Impact of Pregnancy on the Pharmacokinetics and Metabolism of Nicotinamide in Humans

In pre‐eclampsia models, nicotinamide (NAM) has protective effects in pre‐eclampsia and is being evaluated as a therapeutic nutraceutical in clinical studies. NAM undergoes extensive hepatic metabolism by NAM N‐methyltransferase to methylnicotinamide (MNA), which is subsequently metabolized to methy...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2024-03, Vol.115 (3), p.556-564
Hauptverfasser:	Fashe, Muluneh M., Le, Tien V., Gower, Megan N., Mulrenin, Ian R., Dorman, Karen F., Smith, Spenser, Fallon, John K., Dumond, Julie B., Boggess, Kim A., Lee, Craig R.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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