Higher dietary acid load is associated with the risk of hyperuricemia
Purpose Dietary acid load plays a key role in regulating serum uric acid levels. We hypothesized that dietary acid load indices would be positively associated with the odds of hyperuricemia. We aimed to test this hypothesis in a representative sample of Iranian adult population. Methods In this cros...
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| Veröffentlicht in: | International urology and nephrology 2024-05, Vol.56 (5), p.1743-1749 |
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| creator | Seifi, Najmeh Bahari, Hossein Nosrati, Mina Koochakpoor, Glareh Alizadeh Hassani, Zahra Rastegarmoghadam-Ebrahimian, Arezoo Abedsaeidi, Malihehsadat Ferns, Gordon A. Ghyour-Mobarhan, Majid |
| description | Purpose
Dietary acid load plays a key role in regulating serum uric acid levels. We hypothesized that dietary acid load indices would be positively associated with the odds of hyperuricemia. We aimed to test this hypothesis in a representative sample of Iranian adult population.
Methods
In this cross-sectional study, a total of 6145 participants aged 35–65 years were recruited from MASHAD cohort study. Dietary intakes were assessed using a 24-h dietary recall. Diet-based acid load was assessed as the potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL). Hyperuricemia was defined as serum uric acid greater than the 75th percentile. Multivariable logistic regression models were applied to determine the association between diet-based acid load scores and hyperuricemia.
Results
The mean age of participants was 48.89 ± 8.09 years. Overall, 25.7% had hyperuricemia. According to the full-adjusted model, there was a significant association between higher tertile of PRAL, and DAL and hyperuricemia (Q3 PRAL; OR (95% CI): 1.23 (1.05–1.43), Q3 DAL; OR (95% CI): 1.22 (1.05–1.42)). Regarding NEAP, there was no significant association with hyperuricemia. We also found that dietary intake of total sugars, fiber, calcium, and magnesium was associated with the odds of hyperuricemia in our population.
Conclusion
This study showed a significant positive association between two indicators of dietary acid load (PRAL, and DAL) and odds of hyperuricemia among Iranian adults. |
| doi_str_mv | 10.1007/s11255-023-03876-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2902937949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3034564787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-c42f01d41fa53b3cb24f60db93c77c9091484bfaf9d3a4d3d7053141c49dfc4c3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlb_gAcJePGyOvnYJjlKqVYoeNFzyOajTW27NdlF-u9dbf3Ag6cZmGfeGR6EzglcEwBxkwmhZVkAZQUwKYaFPEB9UgpW0FLyw199D53kvAAAJQGOUY9JEFQq2UfjSZzNfcIu-sakLTY2OrysjcMxY5NzbaNpvMNvsZnjZu5xivkF1wHPtxuf2hStX0Vzio6CWWZ_tq8D9Hw3fhpNiunj_cPodlpYJsqmsJwGII6TYEpWMVtRHobgKsWsEFaBIlzyKpigHDPcMSegZIQTy5ULlls2QFe73E2qX1ufG72K2frl0qx93WZNFVDFhOKqQy__oIu6TevuO82A8XLIhRQdRXeUTXXOyQe9SXHVidAE9IdkvZOsO8n6U7KW3dLFPrqtVt59r3xZ7QC2A3I3Ws98-rn9T-w7LDKGbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3034564787</pqid></control><display><type>article</type><title>Higher dietary acid load is associated with the risk of hyperuricemia</title><source>SpringerNature Journals</source><creator>Seifi, Najmeh ; Bahari, Hossein ; Nosrati, Mina ; Koochakpoor, Glareh ; Alizadeh Hassani, Zahra ; Rastegarmoghadam-Ebrahimian, Arezoo ; Abedsaeidi, Malihehsadat ; Ferns, Gordon A. ; Ghyour-Mobarhan, Majid</creator><creatorcontrib>Seifi, Najmeh ; Bahari, Hossein ; Nosrati, Mina ; Koochakpoor, Glareh ; Alizadeh Hassani, Zahra ; Rastegarmoghadam-Ebrahimian, Arezoo ; Abedsaeidi, Malihehsadat ; Ferns, Gordon A. ; Ghyour-Mobarhan, Majid</creatorcontrib><description>Purpose
Dietary acid load plays a key role in regulating serum uric acid levels. We hypothesized that dietary acid load indices would be positively associated with the odds of hyperuricemia. We aimed to test this hypothesis in a representative sample of Iranian adult population.
Methods
In this cross-sectional study, a total of 6145 participants aged 35–65 years were recruited from MASHAD cohort study. Dietary intakes were assessed using a 24-h dietary recall. Diet-based acid load was assessed as the potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL). Hyperuricemia was defined as serum uric acid greater than the 75th percentile. Multivariable logistic regression models were applied to determine the association between diet-based acid load scores and hyperuricemia.
Results
The mean age of participants was 48.89 ± 8.09 years. Overall, 25.7% had hyperuricemia. According to the full-adjusted model, there was a significant association between higher tertile of PRAL, and DAL and hyperuricemia (Q3 PRAL; OR (95% CI): 1.23 (1.05–1.43), Q3 DAL; OR (95% CI): 1.22 (1.05–1.42)). Regarding NEAP, there was no significant association with hyperuricemia. We also found that dietary intake of total sugars, fiber, calcium, and magnesium was associated with the odds of hyperuricemia in our population.
Conclusion
This study showed a significant positive association between two indicators of dietary acid load (PRAL, and DAL) and odds of hyperuricemia among Iranian adults.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-023-03876-8</identifier><identifier>PMID: 38072898</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acid production ; Dietary intake ; Hyperuricemia ; Magnesium ; Medicine ; Medicine & Public Health ; Nephrology ; Nephrology - Original Paper ; Population studies ; Regression analysis ; Uric acid ; Urology</subject><ispartof>International urology and nephrology, 2024-05, Vol.56 (5), p.1743-1749</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-c42f01d41fa53b3cb24f60db93c77c9091484bfaf9d3a4d3d7053141c49dfc4c3</citedby><cites>FETCH-LOGICAL-c375t-c42f01d41fa53b3cb24f60db93c77c9091484bfaf9d3a4d3d7053141c49dfc4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-023-03876-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-023-03876-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38072898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seifi, Najmeh</creatorcontrib><creatorcontrib>Bahari, Hossein</creatorcontrib><creatorcontrib>Nosrati, Mina</creatorcontrib><creatorcontrib>Koochakpoor, Glareh</creatorcontrib><creatorcontrib>Alizadeh Hassani, Zahra</creatorcontrib><creatorcontrib>Rastegarmoghadam-Ebrahimian, Arezoo</creatorcontrib><creatorcontrib>Abedsaeidi, Malihehsadat</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Ghyour-Mobarhan, Majid</creatorcontrib><title>Higher dietary acid load is associated with the risk of hyperuricemia</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Purpose
Dietary acid load plays a key role in regulating serum uric acid levels. We hypothesized that dietary acid load indices would be positively associated with the odds of hyperuricemia. We aimed to test this hypothesis in a representative sample of Iranian adult population.
Methods
In this cross-sectional study, a total of 6145 participants aged 35–65 years were recruited from MASHAD cohort study. Dietary intakes were assessed using a 24-h dietary recall. Diet-based acid load was assessed as the potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL). Hyperuricemia was defined as serum uric acid greater than the 75th percentile. Multivariable logistic regression models were applied to determine the association between diet-based acid load scores and hyperuricemia.
Results
The mean age of participants was 48.89 ± 8.09 years. Overall, 25.7% had hyperuricemia. According to the full-adjusted model, there was a significant association between higher tertile of PRAL, and DAL and hyperuricemia (Q3 PRAL; OR (95% CI): 1.23 (1.05–1.43), Q3 DAL; OR (95% CI): 1.22 (1.05–1.42)). Regarding NEAP, there was no significant association with hyperuricemia. We also found that dietary intake of total sugars, fiber, calcium, and magnesium was associated with the odds of hyperuricemia in our population.
Conclusion
This study showed a significant positive association between two indicators of dietary acid load (PRAL, and DAL) and odds of hyperuricemia among Iranian adults.</description><subject>Acid production</subject><subject>Dietary intake</subject><subject>Hyperuricemia</subject><subject>Magnesium</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Uric acid</subject><subject>Urology</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMotlb_gAcJePGyOvnYJjlKqVYoeNFzyOajTW27NdlF-u9dbf3Ag6cZmGfeGR6EzglcEwBxkwmhZVkAZQUwKYaFPEB9UgpW0FLyw199D53kvAAAJQGOUY9JEFQq2UfjSZzNfcIu-sakLTY2OrysjcMxY5NzbaNpvMNvsZnjZu5xivkF1wHPtxuf2hStX0Vzio6CWWZ_tq8D9Hw3fhpNiunj_cPodlpYJsqmsJwGII6TYEpWMVtRHobgKsWsEFaBIlzyKpigHDPcMSegZIQTy5ULlls2QFe73E2qX1ufG72K2frl0qx93WZNFVDFhOKqQy__oIu6TevuO82A8XLIhRQdRXeUTXXOyQe9SXHVidAE9IdkvZOsO8n6U7KW3dLFPrqtVt59r3xZ7QC2A3I3Ws98-rn9T-w7LDKGbQ</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Seifi, Najmeh</creator><creator>Bahari, Hossein</creator><creator>Nosrati, Mina</creator><creator>Koochakpoor, Glareh</creator><creator>Alizadeh Hassani, Zahra</creator><creator>Rastegarmoghadam-Ebrahimian, Arezoo</creator><creator>Abedsaeidi, Malihehsadat</creator><creator>Ferns, Gordon A.</creator><creator>Ghyour-Mobarhan, Majid</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240501</creationdate><title>Higher dietary acid load is associated with the risk of hyperuricemia</title><author>Seifi, Najmeh ; Bahari, Hossein ; Nosrati, Mina ; Koochakpoor, Glareh ; Alizadeh Hassani, Zahra ; Rastegarmoghadam-Ebrahimian, Arezoo ; Abedsaeidi, Malihehsadat ; Ferns, Gordon A. ; Ghyour-Mobarhan, Majid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-c42f01d41fa53b3cb24f60db93c77c9091484bfaf9d3a4d3d7053141c49dfc4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acid production</topic><topic>Dietary intake</topic><topic>Hyperuricemia</topic><topic>Magnesium</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Uric acid</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seifi, Najmeh</creatorcontrib><creatorcontrib>Bahari, Hossein</creatorcontrib><creatorcontrib>Nosrati, Mina</creatorcontrib><creatorcontrib>Koochakpoor, Glareh</creatorcontrib><creatorcontrib>Alizadeh Hassani, Zahra</creatorcontrib><creatorcontrib>Rastegarmoghadam-Ebrahimian, Arezoo</creatorcontrib><creatorcontrib>Abedsaeidi, Malihehsadat</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Ghyour-Mobarhan, Majid</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seifi, Najmeh</au><au>Bahari, Hossein</au><au>Nosrati, Mina</au><au>Koochakpoor, Glareh</au><au>Alizadeh Hassani, Zahra</au><au>Rastegarmoghadam-Ebrahimian, Arezoo</au><au>Abedsaeidi, Malihehsadat</au><au>Ferns, Gordon A.</au><au>Ghyour-Mobarhan, Majid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher dietary acid load is associated with the risk of hyperuricemia</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>56</volume><issue>5</issue><spage>1743</spage><epage>1749</epage><pages>1743-1749</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Purpose
Dietary acid load plays a key role in regulating serum uric acid levels. We hypothesized that dietary acid load indices would be positively associated with the odds of hyperuricemia. We aimed to test this hypothesis in a representative sample of Iranian adult population.
Methods
In this cross-sectional study, a total of 6145 participants aged 35–65 years were recruited from MASHAD cohort study. Dietary intakes were assessed using a 24-h dietary recall. Diet-based acid load was assessed as the potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL). Hyperuricemia was defined as serum uric acid greater than the 75th percentile. Multivariable logistic regression models were applied to determine the association between diet-based acid load scores and hyperuricemia.
Results
The mean age of participants was 48.89 ± 8.09 years. Overall, 25.7% had hyperuricemia. According to the full-adjusted model, there was a significant association between higher tertile of PRAL, and DAL and hyperuricemia (Q3 PRAL; OR (95% CI): 1.23 (1.05–1.43), Q3 DAL; OR (95% CI): 1.22 (1.05–1.42)). Regarding NEAP, there was no significant association with hyperuricemia. We also found that dietary intake of total sugars, fiber, calcium, and magnesium was associated with the odds of hyperuricemia in our population.
Conclusion
This study showed a significant positive association between two indicators of dietary acid load (PRAL, and DAL) and odds of hyperuricemia among Iranian adults.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38072898</pmid><doi>10.1007/s11255-023-03876-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Acid production Dietary intake Hyperuricemia Magnesium Medicine Medicine & Public Health Nephrology Nephrology - Original Paper Population studies Regression analysis Uric acid Urology |
| title | Higher dietary acid load is associated with the risk of hyperuricemia |
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