Endothelial Cell Calcium Influx Mediates Trauma-induced Endothelial Permeability

Endothelial Cell Calcium Influx Mediates Trauma-induced Endothelial Permeability

We aimed to investigate if ex vivo plasma from injured patients causes endothelial calcium (Ca2+) influx as a mechanism of trauma-induced endothelial permeability. Endothelial permeability after trauma contributes to post-injury organ dysfunction. While the mechanisms remain unclear, emerging eviden...

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Veröffentlicht in:Annals of surgery 2023-12
Hauptverfasser: Schaid, Jr, Terry R, Mitra, Sanchayita, Stafford, Preston, DeBot, Margot, Thielen, Otto, Hallas, William, Cralley, Alexis, Gallagher, Lauren, Jeffrey, Danielle, Hansen, Kirk C, D'Alessandro, Angelo, Silliman, Christopher C, Dabertrand, Fabrice, Cohen, Mitchell J
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Sprache:eng
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Zusammenfassung:We aimed to investigate if ex vivo plasma from injured patients causes endothelial calcium (Ca2+) influx as a mechanism of trauma-induced endothelial permeability. Endothelial permeability after trauma contributes to post-injury organ dysfunction. While the mechanisms remain unclear, emerging evidence suggests intracellular Ca2+ signaling may play a role. Ex vivo plasma from injured patients with "Low Injury/Low Shock" (injury severity score [ISS]
ISSN:0003-4932
1528-1140
1528-1140
DOI:10.1097/SLA.0000000000006164