A Bimetallic Polymerization Network for Effective Increase in Labile Iron Pool and Robust Activation of cGAS/STING Induces Ferroptosis‐Based Tumor Immunotherapy

Due to the inherent low immunogenicity and immunosuppressive tumor microenvironment (TME) of malignant cancers, the clinical efficacy and application of tumor immunotherapy have been limited. Herein, a bimetallic drug‐gene co‐loading network (Cu/ZIF‐8@U‐104@siNFS1‐HA) is developed that increased the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-05, Vol.20 (20), p.e2308397-n/a
Hauptverfasser:	Wang, Zhenxin, Zhou, Peng, Li, Yuting, Zhang, Dazhen, Chu, Fuchao, Yuan, Feng, Pan, Bin, Gao, Fenglei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bimetals Cancer carbon anhydrase IX Carbonic anhydrase Cell death Cell Line, Tumor cysteine desulfurase Depletion Enzyme activity Ferroptosis Ferroptosis - drug effects Glutathione Humans immunogenic cell death Immunotherapy Iron Iron - chemistry Iron - metabolism labile iron pool Lipid Peroxidation Lipids Membrane Proteins - metabolism Mice Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Nucleotidyltransferases - metabolism Peroxidase Polymerization Reactive Oxygen Species - metabolism Tumor Microenvironment Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!