Quantitative Evaluation of Blood Damage in a Centrifugal VAD by Computational Fluid Dynamics
This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device (LVAD) due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and e...
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| Veröffentlicht in: | Journal of fluids engineering 2004-05, Vol.126 (3), p.410-418 |
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| container_title | Journal of fluids engineering |
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| creator | Song, Xinwei Throckmorton, Amy L Wood, Houston G Antaki, James F Olsen, Don B |
| description | This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device (LVAD) due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated along the streaklines to evaluate the levels of blood trauma. This analysis, which includes viscous and turbulent stresses, provides a statistical estimate of possible damage to cells flowing through the pump. Since experimental data for hemolysis levels in our LVAD are not available, in vitro normalized index of hemolysis values for clinically available ventricular assist devices were compared to our damage indices. This approach allowed for an order of magnitude comparison between our estimations and experimentally measured hemolysis levels, which resulted in a reasonable correlation. This work ultimately demonstrates that CFD is a convenient and effective approach to analyze the Lagrangian behavior of blood in a heart assist device. |
| doi_str_mv | 10.1115/1.1758259 |
| format | Article |
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Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated along the streaklines to evaluate the levels of blood trauma. This analysis, which includes viscous and turbulent stresses, provides a statistical estimate of possible damage to cells flowing through the pump. Since experimental data for hemolysis levels in our LVAD are not available, in vitro normalized index of hemolysis values for clinically available ventricular assist devices were compared to our damage indices. This approach allowed for an order of magnitude comparison between our estimations and experimentally measured hemolysis levels, which resulted in a reasonable correlation. This work ultimately demonstrates that CFD is a convenient and effective approach to analyze the Lagrangian behavior of blood in a heart assist device.</description><identifier>ISSN: 0098-2202</identifier><identifier>EISSN: 1528-901X</identifier><identifier>DOI: 10.1115/1.1758259</identifier><identifier>CODEN: JFEGA4</identifier><language>eng</language><publisher>New York, NY: ASME</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Computational methods in fluid dynamics ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. 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Fluids Eng</addtitle><description>This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device (LVAD) due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated along the streaklines to evaluate the levels of blood trauma. This analysis, which includes viscous and turbulent stresses, provides a statistical estimate of possible damage to cells flowing through the pump. Since experimental data for hemolysis levels in our LVAD are not available, in vitro normalized index of hemolysis values for clinically available ventricular assist devices were compared to our damage indices. This approach allowed for an order of magnitude comparison between our estimations and experimentally measured hemolysis levels, which resulted in a reasonable correlation. This work ultimately demonstrates that CFD is a convenient and effective approach to analyze the Lagrangian behavior of blood in a heart assist device.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Computational methods in fluid dynamics</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Exact sciences and technology</subject><subject>Fluid dynamics</subject><subject>Fundamental areas of phenomenology (including applications)</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Physics</subject><issn>0098-2202</issn><issn>1528-901X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkMFLwzAUh4MoOKcHz15yUfDQmaRJ0xxnt6kwEEHFgxCeWTIy2mY27WD_vZ0bePTy3uPx_d6DD6FLSkaUUnFHR1SKnAl1hAZUsDxRhH4cowEhKk8YI-wUncW4IoSmKc8H6POlg7r1LbR-Y_F0A2XXj6HGweH7MoQFnkAFS4t9jQEXtm4b77ollPh9PMFfW1yEat21v5l-OSs730e2NVTexHN04qCM9uLQh-htNn0tHpP588NTMZ4nwDlvk5RzUAqEAWK4lMaIdOGszSlTmcitE8ZKkJyAk1IpZw0TkILNFGGS5dykQ3Szv7tuwndnY6srH40tS6ht6KJmvQQhWPY_mKdC8b4O0e0eNE2IsbFOrxtfQbPVlOidaE31QXTPXh-OQjRQugZq4-NfIOtdE7F7frXnIFZWr0LX9Mai5oJSKdMff5eFRA</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Song, Xinwei</creator><creator>Throckmorton, Amy L</creator><creator>Wood, Houston G</creator><creator>Antaki, James F</creator><creator>Olsen, Don B</creator><general>ASME</general><general>American Society of Mechanical Engineers</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SC</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>H8D</scope></search><sort><creationdate>20040501</creationdate><title>Quantitative Evaluation of Blood Damage in a Centrifugal VAD by Computational Fluid Dynamics</title><author>Song, Xinwei ; Throckmorton, Amy L ; Wood, Houston G ; Antaki, James F ; Olsen, Don B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a444t-344a99a5ca0c477cc53dfee8129658ef5ce7a740af7799fec25a3ae69027284c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Computational methods in fluid dynamics</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Exact sciences and technology</topic><topic>Fluid dynamics</topic><topic>Fundamental areas of phenomenology (including applications)</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Physics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Xinwei</creatorcontrib><creatorcontrib>Throckmorton, Amy L</creatorcontrib><creatorcontrib>Wood, Houston G</creatorcontrib><creatorcontrib>Antaki, James F</creatorcontrib><creatorcontrib>Olsen, Don B</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Computer and Information Systems Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Aerospace Database</collection><jtitle>Journal of fluids engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Xinwei</au><au>Throckmorton, Amy L</au><au>Wood, Houston G</au><au>Antaki, James F</au><au>Olsen, Don B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Evaluation of Blood Damage in a Centrifugal VAD by Computational Fluid Dynamics</atitle><jtitle>Journal of fluids engineering</jtitle><stitle>J. Fluids Eng</stitle><date>2004-05-01</date><risdate>2004</risdate><volume>126</volume><issue>3</issue><spage>410</spage><epage>418</epage><pages>410-418</pages><issn>0098-2202</issn><eissn>1528-901X</eissn><coden>JFEGA4</coden><abstract>This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device (LVAD) due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated along the streaklines to evaluate the levels of blood trauma. This analysis, which includes viscous and turbulent stresses, provides a statistical estimate of possible damage to cells flowing through the pump. Since experimental data for hemolysis levels in our LVAD are not available, in vitro normalized index of hemolysis values for clinically available ventricular assist devices were compared to our damage indices. 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| ispartof | Journal of fluids engineering, 2004-05, Vol.126 (3), p.410-418 |
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| language | eng |
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| source | ASME Transactions Journals (Current) |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Computational methods in fluid dynamics Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Exact sciences and technology Fluid dynamics Fundamental areas of phenomenology (including applications) Intensive care medicine Medical sciences Physics |
| title | Quantitative Evaluation of Blood Damage in a Centrifugal VAD by Computational Fluid Dynamics |
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