Gut microbial signatures in clinically stable ulcerative colitis according to the mucosal state and associated symptoms
Background and Aim The gut microbiome of patients with clinically stable ulcerative colitis (UC) differs from that of healthy individuals depending on the state of the colonic mucosa, especially with or without advanced scarring; however, the underlying mechanism is unclear. Therefore, this study ex...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2024-02, Vol.39 (2), p.319-327 |
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| creator | Kim, Soyoung Jung, Yeonjae Lee, Seung Bum Oh, Hyun‐Seok Hong, Sung Noh |
| description | Background and Aim
The gut microbiome of patients with clinically stable ulcerative colitis (UC) differs from that of healthy individuals depending on the state of the colonic mucosa, especially with or without advanced scarring; however, the underlying mechanism is unclear. Therefore, this study examined the gut microbiome compositional signatures in patients with significant mucosal scarring and UC‐related symptoms.
Methods
Stool samples for gut microbiome analysis were prospectively collected from 57 patients with clinically stable UC between January 1 and December 31, 2022. Data from 57 individuals without inflammatory bowel disease (non‐IBD) paired by age and sex were selected from our previous study as the control group. The fecal samples were subjected to 16S rRNA gene sequencing. Associations between gut microbiome profiles and clinical or colonoscopic assessments were examined using diversity and differential abundance analyses.
Results
Gut microbiome compositions between the patients with clinically stable UC and non‐IBD controls differed significantly. Furthermore, gut microbiome compositions varied between the preserved and altered mucosa groups identified based on mucosal changes in the UC group. Differential abundance test of patients with UC for symptomatic remission based on stool frequency from the two‐item patient‐reported outcome identified several overlapping taxa specified as gut microbiome signatures, including the Enterobacteriaceae unknown genera (Enterobacteriaceae_g), Klebsiella, and several Lachnospiraceae spp. both in mucosal and symptom change analyses.
Conclusions
The gut microbiome can change with mucosal changes, even in clinically stable UC, and some gut microbial signatures may explain the symptom manifestations in patients with UC showing significant mucosal changes.
The gut microbiome can change with mucosal changes, even in clinically stable UC, and some gut microbial signatures may explain the symptom manifestations in patients with UC showing significant mucosal changes |
| doi_str_mv | 10.1111/jgh.16434 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2898954533</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2898954533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3134-f78c971e225a186def89c6d16addd63d114fbb5595578ff17443a2db2a7920d83</originalsourceid><addsrcrecordid>eNp1kc2KFDEURoMoTju68AUk4EYXNZPfqmQpg_YoA250HVJJqidNqtLmphz67U3bowvBbC6Bw-He70PoNSVXtL3r_e7-ivaCiydoQ4UgHR1E_xRtiKKy05zqC_QCYE8IEWSQz9EFV0QKqcgGPWzXiufoSh6jTRjibrF1LQFwXLBLcYnOpnTEUO2YAl6TC8XW-DNgl1OsEbB1Lhcflx2uGdf7gOfVZTi5qq0B28VjC5BdbD-P4Tgfap7hJXo22QTh1eO8RN8_ffx2c9vdfd1-vvlw1zlOueimQTk90MCYtFT1PkxKu97T3nrve-4pFdM4SqmlHNQ0tbsFt8yPzA6aEa_4JXp39h5K_rEGqGaO4EJKdgl5BcOUVrplwXlD3_6D7vNalradYZq1tCgbTtT7M9UiAyhhMocSZ1uOhhJzasO0NszvNhr75tG4jnPwf8k_8Tfg-gw8xBSO_zeZL9vbs_IXW3mVIA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2925801273</pqid></control><display><type>article</type><title>Gut microbial signatures in clinically stable ulcerative colitis according to the mucosal state and associated symptoms</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kim, Soyoung ; Jung, Yeonjae ; Lee, Seung Bum ; Oh, Hyun‐Seok ; Hong, Sung Noh</creator><creatorcontrib>Kim, Soyoung ; Jung, Yeonjae ; Lee, Seung Bum ; Oh, Hyun‐Seok ; Hong, Sung Noh</creatorcontrib><description>Background and Aim
The gut microbiome of patients with clinically stable ulcerative colitis (UC) differs from that of healthy individuals depending on the state of the colonic mucosa, especially with or without advanced scarring; however, the underlying mechanism is unclear. Therefore, this study examined the gut microbiome compositional signatures in patients with significant mucosal scarring and UC‐related symptoms.
Methods
Stool samples for gut microbiome analysis were prospectively collected from 57 patients with clinically stable UC between January 1 and December 31, 2022. Data from 57 individuals without inflammatory bowel disease (non‐IBD) paired by age and sex were selected from our previous study as the control group. The fecal samples were subjected to 16S rRNA gene sequencing. Associations between gut microbiome profiles and clinical or colonoscopic assessments were examined using diversity and differential abundance analyses.
Results
Gut microbiome compositions between the patients with clinically stable UC and non‐IBD controls differed significantly. Furthermore, gut microbiome compositions varied between the preserved and altered mucosa groups identified based on mucosal changes in the UC group. Differential abundance test of patients with UC for symptomatic remission based on stool frequency from the two‐item patient‐reported outcome identified several overlapping taxa specified as gut microbiome signatures, including the Enterobacteriaceae unknown genera (Enterobacteriaceae_g), Klebsiella, and several Lachnospiraceae spp. both in mucosal and symptom change analyses.
Conclusions
The gut microbiome can change with mucosal changes, even in clinically stable UC, and some gut microbial signatures may explain the symptom manifestations in patients with UC showing significant mucosal changes.
The gut microbiome can change with mucosal changes, even in clinically stable UC, and some gut microbial signatures may explain the symptom manifestations in patients with UC showing significant mucosal changes</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.16434</identifier><identifier>PMID: 38054580</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>biomarker ; Enterobacteriaceae ; Feces ; gut microbiome ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Intestinal microflora ; Microbiomes ; Mucosa ; Remission ; rRNA 16S ; Ulcerative colitis</subject><ispartof>Journal of gastroenterology and hepatology, 2024-02, Vol.39 (2), p.319-327</ispartof><rights>2023 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2024 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3134-f78c971e225a186def89c6d16addd63d114fbb5595578ff17443a2db2a7920d83</cites><orcidid>0000-0001-7638-4977 ; 0000-0002-5880-5659 ; 0000-0002-4140-3717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.16434$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.16434$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38054580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Soyoung</creatorcontrib><creatorcontrib>Jung, Yeonjae</creatorcontrib><creatorcontrib>Lee, Seung Bum</creatorcontrib><creatorcontrib>Oh, Hyun‐Seok</creatorcontrib><creatorcontrib>Hong, Sung Noh</creatorcontrib><title>Gut microbial signatures in clinically stable ulcerative colitis according to the mucosal state and associated symptoms</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
The gut microbiome of patients with clinically stable ulcerative colitis (UC) differs from that of healthy individuals depending on the state of the colonic mucosa, especially with or without advanced scarring; however, the underlying mechanism is unclear. Therefore, this study examined the gut microbiome compositional signatures in patients with significant mucosal scarring and UC‐related symptoms.
Methods
Stool samples for gut microbiome analysis were prospectively collected from 57 patients with clinically stable UC between January 1 and December 31, 2022. Data from 57 individuals without inflammatory bowel disease (non‐IBD) paired by age and sex were selected from our previous study as the control group. The fecal samples were subjected to 16S rRNA gene sequencing. Associations between gut microbiome profiles and clinical or colonoscopic assessments were examined using diversity and differential abundance analyses.
Results
Gut microbiome compositions between the patients with clinically stable UC and non‐IBD controls differed significantly. Furthermore, gut microbiome compositions varied between the preserved and altered mucosa groups identified based on mucosal changes in the UC group. Differential abundance test of patients with UC for symptomatic remission based on stool frequency from the two‐item patient‐reported outcome identified several overlapping taxa specified as gut microbiome signatures, including the Enterobacteriaceae unknown genera (Enterobacteriaceae_g), Klebsiella, and several Lachnospiraceae spp. both in mucosal and symptom change analyses.
Conclusions
The gut microbiome can change with mucosal changes, even in clinically stable UC, and some gut microbial signatures may explain the symptom manifestations in patients with UC showing significant mucosal changes.
The gut microbiome can change with mucosal changes, even in clinically stable UC, and some gut microbial signatures may explain the symptom manifestations in patients with UC showing significant mucosal changes</description><subject>biomarker</subject><subject>Enterobacteriaceae</subject><subject>Feces</subject><subject>gut microbiome</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Intestinal microflora</subject><subject>Microbiomes</subject><subject>Mucosa</subject><subject>Remission</subject><subject>rRNA 16S</subject><subject>Ulcerative colitis</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kc2KFDEURoMoTju68AUk4EYXNZPfqmQpg_YoA250HVJJqidNqtLmphz67U3bowvBbC6Bw-He70PoNSVXtL3r_e7-ivaCiydoQ4UgHR1E_xRtiKKy05zqC_QCYE8IEWSQz9EFV0QKqcgGPWzXiufoSh6jTRjibrF1LQFwXLBLcYnOpnTEUO2YAl6TC8XW-DNgl1OsEbB1Lhcflx2uGdf7gOfVZTi5qq0B28VjC5BdbD-P4Tgfap7hJXo22QTh1eO8RN8_ffx2c9vdfd1-vvlw1zlOueimQTk90MCYtFT1PkxKu97T3nrve-4pFdM4SqmlHNQ0tbsFt8yPzA6aEa_4JXp39h5K_rEGqGaO4EJKdgl5BcOUVrplwXlD3_6D7vNalradYZq1tCgbTtT7M9UiAyhhMocSZ1uOhhJzasO0NszvNhr75tG4jnPwf8k_8Tfg-gw8xBSO_zeZL9vbs_IXW3mVIA</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Kim, Soyoung</creator><creator>Jung, Yeonjae</creator><creator>Lee, Seung Bum</creator><creator>Oh, Hyun‐Seok</creator><creator>Hong, Sung Noh</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7638-4977</orcidid><orcidid>https://orcid.org/0000-0002-5880-5659</orcidid><orcidid>https://orcid.org/0000-0002-4140-3717</orcidid></search><sort><creationdate>202402</creationdate><title>Gut microbial signatures in clinically stable ulcerative colitis according to the mucosal state and associated symptoms</title><author>Kim, Soyoung ; Jung, Yeonjae ; Lee, Seung Bum ; Oh, Hyun‐Seok ; Hong, Sung Noh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3134-f78c971e225a186def89c6d16addd63d114fbb5595578ff17443a2db2a7920d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>biomarker</topic><topic>Enterobacteriaceae</topic><topic>Feces</topic><topic>gut microbiome</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Intestinal microflora</topic><topic>Microbiomes</topic><topic>Mucosa</topic><topic>Remission</topic><topic>rRNA 16S</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Soyoung</creatorcontrib><creatorcontrib>Jung, Yeonjae</creatorcontrib><creatorcontrib>Lee, Seung Bum</creatorcontrib><creatorcontrib>Oh, Hyun‐Seok</creatorcontrib><creatorcontrib>Hong, Sung Noh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Soyoung</au><au>Jung, Yeonjae</au><au>Lee, Seung Bum</au><au>Oh, Hyun‐Seok</au><au>Hong, Sung Noh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbial signatures in clinically stable ulcerative colitis according to the mucosal state and associated symptoms</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2024-02</date><risdate>2024</risdate><volume>39</volume><issue>2</issue><spage>319</spage><epage>327</epage><pages>319-327</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
The gut microbiome of patients with clinically stable ulcerative colitis (UC) differs from that of healthy individuals depending on the state of the colonic mucosa, especially with or without advanced scarring; however, the underlying mechanism is unclear. Therefore, this study examined the gut microbiome compositional signatures in patients with significant mucosal scarring and UC‐related symptoms.
Methods
Stool samples for gut microbiome analysis were prospectively collected from 57 patients with clinically stable UC between January 1 and December 31, 2022. Data from 57 individuals without inflammatory bowel disease (non‐IBD) paired by age and sex were selected from our previous study as the control group. The fecal samples were subjected to 16S rRNA gene sequencing. Associations between gut microbiome profiles and clinical or colonoscopic assessments were examined using diversity and differential abundance analyses.
Results
Gut microbiome compositions between the patients with clinically stable UC and non‐IBD controls differed significantly. Furthermore, gut microbiome compositions varied between the preserved and altered mucosa groups identified based on mucosal changes in the UC group. Differential abundance test of patients with UC for symptomatic remission based on stool frequency from the two‐item patient‐reported outcome identified several overlapping taxa specified as gut microbiome signatures, including the Enterobacteriaceae unknown genera (Enterobacteriaceae_g), Klebsiella, and several Lachnospiraceae spp. both in mucosal and symptom change analyses.
Conclusions
The gut microbiome can change with mucosal changes, even in clinically stable UC, and some gut microbial signatures may explain the symptom manifestations in patients with UC showing significant mucosal changes.
The gut microbiome can change with mucosal changes, even in clinically stable UC, and some gut microbial signatures may explain the symptom manifestations in patients with UC showing significant mucosal changes</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38054580</pmid><doi>10.1111/jgh.16434</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7638-4977</orcidid><orcidid>https://orcid.org/0000-0002-5880-5659</orcidid><orcidid>https://orcid.org/0000-0002-4140-3717</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | biomarker Enterobacteriaceae Feces gut microbiome Inflammatory bowel disease Inflammatory bowel diseases Intestinal microflora Microbiomes Mucosa Remission rRNA 16S Ulcerative colitis |
| title | Gut microbial signatures in clinically stable ulcerative colitis according to the mucosal state and associated symptoms |
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