Foamy macrophages are proinflammatory and express TREM2 in eruptive xanthomas

The accumulation of dermal foam cells (lipid-laden macrophages) is the primary histopathological feature of eruptive xanthomas. Yet, an understanding of the activation and implications of foamy macrophages in eruptive xanthomas remains unknown. We investigated foamy macrophage activation and found t...

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Veröffentlicht in:Clinical and experimental dermatology 2024-04, Vol.49 (5), p.507-510
Hauptverfasser: Huang, Yan, Dou, Hanyu, Cui, Baiping, Bai, Yun, Wang, Juan, Du, Qian, Lai, Yongxian, Liu, Yeqiang, Ding, Xiaolei
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Sprache:eng
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Zusammenfassung:The accumulation of dermal foam cells (lipid-laden macrophages) is the primary histopathological feature of eruptive xanthomas. Yet, an understanding of the activation and implications of foamy macrophages in eruptive xanthomas remains unknown. We investigated foamy macrophage activation and found that these cells are proinflammatory. Of note, foam cells in eruptive xanthomas express TREM2, a recently identified marker for lipid-laden macrophages in atherosclerosis and obesity.
ISSN:0307-6938
1365-2230
1365-2230
DOI:10.1093/ced/llad431