Safety and feasibility of same‐day discharge following uncomplicated transvenous lead extraction

Introduction Transvenous lead extraction (TLE), while mostly a safe procedure, has risk of serious periprocedural complications. As such, overnight hospitalization remains a routine practice. In our center, we routinely discharge patients on the same day following an uncomplicated TLE. Methods This...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of cardiovascular electrophysiology 2024-02, Vol.35 (2), p.278-287
Hauptverfasser: Gianni, Carola, Elchouemi, Mohanad, Helmy, Rami, Spinetta, Lauryn, La Fazia, Vincenzo Mirco, Pierucci, Nicola, Asfour, Issa, Della Rocca, Domenico G., Mohanty, Sanghamitra, Bassiouny, Mohamed A., Coffeen, Paul C., Hranitzky, Patrick M., Neely, Robert C., Natale, Andrea, Canby, Robert C., Al‐Ahmad, Amin
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 287
container_issue 2
container_start_page 278
container_title Journal of cardiovascular electrophysiology
container_volume 35
creator Gianni, Carola
Elchouemi, Mohanad
Helmy, Rami
Spinetta, Lauryn
La Fazia, Vincenzo Mirco
Pierucci, Nicola
Asfour, Issa
Della Rocca, Domenico G.
Mohanty, Sanghamitra
Bassiouny, Mohamed A.
Coffeen, Paul C.
Hranitzky, Patrick M.
Neely, Robert C.
Natale, Andrea
Canby, Robert C.
Al‐Ahmad, Amin
description Introduction Transvenous lead extraction (TLE), while mostly a safe procedure, has risk of serious periprocedural complications. As such, overnight hospitalization remains a routine practice. In our center, we routinely discharge patients on the same day following an uncomplicated TLE. Methods This is a retrospective study of 265 consecutive patients who underwent uncomplicated TLE in our center between 2019 and 2021. Same‐day discharge (SDD) patients are compared with those who stayed at least overnight for observation after the TLE procedure (non‐SDD group). To assess the safety of an SDD strategy after uncomplicated TLE, the main study endpoint was to compare the rate of major procedure‐related complications at 1‐, 7‐, and 30‐days. To identify the factors influencing the operator's decision to discharge the patient on the same day, the secondary endpoint was to analyze clinical and procedural predictors of SDD. Results A total of 153 patients were discharged the same day after uncomplicated TLE (SDD), while 112 stayed at least overnight after the procedure (non‐SDD). There was no significant difference in major procedure‐related complications at 1‐day (SDD 0% vs. non‐SDD 1.8%, p value = ns), while patients in the SDD group had a lower rate of 7‐ and 30‐day complications when compared with those in the non‐SDD group (2.1% vs. 8.2%, p value = .0308; and 3.5% vs. 16%, p value = .0049, respectively). Noninfectious indication for TLE (OR 16.1, 95% confidence interval [CI] 4.29–77.6) and procedure end time before 12:00 (OR 2.82, 95% CI 1.11–7.27) were the only independent predictors of SDD. Conclusion SDD discharge following uncomplicated TLE in selected patients (i.e., those without device infection and when the TLE procedure is completed in the morning) is feasible and safe.
doi_str_mv 10.1111/jce.16147
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2902939061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2922241937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3887-48a7e08bc764ac218f108b063dfbb9537ad6ad277d6f01832569f7d8029c4483</originalsourceid><addsrcrecordid>eNp10MtOxCAUBmBiNN4XvoAhcaOLKpQW6NJMvMbEhe4bCgdlQstYWsfZ-Qg-o08iOurCRDZwyJc_Jz9Ce5Qc03ROphqOKaeFWEGbtCxIJikXq-lNijJjUrANtBXjlBDKOCnX0QaTRDBS0k3U3CkLwwKrzmALKrrGeZfmYHFULby_vhm1wMZF_aj6B8A2eB_mrnvAY6dDO_NOqwEMHnrVxWfowhixB2UwvKQvPbjQ7aA1q3yE3e97G92fn91PLrOb24uryelNppmUIiukEkBkowUvlM6ptDRNhDNjm6YqmVCGK5MLYbglVLK85JUVRpK80kUh2TY6XMbO-vA0QhzqNm0N3qsO0lZ1XiXJKsJpogd_6DSMfZeWSyrP84JWTCR1tFS6DzH2YOtZ71rVL2pK6s_e69R7_dV7svvfiWPTgvmVP0UncLIEc-dh8X9SfT05W0Z-AKXhjVM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2922241937</pqid></control><display><type>article</type><title>Safety and feasibility of same‐day discharge following uncomplicated transvenous lead extraction</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Gianni, Carola ; Elchouemi, Mohanad ; Helmy, Rami ; Spinetta, Lauryn ; La Fazia, Vincenzo Mirco ; Pierucci, Nicola ; Asfour, Issa ; Della Rocca, Domenico G. ; Mohanty, Sanghamitra ; Bassiouny, Mohamed A. ; Coffeen, Paul C. ; Hranitzky, Patrick M. ; Neely, Robert C. ; Natale, Andrea ; Canby, Robert C. ; Al‐Ahmad, Amin</creator><creatorcontrib>Gianni, Carola ; Elchouemi, Mohanad ; Helmy, Rami ; Spinetta, Lauryn ; La Fazia, Vincenzo Mirco ; Pierucci, Nicola ; Asfour, Issa ; Della Rocca, Domenico G. ; Mohanty, Sanghamitra ; Bassiouny, Mohamed A. ; Coffeen, Paul C. ; Hranitzky, Patrick M. ; Neely, Robert C. ; Natale, Andrea ; Canby, Robert C. ; Al‐Ahmad, Amin</creatorcontrib><description>Introduction Transvenous lead extraction (TLE), while mostly a safe procedure, has risk of serious periprocedural complications. As such, overnight hospitalization remains a routine practice. In our center, we routinely discharge patients on the same day following an uncomplicated TLE. Methods This is a retrospective study of 265 consecutive patients who underwent uncomplicated TLE in our center between 2019 and 2021. Same‐day discharge (SDD) patients are compared with those who stayed at least overnight for observation after the TLE procedure (non‐SDD group). To assess the safety of an SDD strategy after uncomplicated TLE, the main study endpoint was to compare the rate of major procedure‐related complications at 1‐, 7‐, and 30‐days. To identify the factors influencing the operator's decision to discharge the patient on the same day, the secondary endpoint was to analyze clinical and procedural predictors of SDD. Results A total of 153 patients were discharged the same day after uncomplicated TLE (SDD), while 112 stayed at least overnight after the procedure (non‐SDD). There was no significant difference in major procedure‐related complications at 1‐day (SDD 0% vs. non‐SDD 1.8%, p value = ns), while patients in the SDD group had a lower rate of 7‐ and 30‐day complications when compared with those in the non‐SDD group (2.1% vs. 8.2%, p value = .0308; and 3.5% vs. 16%, p value = .0049, respectively). Noninfectious indication for TLE (OR 16.1, 95% confidence interval [CI] 4.29–77.6) and procedure end time before 12:00 (OR 2.82, 95% CI 1.11–7.27) were the only independent predictors of SDD. Conclusion SDD discharge following uncomplicated TLE in selected patients (i.e., those without device infection and when the TLE procedure is completed in the morning) is feasible and safe.</description><identifier>ISSN: 1045-3873</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1111/jce.16147</identifier><identifier>PMID: 38073051</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>cardiac implantable electronic devices ; Clinical decision making ; Device Removal - adverse effects ; Feasibility Studies ; Hospitalization ; Humans ; Patient Discharge ; Retrospective Studies ; same‐day discharge ; transvenous lead extraction ; Treatment Outcome</subject><ispartof>Journal of cardiovascular electrophysiology, 2024-02, Vol.35 (2), p.278-287</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. Journal of Cardiovascular Electrophysiology published by Wiley Periodicals LLC.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-48a7e08bc764ac218f108b063dfbb9537ad6ad277d6f01832569f7d8029c4483</citedby><cites>FETCH-LOGICAL-c3887-48a7e08bc764ac218f108b063dfbb9537ad6ad277d6f01832569f7d8029c4483</cites><orcidid>0000-0001-6601-944X ; 0000-0002-3482-9875 ; 0000-0002-8174-7207 ; 0000-0002-8547-025X ; 0000-0002-5487-0728</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjce.16147$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjce.16147$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38073051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gianni, Carola</creatorcontrib><creatorcontrib>Elchouemi, Mohanad</creatorcontrib><creatorcontrib>Helmy, Rami</creatorcontrib><creatorcontrib>Spinetta, Lauryn</creatorcontrib><creatorcontrib>La Fazia, Vincenzo Mirco</creatorcontrib><creatorcontrib>Pierucci, Nicola</creatorcontrib><creatorcontrib>Asfour, Issa</creatorcontrib><creatorcontrib>Della Rocca, Domenico G.</creatorcontrib><creatorcontrib>Mohanty, Sanghamitra</creatorcontrib><creatorcontrib>Bassiouny, Mohamed A.</creatorcontrib><creatorcontrib>Coffeen, Paul C.</creatorcontrib><creatorcontrib>Hranitzky, Patrick M.</creatorcontrib><creatorcontrib>Neely, Robert C.</creatorcontrib><creatorcontrib>Natale, Andrea</creatorcontrib><creatorcontrib>Canby, Robert C.</creatorcontrib><creatorcontrib>Al‐Ahmad, Amin</creatorcontrib><title>Safety and feasibility of same‐day discharge following uncomplicated transvenous lead extraction</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description>Introduction Transvenous lead extraction (TLE), while mostly a safe procedure, has risk of serious periprocedural complications. As such, overnight hospitalization remains a routine practice. In our center, we routinely discharge patients on the same day following an uncomplicated TLE. Methods This is a retrospective study of 265 consecutive patients who underwent uncomplicated TLE in our center between 2019 and 2021. Same‐day discharge (SDD) patients are compared with those who stayed at least overnight for observation after the TLE procedure (non‐SDD group). To assess the safety of an SDD strategy after uncomplicated TLE, the main study endpoint was to compare the rate of major procedure‐related complications at 1‐, 7‐, and 30‐days. To identify the factors influencing the operator's decision to discharge the patient on the same day, the secondary endpoint was to analyze clinical and procedural predictors of SDD. Results A total of 153 patients were discharged the same day after uncomplicated TLE (SDD), while 112 stayed at least overnight after the procedure (non‐SDD). There was no significant difference in major procedure‐related complications at 1‐day (SDD 0% vs. non‐SDD 1.8%, p value = ns), while patients in the SDD group had a lower rate of 7‐ and 30‐day complications when compared with those in the non‐SDD group (2.1% vs. 8.2%, p value = .0308; and 3.5% vs. 16%, p value = .0049, respectively). Noninfectious indication for TLE (OR 16.1, 95% confidence interval [CI] 4.29–77.6) and procedure end time before 12:00 (OR 2.82, 95% CI 1.11–7.27) were the only independent predictors of SDD. Conclusion SDD discharge following uncomplicated TLE in selected patients (i.e., those without device infection and when the TLE procedure is completed in the morning) is feasible and safe.</description><subject>cardiac implantable electronic devices</subject><subject>Clinical decision making</subject><subject>Device Removal - adverse effects</subject><subject>Feasibility Studies</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Patient Discharge</subject><subject>Retrospective Studies</subject><subject>same‐day discharge</subject><subject>transvenous lead extraction</subject><subject>Treatment Outcome</subject><issn>1045-3873</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp10MtOxCAUBmBiNN4XvoAhcaOLKpQW6NJMvMbEhe4bCgdlQstYWsfZ-Qg-o08iOurCRDZwyJc_Jz9Ce5Qc03ROphqOKaeFWEGbtCxIJikXq-lNijJjUrANtBXjlBDKOCnX0QaTRDBS0k3U3CkLwwKrzmALKrrGeZfmYHFULby_vhm1wMZF_aj6B8A2eB_mrnvAY6dDO_NOqwEMHnrVxWfowhixB2UwvKQvPbjQ7aA1q3yE3e97G92fn91PLrOb24uryelNppmUIiukEkBkowUvlM6ptDRNhDNjm6YqmVCGK5MLYbglVLK85JUVRpK80kUh2TY6XMbO-vA0QhzqNm0N3qsO0lZ1XiXJKsJpogd_6DSMfZeWSyrP84JWTCR1tFS6DzH2YOtZ71rVL2pK6s_e69R7_dV7svvfiWPTgvmVP0UncLIEc-dh8X9SfT05W0Z-AKXhjVM</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Gianni, Carola</creator><creator>Elchouemi, Mohanad</creator><creator>Helmy, Rami</creator><creator>Spinetta, Lauryn</creator><creator>La Fazia, Vincenzo Mirco</creator><creator>Pierucci, Nicola</creator><creator>Asfour, Issa</creator><creator>Della Rocca, Domenico G.</creator><creator>Mohanty, Sanghamitra</creator><creator>Bassiouny, Mohamed A.</creator><creator>Coffeen, Paul C.</creator><creator>Hranitzky, Patrick M.</creator><creator>Neely, Robert C.</creator><creator>Natale, Andrea</creator><creator>Canby, Robert C.</creator><creator>Al‐Ahmad, Amin</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6601-944X</orcidid><orcidid>https://orcid.org/0000-0002-3482-9875</orcidid><orcidid>https://orcid.org/0000-0002-8174-7207</orcidid><orcidid>https://orcid.org/0000-0002-8547-025X</orcidid><orcidid>https://orcid.org/0000-0002-5487-0728</orcidid></search><sort><creationdate>202402</creationdate><title>Safety and feasibility of same‐day discharge following uncomplicated transvenous lead extraction</title><author>Gianni, Carola ; Elchouemi, Mohanad ; Helmy, Rami ; Spinetta, Lauryn ; La Fazia, Vincenzo Mirco ; Pierucci, Nicola ; Asfour, Issa ; Della Rocca, Domenico G. ; Mohanty, Sanghamitra ; Bassiouny, Mohamed A. ; Coffeen, Paul C. ; Hranitzky, Patrick M. ; Neely, Robert C. ; Natale, Andrea ; Canby, Robert C. ; Al‐Ahmad, Amin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-48a7e08bc764ac218f108b063dfbb9537ad6ad277d6f01832569f7d8029c4483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>cardiac implantable electronic devices</topic><topic>Clinical decision making</topic><topic>Device Removal - adverse effects</topic><topic>Feasibility Studies</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Patient Discharge</topic><topic>Retrospective Studies</topic><topic>same‐day discharge</topic><topic>transvenous lead extraction</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gianni, Carola</creatorcontrib><creatorcontrib>Elchouemi, Mohanad</creatorcontrib><creatorcontrib>Helmy, Rami</creatorcontrib><creatorcontrib>Spinetta, Lauryn</creatorcontrib><creatorcontrib>La Fazia, Vincenzo Mirco</creatorcontrib><creatorcontrib>Pierucci, Nicola</creatorcontrib><creatorcontrib>Asfour, Issa</creatorcontrib><creatorcontrib>Della Rocca, Domenico G.</creatorcontrib><creatorcontrib>Mohanty, Sanghamitra</creatorcontrib><creatorcontrib>Bassiouny, Mohamed A.</creatorcontrib><creatorcontrib>Coffeen, Paul C.</creatorcontrib><creatorcontrib>Hranitzky, Patrick M.</creatorcontrib><creatorcontrib>Neely, Robert C.</creatorcontrib><creatorcontrib>Natale, Andrea</creatorcontrib><creatorcontrib>Canby, Robert C.</creatorcontrib><creatorcontrib>Al‐Ahmad, Amin</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gianni, Carola</au><au>Elchouemi, Mohanad</au><au>Helmy, Rami</au><au>Spinetta, Lauryn</au><au>La Fazia, Vincenzo Mirco</au><au>Pierucci, Nicola</au><au>Asfour, Issa</au><au>Della Rocca, Domenico G.</au><au>Mohanty, Sanghamitra</au><au>Bassiouny, Mohamed A.</au><au>Coffeen, Paul C.</au><au>Hranitzky, Patrick M.</au><au>Neely, Robert C.</au><au>Natale, Andrea</au><au>Canby, Robert C.</au><au>Al‐Ahmad, Amin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and feasibility of same‐day discharge following uncomplicated transvenous lead extraction</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>2024-02</date><risdate>2024</risdate><volume>35</volume><issue>2</issue><spage>278</spage><epage>287</epage><pages>278-287</pages><issn>1045-3873</issn><eissn>1540-8167</eissn><abstract>Introduction Transvenous lead extraction (TLE), while mostly a safe procedure, has risk of serious periprocedural complications. As such, overnight hospitalization remains a routine practice. In our center, we routinely discharge patients on the same day following an uncomplicated TLE. Methods This is a retrospective study of 265 consecutive patients who underwent uncomplicated TLE in our center between 2019 and 2021. Same‐day discharge (SDD) patients are compared with those who stayed at least overnight for observation after the TLE procedure (non‐SDD group). To assess the safety of an SDD strategy after uncomplicated TLE, the main study endpoint was to compare the rate of major procedure‐related complications at 1‐, 7‐, and 30‐days. To identify the factors influencing the operator's decision to discharge the patient on the same day, the secondary endpoint was to analyze clinical and procedural predictors of SDD. Results A total of 153 patients were discharged the same day after uncomplicated TLE (SDD), while 112 stayed at least overnight after the procedure (non‐SDD). There was no significant difference in major procedure‐related complications at 1‐day (SDD 0% vs. non‐SDD 1.8%, p value = ns), while patients in the SDD group had a lower rate of 7‐ and 30‐day complications when compared with those in the non‐SDD group (2.1% vs. 8.2%, p value = .0308; and 3.5% vs. 16%, p value = .0049, respectively). Noninfectious indication for TLE (OR 16.1, 95% confidence interval [CI] 4.29–77.6) and procedure end time before 12:00 (OR 2.82, 95% CI 1.11–7.27) were the only independent predictors of SDD. Conclusion SDD discharge following uncomplicated TLE in selected patients (i.e., those without device infection and when the TLE procedure is completed in the morning) is feasible and safe.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38073051</pmid><doi>10.1111/jce.16147</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6601-944X</orcidid><orcidid>https://orcid.org/0000-0002-3482-9875</orcidid><orcidid>https://orcid.org/0000-0002-8174-7207</orcidid><orcidid>https://orcid.org/0000-0002-8547-025X</orcidid><orcidid>https://orcid.org/0000-0002-5487-0728</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1045-3873
ispartof Journal of cardiovascular electrophysiology, 2024-02, Vol.35 (2), p.278-287
issn 1045-3873
1540-8167
language eng
recordid cdi_proquest_miscellaneous_2902939061
source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects cardiac implantable electronic devices
Clinical decision making
Device Removal - adverse effects
Feasibility Studies
Hospitalization
Humans
Patient Discharge
Retrospective Studies
same‐day discharge
transvenous lead extraction
Treatment Outcome
title Safety and feasibility of same‐day discharge following uncomplicated transvenous lead extraction
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A51%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Safety%20and%20feasibility%20of%20same%E2%80%90day%20discharge%20following%20uncomplicated%20transvenous%20lead%20extraction&rft.jtitle=Journal%20of%20cardiovascular%20electrophysiology&rft.au=Gianni,%20Carola&rft.date=2024-02&rft.volume=35&rft.issue=2&rft.spage=278&rft.epage=287&rft.pages=278-287&rft.issn=1045-3873&rft.eissn=1540-8167&rft_id=info:doi/10.1111/jce.16147&rft_dat=%3Cproquest_cross%3E2922241937%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2922241937&rft_id=info:pmid/38073051&rfr_iscdi=true