A 3D-Printed Cuttlefish Bone Elastomeric Sponge Rapidly Controlling Noncompressible Hemorrhage
Developing a self-expanding hemostatic sponge with high blood absorption and rapid shape recovery for noncompressible hemorrhage remains a challenge. In this study, a 3D-printed cuttlefish bone elastomeric sponge (CBES) is fabricated, which combined ordered channels and porous structures, presented...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-05, Vol.20 (19), p.e2307041-e2307041 |
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| container_issue | 19 |
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| container_title | Small (Weinheim an der Bergstrasse, Germany) |
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| creator | Zhang, Xinchi Wang, Xuqiao Yuan, Pingping Ma, Chaoqun Wang, Yujiao Zhang, Zheqian Wang, Pengyu Zhao, Yimin Wu, Wei |
| description | Developing a self-expanding hemostatic sponge with high blood absorption and rapid shape recovery for noncompressible hemorrhage remains a challenge. In this study, a 3D-printed cuttlefish bone elastomeric sponge (CBES) is fabricated, which combined ordered channels and porous structures, presented tunable mechanical strength, and shape memory potentials. The incorporation of cuttlefish bone powder (CBp) plays key roles in concentrating blood components, promoting aggregation of red blood cells and platelets, and activating platelets, which makes CBES show enhanced hemostatic performance compared with commercial gelatin sponges in vivo. Moreover, CBES promotes more histiocytic infiltration and neovascularization in the early stage of degradation than gelatin sponges, which is conducive to the regeneration and repair of injured tissue. To conclude, CBp loaded 3D-printed elastomeric sponges can promote coagulation, present the potential to guide tissue healing, and broaden the hemostatic application of traditional Chinese medicine. |
| doi_str_mv | 10.1002/smll.202307041 |
| format | Article |
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In this study, a 3D-printed cuttlefish bone elastomeric sponge (CBES) is fabricated, which combined ordered channels and porous structures, presented tunable mechanical strength, and shape memory potentials. The incorporation of cuttlefish bone powder (CBp) plays key roles in concentrating blood components, promoting aggregation of red blood cells and platelets, and activating platelets, which makes CBES show enhanced hemostatic performance compared with commercial gelatin sponges in vivo. Moreover, CBES promotes more histiocytic infiltration and neovascularization in the early stage of degradation than gelatin sponges, which is conducive to the regeneration and repair of injured tissue. To conclude, CBp loaded 3D-printed elastomeric sponges can promote coagulation, present the potential to guide tissue healing, and broaden the hemostatic application of traditional Chinese medicine.</description><identifier>ISSN: 1613-6810</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.202307041</identifier><identifier>PMID: 38072798</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Coagulation ; Elastomers ; Erythrocytes ; Gelatin ; Hemorrhage ; Platelets ; Shape memory ; Sponges ; Three dimensional printing ; Traditional Chinese medicine</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2024-05, Vol.20 (19), p.e2307041-e2307041</ispartof><rights>2023 Wiley-VCH GmbH.</rights><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-3feb53227348d25a56739a177886cbd0b71455cd93a2593b7b828db868a3af963</citedby><cites>FETCH-LOGICAL-c323t-3feb53227348d25a56739a177886cbd0b71455cd93a2593b7b828db868a3af963</cites><orcidid>0000-0003-1570-0010 ; 0000-0003-1775-0388</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38072798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xinchi</creatorcontrib><creatorcontrib>Wang, Xuqiao</creatorcontrib><creatorcontrib>Yuan, Pingping</creatorcontrib><creatorcontrib>Ma, Chaoqun</creatorcontrib><creatorcontrib>Wang, Yujiao</creatorcontrib><creatorcontrib>Zhang, Zheqian</creatorcontrib><creatorcontrib>Wang, Pengyu</creatorcontrib><creatorcontrib>Zhao, Yimin</creatorcontrib><creatorcontrib>Wu, Wei</creatorcontrib><title>A 3D-Printed Cuttlefish Bone Elastomeric Sponge Rapidly Controlling Noncompressible Hemorrhage</title><title>Small (Weinheim an der Bergstrasse, Germany)</title><addtitle>Small</addtitle><description>Developing a self-expanding hemostatic sponge with high blood absorption and rapid shape recovery for noncompressible hemorrhage remains a challenge. In this study, a 3D-printed cuttlefish bone elastomeric sponge (CBES) is fabricated, which combined ordered channels and porous structures, presented tunable mechanical strength, and shape memory potentials. The incorporation of cuttlefish bone powder (CBp) plays key roles in concentrating blood components, promoting aggregation of red blood cells and platelets, and activating platelets, which makes CBES show enhanced hemostatic performance compared with commercial gelatin sponges in vivo. Moreover, CBES promotes more histiocytic infiltration and neovascularization in the early stage of degradation than gelatin sponges, which is conducive to the regeneration and repair of injured tissue. To conclude, CBp loaded 3D-printed elastomeric sponges can promote coagulation, present the potential to guide tissue healing, and broaden the hemostatic application of traditional Chinese medicine.</description><subject>Coagulation</subject><subject>Elastomers</subject><subject>Erythrocytes</subject><subject>Gelatin</subject><subject>Hemorrhage</subject><subject>Platelets</subject><subject>Shape memory</subject><subject>Sponges</subject><subject>Three dimensional printing</subject><subject>Traditional Chinese medicine</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkD1PwzAURS0EolBYGZElFpYU2y-OnbGEQpEqQHysRE7itKmcONjJ0H9PqpYOTPcN511dHYSuKJlQQtidr42ZMMKACBLSI3RGIwpBJFl8fLgpGaFz79eEAGWhOEUjkEQwEcsz9D3F8BC8uarpdIGTvuuMLiu_wve20XhmlO9srV2V44_WNkuN31VbFWaDE9t0zhpTNUv8Ypvc1q3T3leZ0Xiua-vcSi31BToplfH6cp9j9PU4-0zmweL16TmZLoIcGHQBlDrjwJiAUBaMKx4JiBUVQsoozwqSCRpynhcxKMZjyEQmmSwyGUkFqowjGKPbXW_r7E-vfZfWlc-1MarRtvcpiwmLQchB1Bjd_EPXtnfNsC4FwllEBq18oCY7KnfWe6fLtHVVrdwmpSTdmk-35tOD-eHhel_bZ7UuDvifavgFVEF97Q</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Zhang, Xinchi</creator><creator>Wang, Xuqiao</creator><creator>Yuan, Pingping</creator><creator>Ma, Chaoqun</creator><creator>Wang, Yujiao</creator><creator>Zhang, Zheqian</creator><creator>Wang, Pengyu</creator><creator>Zhao, Yimin</creator><creator>Wu, Wei</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1570-0010</orcidid><orcidid>https://orcid.org/0000-0003-1775-0388</orcidid></search><sort><creationdate>20240501</creationdate><title>A 3D-Printed Cuttlefish Bone Elastomeric Sponge Rapidly Controlling Noncompressible Hemorrhage</title><author>Zhang, Xinchi ; Wang, Xuqiao ; Yuan, Pingping ; Ma, Chaoqun ; Wang, Yujiao ; Zhang, Zheqian ; Wang, Pengyu ; Zhao, Yimin ; Wu, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-3feb53227348d25a56739a177886cbd0b71455cd93a2593b7b828db868a3af963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Coagulation</topic><topic>Elastomers</topic><topic>Erythrocytes</topic><topic>Gelatin</topic><topic>Hemorrhage</topic><topic>Platelets</topic><topic>Shape memory</topic><topic>Sponges</topic><topic>Three dimensional printing</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xinchi</creatorcontrib><creatorcontrib>Wang, Xuqiao</creatorcontrib><creatorcontrib>Yuan, Pingping</creatorcontrib><creatorcontrib>Ma, Chaoqun</creatorcontrib><creatorcontrib>Wang, Yujiao</creatorcontrib><creatorcontrib>Zhang, Zheqian</creatorcontrib><creatorcontrib>Wang, Pengyu</creatorcontrib><creatorcontrib>Zhao, Yimin</creatorcontrib><creatorcontrib>Wu, Wei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xinchi</au><au>Wang, Xuqiao</au><au>Yuan, Pingping</au><au>Ma, Chaoqun</au><au>Wang, Yujiao</au><au>Zhang, Zheqian</au><au>Wang, Pengyu</au><au>Zhao, Yimin</au><au>Wu, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 3D-Printed Cuttlefish Bone Elastomeric Sponge Rapidly Controlling Noncompressible Hemorrhage</atitle><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle><addtitle>Small</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>20</volume><issue>19</issue><spage>e2307041</spage><epage>e2307041</epage><pages>e2307041-e2307041</pages><issn>1613-6810</issn><eissn>1613-6829</eissn><abstract>Developing a self-expanding hemostatic sponge with high blood absorption and rapid shape recovery for noncompressible hemorrhage remains a challenge. In this study, a 3D-printed cuttlefish bone elastomeric sponge (CBES) is fabricated, which combined ordered channels and porous structures, presented tunable mechanical strength, and shape memory potentials. The incorporation of cuttlefish bone powder (CBp) plays key roles in concentrating blood components, promoting aggregation of red blood cells and platelets, and activating platelets, which makes CBES show enhanced hemostatic performance compared with commercial gelatin sponges in vivo. Moreover, CBES promotes more histiocytic infiltration and neovascularization in the early stage of degradation than gelatin sponges, which is conducive to the regeneration and repair of injured tissue. To conclude, CBp loaded 3D-printed elastomeric sponges can promote coagulation, present the potential to guide tissue healing, and broaden the hemostatic application of traditional Chinese medicine.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38072798</pmid><doi>10.1002/smll.202307041</doi><orcidid>https://orcid.org/0000-0003-1570-0010</orcidid><orcidid>https://orcid.org/0000-0003-1775-0388</orcidid></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | Coagulation Elastomers Erythrocytes Gelatin Hemorrhage Platelets Shape memory Sponges Three dimensional printing Traditional Chinese medicine |
| title | A 3D-Printed Cuttlefish Bone Elastomeric Sponge Rapidly Controlling Noncompressible Hemorrhage |
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