The Hepatorenal Protective Potential of Caffeic Acid Consumption on the Arsenic-Exposed Syrian Mice
Arsenic can induce lethal hepatorenal insufficiency by inducing progressive cytotoxicity in the two main body’s hemostatic regulators, the kidney and liver. In the current study, the hepatorenal protective impact of caffeic acid was investigated in arsenic-exposed Syrian mice. Twenty-four male Syria...
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| Veröffentlicht in: | Biological trace element research 2024-10, Vol.202 (10), p.4547-4553 |
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| creator | Chekneh, Fahimeh Azadi, Hamideh Ghodrati Baghshani, Hasan Moosavi, Zahra |
| description | Arsenic can induce lethal hepatorenal insufficiency by inducing progressive cytotoxicity in the two main body’s hemostatic regulators, the kidney and liver. In the current study, the hepatorenal protective impact of caffeic acid was investigated in arsenic-exposed Syrian mice. Twenty-four male Syrian mice (30
±
8 g) were provided and randomly divided into 4 groups of 6 receiving nothing, arsenic, arsenic and caffeic, and caffeic acid. The mice passed the 21-day treatment program. The mice’s blood was collected and analyzed by measuring the serum ALT/AST enzymes and creatinine/urea levels, respectively. Finally, the histopathological properties in both the kidney and liver organs of the mice were studied. Arsenic administration significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), LDH, urea, and creatinine concentrations (
p
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| doi_str_mv | 10.1007/s12011-023-04008-0 |
| format | Article |
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±
8 g) were provided and randomly divided into 4 groups of 6 receiving nothing, arsenic, arsenic and caffeic, and caffeic acid. The mice passed the 21-day treatment program. The mice’s blood was collected and analyzed by measuring the serum ALT/AST enzymes and creatinine/urea levels, respectively. Finally, the histopathological properties in both the kidney and liver organs of the mice were studied. Arsenic administration significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), LDH, urea, and creatinine concentrations (
p
< 0.05). Simultaneous administration of caffeic acid with arsenic decreased the serum AST and creatinine (
p
< 0.05). Moreover, the renal glomerulus and liver regeneration in the mice receiving caffeic acid supplements exhibited the caffeic acid hepatorenal protective potential. The histopathological changes caused by arsenic in the mice’s liver and kidney tissue including degeneration, necrosis, hyperemia, and tissue hypotrophy were shifted to normal conditions following the caffeic acid administration dose, which was verified by the mice blood biochemical analysis results.</description><identifier>ISSN: 0163-4984</identifier><identifier>ISSN: 1559-0720</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-023-04008-0</identifier><identifier>PMID: 38102533</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acids ; Alanine ; Alanine transaminase ; Animals ; Arsenic ; Arsenic - toxicity ; Aspartate aminotransferase ; Biochemical analysis ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Blood ; Body organs ; Caffeic acid ; Caffeic Acids - pharmacology ; Creatinine ; Cytotoxicity ; Degeneration ; Glomerulus ; Histopathology ; Hyperemia ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidneys ; Life Sciences ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Male ; Mice ; Necrosis ; Nutrition ; Oncology ; Protective Agents - administration & dosage ; Protective Agents - pharmacology ; Regeneration (biological) ; Serum ; Transaminases ; Urea ; Ureas</subject><ispartof>Biological trace element research, 2024-10, Vol.202 (10), p.4547-4553</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-4f980f16955fe6a239d500ce3137784348570cb31c789e41e9650350b1b45323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-023-04008-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-023-04008-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38102533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chekneh, Fahimeh</creatorcontrib><creatorcontrib>Azadi, Hamideh Ghodrati</creatorcontrib><creatorcontrib>Baghshani, Hasan</creatorcontrib><creatorcontrib>Moosavi, Zahra</creatorcontrib><title>The Hepatorenal Protective Potential of Caffeic Acid Consumption on the Arsenic-Exposed Syrian Mice</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Arsenic can induce lethal hepatorenal insufficiency by inducing progressive cytotoxicity in the two main body’s hemostatic regulators, the kidney and liver. In the current study, the hepatorenal protective impact of caffeic acid was investigated in arsenic-exposed Syrian mice. Twenty-four male Syrian mice (30
±
8 g) were provided and randomly divided into 4 groups of 6 receiving nothing, arsenic, arsenic and caffeic, and caffeic acid. The mice passed the 21-day treatment program. The mice’s blood was collected and analyzed by measuring the serum ALT/AST enzymes and creatinine/urea levels, respectively. Finally, the histopathological properties in both the kidney and liver organs of the mice were studied. Arsenic administration significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), LDH, urea, and creatinine concentrations (
p
< 0.05). Simultaneous administration of caffeic acid with arsenic decreased the serum AST and creatinine (
p
< 0.05). Moreover, the renal glomerulus and liver regeneration in the mice receiving caffeic acid supplements exhibited the caffeic acid hepatorenal protective potential. The histopathological changes caused by arsenic in the mice’s liver and kidney tissue including degeneration, necrosis, hyperemia, and tissue hypotrophy were shifted to normal conditions following the caffeic acid administration dose, which was verified by the mice blood biochemical analysis results.</description><subject>Acids</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Animals</subject><subject>Arsenic</subject><subject>Arsenic - toxicity</subject><subject>Aspartate aminotransferase</subject><subject>Biochemical analysis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood</subject><subject>Body organs</subject><subject>Caffeic acid</subject><subject>Caffeic Acids - pharmacology</subject><subject>Creatinine</subject><subject>Cytotoxicity</subject><subject>Degeneration</subject><subject>Glomerulus</subject><subject>Histopathology</subject><subject>Hyperemia</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Mice</subject><subject>Necrosis</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Protective Agents - administration & dosage</subject><subject>Protective Agents - pharmacology</subject><subject>Regeneration (biological)</subject><subject>Serum</subject><subject>Transaminases</subject><subject>Urea</subject><subject>Ureas</subject><issn>0163-4984</issn><issn>1559-0720</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGLFDEQhYMo7jj6BzxIwIuXaFUq6e4ch2F1hRUXnHvoyVRrlplOm3SL---NzqrgQQhUSH31irwnxHOE1wjQvimoAVGBJgUGoFPwQKzQWqeg1fBQrAAbUsZ15kI8KeUWAFvt6LG4oA5BW6KVCLsvLK946ueUeeyP8ianmcMcv7G8qbdxjvUxDXLbDwPHIDchHuQ2jWU5TXNMo6xnrhqbXHiMQV1-n1Lhg_x0l2M_yg8x8FPxaOiPhZ_d17XYvb3cba_U9cd377ebaxVIN7Myg-tgwMZZO3DTa3IHCxCYkNq2M2Q620LYE4a2c2yQXWOBLOxxbyxpWotXZ9kpp68Ll9mfYgl8PPYjp6V47UA7A1RNWYuX_6C3acn1-8UTOKsdIrSV0mcq5FRK5sFPOZ76fOcR_M8E_DkBXxPwvxLwUIde3Esv-xMf_oz8trwCdAZKbY2fOf_d_R_ZHzMUjlI</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Chekneh, Fahimeh</creator><creator>Azadi, Hamideh Ghodrati</creator><creator>Baghshani, Hasan</creator><creator>Moosavi, Zahra</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20241001</creationdate><title>The Hepatorenal Protective Potential of Caffeic Acid Consumption on the Arsenic-Exposed Syrian Mice</title><author>Chekneh, Fahimeh ; Azadi, Hamideh Ghodrati ; Baghshani, Hasan ; Moosavi, Zahra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-4f980f16955fe6a239d500ce3137784348570cb31c789e41e9650350b1b45323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acids</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Animals</topic><topic>Arsenic</topic><topic>Arsenic - toxicity</topic><topic>Aspartate aminotransferase</topic><topic>Biochemical analysis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Blood</topic><topic>Body organs</topic><topic>Caffeic acid</topic><topic>Caffeic Acids - pharmacology</topic><topic>Creatinine</topic><topic>Cytotoxicity</topic><topic>Degeneration</topic><topic>Glomerulus</topic><topic>Histopathology</topic><topic>Hyperemia</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Mice</topic><topic>Necrosis</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Protective Agents - administration & dosage</topic><topic>Protective Agents - pharmacology</topic><topic>Regeneration (biological)</topic><topic>Serum</topic><topic>Transaminases</topic><topic>Urea</topic><topic>Ureas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chekneh, Fahimeh</creatorcontrib><creatorcontrib>Azadi, Hamideh Ghodrati</creatorcontrib><creatorcontrib>Baghshani, Hasan</creatorcontrib><creatorcontrib>Moosavi, Zahra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chekneh, Fahimeh</au><au>Azadi, Hamideh Ghodrati</au><au>Baghshani, Hasan</au><au>Moosavi, Zahra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Hepatorenal Protective Potential of Caffeic Acid Consumption on the Arsenic-Exposed Syrian Mice</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>202</volume><issue>10</issue><spage>4547</spage><epage>4553</epage><pages>4547-4553</pages><issn>0163-4984</issn><issn>1559-0720</issn><eissn>1559-0720</eissn><abstract>Arsenic can induce lethal hepatorenal insufficiency by inducing progressive cytotoxicity in the two main body’s hemostatic regulators, the kidney and liver. In the current study, the hepatorenal protective impact of caffeic acid was investigated in arsenic-exposed Syrian mice. Twenty-four male Syrian mice (30
±
8 g) were provided and randomly divided into 4 groups of 6 receiving nothing, arsenic, arsenic and caffeic, and caffeic acid. The mice passed the 21-day treatment program. The mice’s blood was collected and analyzed by measuring the serum ALT/AST enzymes and creatinine/urea levels, respectively. Finally, the histopathological properties in both the kidney and liver organs of the mice were studied. Arsenic administration significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), LDH, urea, and creatinine concentrations (
p
< 0.05). Simultaneous administration of caffeic acid with arsenic decreased the serum AST and creatinine (
p
< 0.05). Moreover, the renal glomerulus and liver regeneration in the mice receiving caffeic acid supplements exhibited the caffeic acid hepatorenal protective potential. The histopathological changes caused by arsenic in the mice’s liver and kidney tissue including degeneration, necrosis, hyperemia, and tissue hypotrophy were shifted to normal conditions following the caffeic acid administration dose, which was verified by the mice blood biochemical analysis results.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38102533</pmid><doi>10.1007/s12011-023-04008-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Acids Alanine Alanine transaminase Animals Arsenic Arsenic - toxicity Aspartate aminotransferase Biochemical analysis Biochemistry Biomedical and Life Sciences Biotechnology Blood Body organs Caffeic acid Caffeic Acids - pharmacology Creatinine Cytotoxicity Degeneration Glomerulus Histopathology Hyperemia Kidney - drug effects Kidney - metabolism Kidney - pathology Kidneys Life Sciences Liver Liver - drug effects Liver - metabolism Liver - pathology Male Mice Necrosis Nutrition Oncology Protective Agents - administration & dosage Protective Agents - pharmacology Regeneration (biological) Serum Transaminases Urea Ureas |
| title | The Hepatorenal Protective Potential of Caffeic Acid Consumption on the Arsenic-Exposed Syrian Mice |
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