Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels

Reversible cysteine modification has been found to be a useful tool for a plethora of applications such as selective enzymatic inhibition, activity-based protein profiling and/or cargo release from a protein or a material. However, only a limited number of reagents display reliable dynamic/reversibl...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical science (Cambridge) 2023-12, Vol.14 (47), p.13743-13754
Hauptverfasser:	Rochet, Léa N. C, Bahou, Calise, Wojciechowski, Jonathan P, Koutsopetras, Ilias, Britton, Phyllida, Spears, Richard J, Thanasi, Ioanna A, Shao, Baihao, Zhong, Lisha, Bu ar, Dejan-Krešimir, Aliev, Abil E, Porter, Michael J, Stevens, Molly M, Baker, James R, Chudasama, Vijay
Format:	Artikel
Sprache:	eng
Schlagworte:	Cysteine Hydrogels Modularity Peptides Proteins Reagents Regioselectivity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!