Design, synthesis, and biological evaluation of 2-amino-6-methyl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities

The suppression of ferroptosis is emerging as a promising therapeutic strategy for effectively treating a wide range of diseases, including neurodegenerative disorders, organ ischemia-reperfusion injury, and inflammatory conditions. However, the clinical utility of ferroptosis inhibitors is signific...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-01, Vol.264, p.115997-115997, Article 115997
Hauptverfasser:	Sheng, Xie-Huang, Han, Li-Cong, Ma, Xiao-Jie, Gong, Ao, Hao, Meng-Zhu, Zhu, Hao, Meng, Xiang-Shuai, Wang, Ting, Sun, Chang-Hua, Ma, Jian-Ping, Zhang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Lipid Peroxidation Lipid Peroxides - metabolism Mice Phenols - pharmacology Reactive Oxygen Species - metabolism Reperfusion Injury - drug therapy
Online-Zugang:	Volltext
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