Effects of antipsychotic drugs on energy metabolism

Schizophrenia (SCZ) is a complex neuropsychiatric disorder associated with altered bioenergetic pathways and mitochondrial dysfunction. Antipsychotic medications, both first and second-generation, are commonly prescribed to manage SCZ symptoms, but their direct impact on mitochondrial function remai...

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Veröffentlicht in:	European archives of psychiatry and clinical neuroscience 2024-08, Vol.274 (5), p.1125-1135
Hauptverfasser:	Panizzutti, Bruna, Bortolasci, Chiara C., Spolding, Briana, Kidnapillai, Srisaiyini, Connor, Timothy, Martin, Sheree D., Truong, Trang T. T., Liu, Zoe S. J., Gray, Laura, Kowalski, Greg M., McGee, Sean L., Kim, Jee Hyun, Berk, Michael, Walder, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Amisulpride - pharmacology Animals Antipsychotic Agents - pharmacology Antipsychotics Aripiprazole Aripiprazole - pharmacology Bioenergetics Cells, Cultured Clozapine Clozapine - pharmacology Drug metabolism Energy metabolism Energy Metabolism - drug effects Enzymatic activity Gas chromatography Gene expression Gene Expression - drug effects Glycolysis Mass spectroscopy Medicine Medicine & Public Health Mental disorders Metabolism Metabolites Metabolomics Mitochondria Mitochondria - drug effects Mitochondria - metabolism Neurons - drug effects Neurons - metabolism Neurosciences Original Paper Oxidative phosphorylation Phosphorylation Post-transcription Post-translation Psychiatry Psychotropic drugs Rats Risperidone Risperidone - pharmacology Schizophrenia Therapeutic applications Tricarboxylic acid cycle
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