Transporters involved in adult rat cortical astrocyte dopamine uptake: Kinetics, expression and pharmacological modulation

Astrocytes, glial cells in the central nervous system, perform a multitude of homeostatic functions and are in constant bidirectional communication with neuronal cells, a concept named the tripartite synapse; however, their role in the dopamine homeostasis remains unexplored. The aim of this study w...

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Veröffentlicht in:	The European journal of neuroscience 2024-03, Vol.59 (6), p.1296-1310
Hauptverfasser:	Sočan, Vesna, Dolinar, Klemen, Kržan, Mojca
Format:	Artikel
Sprache:	eng
Schlagworte:	adult rat Animals Antidepressants Apomorphine Astrocytes Astrocytes - metabolism Cell interactions Central nervous system cortical astrocytes Desipramine Dopamine Dopamine - metabolism Dopamine Agents - metabolism Dopamine Agents - pharmacology Dopamine D1 receptors Dopamine D2 receptors Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter dopamine uptake Down-regulation Gene expression Glial cells Haloperidol Homeostasis Levodopa Monoamine transporter NET Norepinephrine Norepinephrine Plasma Membrane Transport Proteins - metabolism Norepinephrine transporter PMAT Rats Receptors, Dopamine - metabolism RNA, Messenger - metabolism Tricyclic antidepressants
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