Heterobifunctional Cross-Linker with Dinitroimidazole and N‑Hydroxysuccinimide Ester Motifs for Protein Functionalization and Cysteine–Lysine Peptide Stapling

A heterobifunctional cross-linker with one sulfhydryl-reactive dinitroimidazole end and another amine-reactive N-hydroxysuccinimide (NHS) ester end was designed and synthesized. The two motifs of this cross-linker, dinitroimidazole and NHS ester, proved to react with thiol and amine, respectively, i...

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Veröffentlicht in:	Organic letters 2023-12, Vol.25 (49), p.8792-8796
Hauptverfasser:	Hua, Yaoguang, Liu, Shuli, Xie, Sai-Sai, Shi, Linjing, Li, Juncheng, Luo, Qunfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Cross-Linking Reagents Cysteine Lysine Peptides Proteins Sulfhydryl Compounds
Online-Zugang:	Volltext
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