Antidiabetic Effect of a New Original NT-3 Dipeptide Mimetic

It was previously established that the original dipeptide mimetic of the 4th loop of NT-3, hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301), has a pronounced neuroprotective effect in vitro at concentrations of 10 –5 –10 –12 М. In the present study, experiments on the s...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2023-10, Vol.512 (1), p.241-244
Hauptverfasser:	Yagubova, S. S., Chernyshevskaya, M. A., Ostrovskaya, R. U., Gudasheva, T. A., Seredenin, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiabetics Asparagine Beta cells Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Dipeptides - pharmacology Hyperglycemia Life Sciences Mice Molecular Biology Neurons Neuroprotection Neuroprotective Agents - pharmacology Neurotrophin 3 Peptidomimetics - pharmacology Polydipsia Streptozocin
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