Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level

The type and strength of effector functions mediated by immunoglobulin G (IgG) antibodies rely on the subclass and the composition of the N297 glycan. Glycosylation analysis of both bulk and antigen-specific human IgG has revealed a marked diversity of the glycosylation signatures, including highly...

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Veröffentlicht in:	Immunology 2024-03, Vol.171 (3), p.428-439
Hauptverfasser:	de Graaf, Erik L, Larsen, Mads Delbo, van der Bolt, Nieke, Visser, Remco, Verhagen, Onno J H M, Hipgrave Ederveen, Agnes L, Koeleman, Carolien A M, van der Schoot, C Ellen, Wuhrer, Manfred, Vidarsson, Gestur
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Cell culture Culture Dynamic stability Glycan Glycosylation IgG antibody Immunoglobulin G Immunological memory Lymphocytes B Memory cells Variable region
Online-Zugang:	Volltext
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