NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis

Subcellular location and activation of Tank Binding Kinase 1 (TBK1) govern precise progression through mitosis. Either loss of activated TBK1 or its sequestration from the centrosomes causes errors in mitosis and growth defects. Yet, what regulates its recruitment and activation on the centrosomes i...

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Veröffentlicht in:	The Journal of cell biology 2024-02, Vol.223 (2), p.1
Hauptverfasser:	Paul, Swagatika, Sarraf, Shireen A, Nam, Ki Hong, Zavar, Leila, DeFoor, Nicole, Biswas, Sahitya Ranjan, Fritsch, Lauren E, Yaron, Tomer M, Johnson, Jared L, Huntsman, Emily M, Cantley, Lewis C, Ordureau, Alban, Pickrell, Alicia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Binding Cell Cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell division Centrosomes Cytokinesis Defects Humans Inactivation Kinases Microtubules Mitosis Proteasomes Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteins Substrates Ubiquitin
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