literature reviews</topic><topic>Lymphocytes B</topic><topic>Lymphoma</topic><topic>Medical colleges</topic><topic>Morphology</topic><topic>Oncology</topic><topic>Patients</topic><topic>Planning</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Radiotherapy</topic><topic>Remission (Medicine)</topic><topic>Spinal cord</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pepper, Niklas Benedikt</creatorcontrib><creatorcontrib>Oertel, Michael</creatorcontrib><creatorcontrib>Reinartz, Gabriele</creatorcontrib><creatorcontrib>Elsayad, Khaled</creatorcontrib><creatorcontrib>Hering, Dominik Alexander</creatorcontrib><creatorcontrib>Yalcin, Fatih</creatorcontrib><creatorcontrib>Wildgruber, Moritz</creatorcontrib><creatorcontrib>Stummer, Walter</creatorcontrib><creatorcontrib>Lenz, Georg</creatorcontrib><creatorcontrib>Klapper, Wolfram</creatorcontrib><creatorcontrib>Eich, Hans Theodor</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pepper, Niklas Benedikt</au><au>Oertel, Michael</au><au>Reinartz, Gabriele</au><au>Elsayad, Khaled</au><au>Hering, Dominik Alexander</au><au>Yalcin, Fatih</au><au>Wildgruber, Moritz</au><au>Stummer, Walter</au><au>Lenz, Georg</au><au>Klapper, Wolfram</au><au>Eich, Hans Theodor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involved-Site Radiation Therapy Enables Effective Disease Control in Parenchymal Low-Grade Primary Cerebral Lymphoma</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2023-11-24</date><risdate>2023</risdate><volume>15</volume><issue>23</issue><spage>5564</spage><pages>5564-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Primary lymphoma of the central nervous system (PCNSL) encompasses a variety of lymphoma subtypes, with the majority being diffuse large B-cell lymphomas, which require aggressive systemic treatment. In contrast, low-grade lymphomas are reported infrequently and are mostly limited to dural manifestations. Very rarely, parenchymal low-grade PCNSL is diagnosed, and the cases documented in the literature show a wide variety of treatment approaches.
We screened all cases of PCNSL treated at our department (a tertiary hematooncology and neurooncology center) in the last 15 years and conducted a comprehensive literature research in the PubMed database.
Overall, two cases of low-grade primary parenchymal PCNSL treated with irradiation were identified. The dose prescriptions ranged from 30.6 to 36 Gy for the involved site, with sparing of the hippocampal structures. Both patients had an excellent response to the treatment with a mean follow-up of 20 months. No clinical or radiological signs of treatment toxicity were detected.
Our analysis corroborates the results from the literature and demonstrates that parenchymal low-grade PCNSL shows a good response to localized radiation treatment, enabling a favorable outcome while avoiding long-term treatment toxicity.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38067268</pmid><doi>10.3390/cancers15235564</doi><orcidid>https://orcid.org/0000-0002-5917-4203</orcidid><orcidid>https://orcid.org/0000-0002-2786-7013</orcidid><orcidid>https://orcid.org/0000-0001-9303-7336</orcidid><orcidid>https://orcid.org/0000-0002-4869-5986</orcidid><orcidid>https://orcid.org/0000-0002-7228-6963</orcidid><orcidid>https://orcid.org/0000-0002-5131-1859</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | B-cell lymphoma Biopsy Bone marrow Cancer Care and treatment Central nervous system Chemotherapy Disease control Hippocampus Hospitals Literature reviews Lymphocytes B Lymphoma Medical colleges Morphology Oncology Patients Planning Radiation Radiation therapy Radiotherapy Remission (Medicine) Spinal cord Toxicity |
| title | Involved-Site Radiation Therapy Enables Effective Disease Control in Parenchymal Low-Grade Primary Cerebral Lymphoma |
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