Charge Conversional Biomimetic Nanosystem for Synergistic Photodynamic/Protein Therapy
Cytochrome C (Cytc) has received considerable attention due to its ability to induce tumor apoptosis and generate oxygen to improve photodynamic therapy (PDT) efficiency. However, the damage to normal tissues caused by nonspecific accumulation of Cytc limits its application. Herein, in order to redu...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-05, Vol.20 (19), p.e2307193-e2307193 |
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| creator | Ai, Shulun Zhao, Peisen Fang, Kaixuan Cheng, Hemei Cheng, Sixue Liu, Zhihong Wang, Caixia |
| description | Cytochrome C (Cytc) has received considerable attention due to its ability to induce tumor apoptosis and generate oxygen to improve photodynamic therapy (PDT) efficiency. However, the damage to normal tissues caused by nonspecific accumulation of Cytc limits its application. Herein, in order to reduce its toxicity to normal tissues while retaining its activity, a charge conversional biomimetic nanosystem (CA/Ce6@MSN-4T1) is proposed to improve the tumor targeting ability and realize controlled release of Cytc in the tumor microenvironment. This nanosystem is constructed by coating tumor cell membrane on mesoporous silica nanoparticles coloaded with a photosensitizer (chlorin e6, Ce6) and the citraconic anhydride conjugated Cytc (CA) for synergistic photodynamic/protein therapy. The coating of the tumor cell membrane endows the nanoparticles with homologous targeting ability to the same cancer cells as well as immune escaping capability. CA undergoes charge conversion in the acidic environment of the tumor to achieve a controlled release of Cytc. The released Cytc can relieve cellular hypoxia to improve the PDT efficiency of Ce6 and can induce programmed cell death. Both in vitro and in vivo studies demonstrated that CA/Ce6@MSN-4T1 can efficiently inhibit the growth of tumors through synergistic photodynamic/protein therapy, and meanwhile show reduced side effects on normal tissues. |
| doi_str_mv | 10.1002/smll.202307193 |
| format | Article |
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However, the damage to normal tissues caused by nonspecific accumulation of Cytc limits its application. Herein, in order to reduce its toxicity to normal tissues while retaining its activity, a charge conversional biomimetic nanosystem (CA/Ce6@MSN-4T1) is proposed to improve the tumor targeting ability and realize controlled release of Cytc in the tumor microenvironment. This nanosystem is constructed by coating tumor cell membrane on mesoporous silica nanoparticles coloaded with a photosensitizer (chlorin e6, Ce6) and the citraconic anhydride conjugated Cytc (CA) for synergistic photodynamic/protein therapy. The coating of the tumor cell membrane endows the nanoparticles with homologous targeting ability to the same cancer cells as well as immune escaping capability. CA undergoes charge conversion in the acidic environment of the tumor to achieve a controlled release of Cytc. The released Cytc can relieve cellular hypoxia to improve the PDT efficiency of Ce6 and can induce programmed cell death. Both in vitro and in vivo studies demonstrated that CA/Ce6@MSN-4T1 can efficiently inhibit the growth of tumors through synergistic photodynamic/protein therapy, and meanwhile show reduced side effects on normal tissues.</description><identifier>ISSN: 1613-6810</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.202307193</identifier><identifier>PMID: 38054765</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Apoptosis - drug effects ; Biocompatibility ; Biomimetic Materials - chemistry ; Biomimetic Materials - pharmacology ; Biomimetics ; Biomimetics - methods ; Cell death ; Cell Line, Tumor ; Cell membranes ; Chlorophyllides ; Controlled release ; Cytochromes c - metabolism ; Damage accumulation ; Humans ; In vivo methods and tests ; Mice ; Nanoparticles ; Nanoparticles - chemistry ; Photochemotherapy - methods ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacology ; Porphyrins - chemistry ; Porphyrins - pharmacology ; Proteins ; Side effects ; Silicon Dioxide - chemistry ; Tumors</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2024-05, Vol.20 (19), p.e2307193-e2307193</ispartof><rights>2023 Wiley‐VCH GmbH.</rights><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-e090a07821880c65b217cb5d36a8ab9e475984c3c72d8ab92d28781dfc5e3c633</citedby><cites>FETCH-LOGICAL-c323t-e090a07821880c65b217cb5d36a8ab9e475984c3c72d8ab92d28781dfc5e3c633</cites><orcidid>0009-0003-5377-4018</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38054765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ai, Shulun</creatorcontrib><creatorcontrib>Zhao, Peisen</creatorcontrib><creatorcontrib>Fang, Kaixuan</creatorcontrib><creatorcontrib>Cheng, Hemei</creatorcontrib><creatorcontrib>Cheng, Sixue</creatorcontrib><creatorcontrib>Liu, Zhihong</creatorcontrib><creatorcontrib>Wang, Caixia</creatorcontrib><title>Charge Conversional Biomimetic Nanosystem for Synergistic Photodynamic/Protein Therapy</title><title>Small (Weinheim an der Bergstrasse, Germany)</title><addtitle>Small</addtitle><description>Cytochrome C (Cytc) has received considerable attention due to its ability to induce tumor apoptosis and generate oxygen to improve photodynamic therapy (PDT) efficiency. However, the damage to normal tissues caused by nonspecific accumulation of Cytc limits its application. Herein, in order to reduce its toxicity to normal tissues while retaining its activity, a charge conversional biomimetic nanosystem (CA/Ce6@MSN-4T1) is proposed to improve the tumor targeting ability and realize controlled release of Cytc in the tumor microenvironment. This nanosystem is constructed by coating tumor cell membrane on mesoporous silica nanoparticles coloaded with a photosensitizer (chlorin e6, Ce6) and the citraconic anhydride conjugated Cytc (CA) for synergistic photodynamic/protein therapy. The coating of the tumor cell membrane endows the nanoparticles with homologous targeting ability to the same cancer cells as well as immune escaping capability. CA undergoes charge conversion in the acidic environment of the tumor to achieve a controlled release of Cytc. The released Cytc can relieve cellular hypoxia to improve the PDT efficiency of Ce6 and can induce programmed cell death. Both in vitro and in vivo studies demonstrated that CA/Ce6@MSN-4T1 can efficiently inhibit the growth of tumors through synergistic photodynamic/protein therapy, and meanwhile show reduced side effects on normal tissues.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Biocompatibility</subject><subject>Biomimetic Materials - chemistry</subject><subject>Biomimetic Materials - pharmacology</subject><subject>Biomimetics</subject><subject>Biomimetics - methods</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Cell membranes</subject><subject>Chlorophyllides</subject><subject>Controlled release</subject><subject>Cytochromes c - metabolism</subject><subject>Damage accumulation</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Photochemotherapy - methods</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Porphyrins - chemistry</subject><subject>Porphyrins - pharmacology</subject><subject>Proteins</subject><subject>Side effects</subject><subject>Silicon Dioxide - chemistry</subject><subject>Tumors</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkD1PwzAQhi0EoqWwMqJILCxp_RHH9ggRX1IFlSiskeO4ras4LnaClH9PopYOTHe6e-6V7gHgGsEpghDPgq2qKYaYQIYEOQFjlCISpxyL02OP4AhchLCFkCCcsHMwIhzShKV0DL6yjfRrHWWu_tE-GFfLKnowzhqrG6OiN1m70IVG22jlfPTR1dqvTRhWi41rXNnV0ho1W3jXaFNHy432ctddgrOVrIK-OtQJ-Hx6XGYv8fz9-TW7n8eKYNLEGgooIeMYcQ5VSguMmCpoSVLJZSF0wqjgiSKK4XIY4BJzxlG5UlQTlRIyAXf73J13360OTW5NULqqZK1dG3LMBRc04UL06O0_dOta378bcgIppkKknPfUdE8p70LwepXvvLHSdzmC-WA8H4znR-P9wc0hti2sLo_4n2LyC4EafI4</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Ai, Shulun</creator><creator>Zhao, Peisen</creator><creator>Fang, Kaixuan</creator><creator>Cheng, Hemei</creator><creator>Cheng, Sixue</creator><creator>Liu, Zhihong</creator><creator>Wang, Caixia</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0003-5377-4018</orcidid></search><sort><creationdate>20240501</creationdate><title>Charge Conversional Biomimetic Nanosystem for Synergistic Photodynamic/Protein Therapy</title><author>Ai, Shulun ; Zhao, Peisen ; Fang, Kaixuan ; Cheng, Hemei ; Cheng, Sixue ; Liu, Zhihong ; Wang, Caixia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-e090a07821880c65b217cb5d36a8ab9e475984c3c72d8ab92d28781dfc5e3c633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Biocompatibility</topic><topic>Biomimetic Materials - chemistry</topic><topic>Biomimetic Materials - pharmacology</topic><topic>Biomimetics</topic><topic>Biomimetics - methods</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Cell membranes</topic><topic>Chlorophyllides</topic><topic>Controlled release</topic><topic>Cytochromes c - metabolism</topic><topic>Damage accumulation</topic><topic>Humans</topic><topic>In vivo methods and tests</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Porphyrins - chemistry</topic><topic>Porphyrins - pharmacology</topic><topic>Proteins</topic><topic>Side effects</topic><topic>Silicon Dioxide - chemistry</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ai, Shulun</creatorcontrib><creatorcontrib>Zhao, Peisen</creatorcontrib><creatorcontrib>Fang, Kaixuan</creatorcontrib><creatorcontrib>Cheng, Hemei</creatorcontrib><creatorcontrib>Cheng, Sixue</creatorcontrib><creatorcontrib>Liu, Zhihong</creatorcontrib><creatorcontrib>Wang, Caixia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ai, Shulun</au><au>Zhao, Peisen</au><au>Fang, Kaixuan</au><au>Cheng, Hemei</au><au>Cheng, Sixue</au><au>Liu, Zhihong</au><au>Wang, Caixia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Charge Conversional Biomimetic Nanosystem for Synergistic Photodynamic/Protein Therapy</atitle><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle><addtitle>Small</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>20</volume><issue>19</issue><spage>e2307193</spage><epage>e2307193</epage><pages>e2307193-e2307193</pages><issn>1613-6810</issn><eissn>1613-6829</eissn><abstract>Cytochrome C (Cytc) has received considerable attention due to its ability to induce tumor apoptosis and generate oxygen to improve photodynamic therapy (PDT) efficiency. However, the damage to normal tissues caused by nonspecific accumulation of Cytc limits its application. Herein, in order to reduce its toxicity to normal tissues while retaining its activity, a charge conversional biomimetic nanosystem (CA/Ce6@MSN-4T1) is proposed to improve the tumor targeting ability and realize controlled release of Cytc in the tumor microenvironment. This nanosystem is constructed by coating tumor cell membrane on mesoporous silica nanoparticles coloaded with a photosensitizer (chlorin e6, Ce6) and the citraconic anhydride conjugated Cytc (CA) for synergistic photodynamic/protein therapy. The coating of the tumor cell membrane endows the nanoparticles with homologous targeting ability to the same cancer cells as well as immune escaping capability. CA undergoes charge conversion in the acidic environment of the tumor to achieve a controlled release of Cytc. The released Cytc can relieve cellular hypoxia to improve the PDT efficiency of Ce6 and can induce programmed cell death. Both in vitro and in vivo studies demonstrated that CA/Ce6@MSN-4T1 can efficiently inhibit the growth of tumors through synergistic photodynamic/protein therapy, and meanwhile show reduced side effects on normal tissues.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38054765</pmid><doi>10.1002/smll.202307193</doi><orcidid>https://orcid.org/0009-0003-5377-4018</orcidid></addata></record> |
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| subjects | Animals Apoptosis - drug effects Biocompatibility Biomimetic Materials - chemistry Biomimetic Materials - pharmacology Biomimetics Biomimetics - methods Cell death Cell Line, Tumor Cell membranes Chlorophyllides Controlled release Cytochromes c - metabolism Damage accumulation Humans In vivo methods and tests Mice Nanoparticles Nanoparticles - chemistry Photochemotherapy - methods Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Porphyrins - chemistry Porphyrins - pharmacology Proteins Side effects Silicon Dioxide - chemistry Tumors |
| title | Charge Conversional Biomimetic Nanosystem for Synergistic Photodynamic/Protein Therapy |
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