Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1
Objective This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites. Methods A total of 525 adult male Sprague Dawley rats were randomized to lateral fluid percussion‐induced...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2024-02, Vol.65 (2), p.511-526 |
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| creator | Ndode‐Ekane, Xavier Ekolle Ali, Idrish Santana‐Gomez, Cesar Andrade, Pedro Immonen, Riikka Casillas‐Espinosa, Pablo Paananen, Tomi Manninen, Eppu Puhakka, Noora Smith, Gregory Brady, Rhys D. Silva, Juliana Braine, Emma Hudson, Matt Yamakawa, Glen R. Jones, Nigel C. Shultz, Sandy R. Harris, Neil Wright, David K. Gröhn, Olli Staba, Richard O'Brien, Terence J. Pitkänen, Asla |
| description | Objective
This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites.
Methods
A total of 525 adult male Sprague Dawley rats were randomized to lateral fluid percussion‐induced brain injury (FPI) or sham operation. Of these, 264 were assigned to magnetic resonance imaging (MRI cohort, 43 sham, 221 traumatic brain injury [TBI]) and 261 to electrophysiological follow‐up (EEG cohort, 41 sham, 220 TBI). A major effort was made to harmonize the rats, materials, equipment, procedures, and monitoring systems. On the 7th post‐TBI month, rats were video‐EEG monitored for epilepsy diagnosis.
Results
A total of 245 rats were video‐EEG phenotyped for epilepsy on the 7th postinjury month (121 in MRI cohort, 124 in EEG cohort). In the whole cohort (n = 245), the prevalence of PTE in rats with TBI was 22%, being 27% in the MRI and 18% in the EEG cohort (p > .05). Prevalence of PTE did not differ between the three study sites (p > .05). The average seizure frequency was .317 ± .725 seizures/day at University of Eastern Finland (UEF; Finland), .085 ± .067 at Monash University (Monash; Australia), and .299 ± .266 at University of California, Los Angeles (UCLA; USA; p .05). Of the 219 seizures, 53% occurred as part of a seizure cluster (≥3 seizures/24 h; p >.05 between the study sites). Of the 209 seizures, 56% occurred during lights‐on period and 44% during lights‐off period (p > .05 between the study sites).
Significance
The PTE phenotype induced by lateral FPI is reproducible in a multicenter design. Our study supports the feasibility of performing preclinical multicenter trials in PTE to increase statistical power and experimental rigor to produce clinically translatable data to combat epileptogenesis after TBI. |
| doi_str_mv | 10.1111/epi.17838 |
| format | Article |
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This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites.
Methods
A total of 525 adult male Sprague Dawley rats were randomized to lateral fluid percussion‐induced brain injury (FPI) or sham operation. Of these, 264 were assigned to magnetic resonance imaging (MRI cohort, 43 sham, 221 traumatic brain injury [TBI]) and 261 to electrophysiological follow‐up (EEG cohort, 41 sham, 220 TBI). A major effort was made to harmonize the rats, materials, equipment, procedures, and monitoring systems. On the 7th post‐TBI month, rats were video‐EEG monitored for epilepsy diagnosis.
Results
A total of 245 rats were video‐EEG phenotyped for epilepsy on the 7th postinjury month (121 in MRI cohort, 124 in EEG cohort). In the whole cohort (n = 245), the prevalence of PTE in rats with TBI was 22%, being 27% in the MRI and 18% in the EEG cohort (p > .05). Prevalence of PTE did not differ between the three study sites (p > .05). The average seizure frequency was .317 ± .725 seizures/day at University of Eastern Finland (UEF; Finland), .085 ± .067 at Monash University (Monash; Australia), and .299 ± .266 at University of California, Los Angeles (UCLA; USA; p < .01 as compared to Monash). The average seizure duration did not differ between UEF (104 ± 48 s), Monash (90 ± 33 s), and UCLA (105 ± 473 s; p > .05). Of the 219 seizures, 53% occurred as part of a seizure cluster (≥3 seizures/24 h; p >.05 between the study sites). Of the 209 seizures, 56% occurred during lights‐on period and 44% during lights‐off period (p > .05 between the study sites).
Significance
The PTE phenotype induced by lateral FPI is reproducible in a multicenter design. Our study supports the feasibility of performing preclinical multicenter trials in PTE to increase statistical power and experimental rigor to produce clinically translatable data to combat epileptogenesis after TBI.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/epi.17838</identifier><identifier>PMID: 38052475</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Brain Injuries, Traumatic - complications ; Brain Injuries, Traumatic - diagnostic imaging ; Convulsions & seizures ; Disease Models, Animal ; EEG ; Epilepsy ; Epilepsy - etiology ; Epilepsy, Post-Traumatic - etiology ; Epilepsy, Post-Traumatic - pathology ; Feasibility studies ; Genotype & phenotype ; harmonization ; Humans ; Magnetic resonance imaging ; Male ; Neuroimaging ; Percussion ; Phenotype ; Phenotypes ; posttraumatic epilepsy ; preclinical ; Rats ; Rats, Sprague-Dawley ; Reproducibility ; Reproducibility of Results ; Seizures ; Traumatic brain injury ; video‐EEG monitoring</subject><ispartof>Epilepsia (Copenhagen), 2024-02, Vol.65 (2), p.511-526</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.</rights><rights>2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3488-5e697cea8a5ff1c5bbd42bd245cba43ab76a4ea4b3d066644684bd1ae4a21c253</cites><orcidid>0000-0002-1080-8439 ; 0000-0002-8163-5416 ; 0000-0002-9353-6079 ; 0000-0002-1965-6750 ; 0000-0001-9163-5615 ; 0000-0001-5682-5632 ; 0000-0002-2146-4221 ; 0000-0002-0971-4654 ; 0000-0002-6199-9415</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fepi.17838$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fepi.17838$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38052475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ndode‐Ekane, Xavier Ekolle</creatorcontrib><creatorcontrib>Ali, Idrish</creatorcontrib><creatorcontrib>Santana‐Gomez, Cesar</creatorcontrib><creatorcontrib>Andrade, Pedro</creatorcontrib><creatorcontrib>Immonen, Riikka</creatorcontrib><creatorcontrib>Casillas‐Espinosa, Pablo</creatorcontrib><creatorcontrib>Paananen, Tomi</creatorcontrib><creatorcontrib>Manninen, Eppu</creatorcontrib><creatorcontrib>Puhakka, Noora</creatorcontrib><creatorcontrib>Smith, Gregory</creatorcontrib><creatorcontrib>Brady, Rhys D.</creatorcontrib><creatorcontrib>Silva, Juliana</creatorcontrib><creatorcontrib>Braine, Emma</creatorcontrib><creatorcontrib>Hudson, Matt</creatorcontrib><creatorcontrib>Yamakawa, Glen R.</creatorcontrib><creatorcontrib>Jones, Nigel C.</creatorcontrib><creatorcontrib>Shultz, Sandy R.</creatorcontrib><creatorcontrib>Harris, Neil</creatorcontrib><creatorcontrib>Wright, David K.</creatorcontrib><creatorcontrib>Gröhn, Olli</creatorcontrib><creatorcontrib>Staba, Richard</creatorcontrib><creatorcontrib>O'Brien, Terence J.</creatorcontrib><creatorcontrib>Pitkänen, Asla</creatorcontrib><title>Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Objective
This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites.
Methods
A total of 525 adult male Sprague Dawley rats were randomized to lateral fluid percussion‐induced brain injury (FPI) or sham operation. Of these, 264 were assigned to magnetic resonance imaging (MRI cohort, 43 sham, 221 traumatic brain injury [TBI]) and 261 to electrophysiological follow‐up (EEG cohort, 41 sham, 220 TBI). A major effort was made to harmonize the rats, materials, equipment, procedures, and monitoring systems. On the 7th post‐TBI month, rats were video‐EEG monitored for epilepsy diagnosis.
Results
A total of 245 rats were video‐EEG phenotyped for epilepsy on the 7th postinjury month (121 in MRI cohort, 124 in EEG cohort). In the whole cohort (n = 245), the prevalence of PTE in rats with TBI was 22%, being 27% in the MRI and 18% in the EEG cohort (p > .05). Prevalence of PTE did not differ between the three study sites (p > .05). The average seizure frequency was .317 ± .725 seizures/day at University of Eastern Finland (UEF; Finland), .085 ± .067 at Monash University (Monash; Australia), and .299 ± .266 at University of California, Los Angeles (UCLA; USA; p < .01 as compared to Monash). The average seizure duration did not differ between UEF (104 ± 48 s), Monash (90 ± 33 s), and UCLA (105 ± 473 s; p > .05). Of the 219 seizures, 53% occurred as part of a seizure cluster (≥3 seizures/24 h; p >.05 between the study sites). Of the 209 seizures, 56% occurred during lights‐on period and 44% during lights‐off period (p > .05 between the study sites).
Significance
The PTE phenotype induced by lateral FPI is reproducible in a multicenter design. Our study supports the feasibility of performing preclinical multicenter trials in PTE to increase statistical power and experimental rigor to produce clinically translatable data to combat epileptogenesis after TBI.</description><subject>Animals</subject><subject>Brain Injuries, Traumatic - complications</subject><subject>Brain Injuries, Traumatic - diagnostic imaging</subject><subject>Convulsions & seizures</subject><subject>Disease Models, Animal</subject><subject>EEG</subject><subject>Epilepsy</subject><subject>Epilepsy - etiology</subject><subject>Epilepsy, Post-Traumatic - etiology</subject><subject>Epilepsy, Post-Traumatic - pathology</subject><subject>Feasibility studies</subject><subject>Genotype & phenotype</subject><subject>harmonization</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Neuroimaging</subject><subject>Percussion</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>posttraumatic epilepsy</subject><subject>preclinical</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproducibility</subject><subject>Reproducibility of Results</subject><subject>Seizures</subject><subject>Traumatic brain injury</subject><subject>video‐EEG monitoring</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kctu1TAQhi0EoofCghdAltjQRVo7thOHXakOUKkIxGUdje2J8FFOEnwRZNdHYM3j8SS4nMICiVnMLObTNyP9hDzm7JSXOsPFn_JWC32HbLiqdcV5094lG8a4qDql2RF5EOOOMdY2rbhPjoRmqpat2pAf28WPuMSVLp9xmtO6IIXJUZ8iDbiE2WXrjR99WikMCQMdoXQY6TBm7-iCweYY_Tz9vP7up0KjoylA3kPylpoAfqJ-2uWwlkEDpPicvsljWeJ0oyv3X_j5g3z_jcaUXfkjzDu0ifKH5N4AY8RHt_OYfHq5_Xjxurp6--ry4vyqskJqXSlsutYiaFDDwK0yxsnauFoqa0AKMG0DEkEa4VjTNFI2WhrHASXU3NZKHJNnB2-5_CVjTP3eR4vjCBPOOfa17nSnRMe6gj79B93NOUzlu77uikpzLmShTg6UDXOMAYd-CX4PYe05628C60tg_e_ACvvk1pjNHt1f8k9CBTg7AF9LTuv_Tf323eVB-QuZT6QG</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Ndode‐Ekane, Xavier Ekolle</creator><creator>Ali, Idrish</creator><creator>Santana‐Gomez, Cesar</creator><creator>Andrade, Pedro</creator><creator>Immonen, Riikka</creator><creator>Casillas‐Espinosa, Pablo</creator><creator>Paananen, Tomi</creator><creator>Manninen, Eppu</creator><creator>Puhakka, Noora</creator><creator>Smith, Gregory</creator><creator>Brady, Rhys D.</creator><creator>Silva, Juliana</creator><creator>Braine, Emma</creator><creator>Hudson, Matt</creator><creator>Yamakawa, Glen R.</creator><creator>Jones, Nigel C.</creator><creator>Shultz, Sandy R.</creator><creator>Harris, Neil</creator><creator>Wright, David K.</creator><creator>Gröhn, Olli</creator><creator>Staba, Richard</creator><creator>O'Brien, Terence J.</creator><creator>Pitkänen, Asla</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1080-8439</orcidid><orcidid>https://orcid.org/0000-0002-8163-5416</orcidid><orcidid>https://orcid.org/0000-0002-9353-6079</orcidid><orcidid>https://orcid.org/0000-0002-1965-6750</orcidid><orcidid>https://orcid.org/0000-0001-9163-5615</orcidid><orcidid>https://orcid.org/0000-0001-5682-5632</orcidid><orcidid>https://orcid.org/0000-0002-2146-4221</orcidid><orcidid>https://orcid.org/0000-0002-0971-4654</orcidid><orcidid>https://orcid.org/0000-0002-6199-9415</orcidid></search><sort><creationdate>202402</creationdate><title>Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1</title><author>Ndode‐Ekane, Xavier Ekolle ; Ali, Idrish ; Santana‐Gomez, Cesar ; Andrade, Pedro ; Immonen, Riikka ; Casillas‐Espinosa, Pablo ; Paananen, Tomi ; Manninen, Eppu ; Puhakka, Noora ; Smith, Gregory ; Brady, Rhys D. ; Silva, Juliana ; Braine, Emma ; Hudson, Matt ; Yamakawa, Glen R. ; Jones, Nigel C. ; Shultz, Sandy R. ; Harris, Neil ; Wright, David K. ; Gröhn, Olli ; Staba, Richard ; O'Brien, Terence J. ; Pitkänen, Asla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3488-5e697cea8a5ff1c5bbd42bd245cba43ab76a4ea4b3d066644684bd1ae4a21c253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Brain Injuries, Traumatic - complications</topic><topic>Brain Injuries, Traumatic - diagnostic imaging</topic><topic>Convulsions & seizures</topic><topic>Disease Models, Animal</topic><topic>EEG</topic><topic>Epilepsy</topic><topic>Epilepsy - etiology</topic><topic>Epilepsy, Post-Traumatic - etiology</topic><topic>Epilepsy, Post-Traumatic - pathology</topic><topic>Feasibility studies</topic><topic>Genotype & phenotype</topic><topic>harmonization</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Neuroimaging</topic><topic>Percussion</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>posttraumatic epilepsy</topic><topic>preclinical</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproducibility</topic><topic>Reproducibility of Results</topic><topic>Seizures</topic><topic>Traumatic brain injury</topic><topic>video‐EEG monitoring</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ndode‐Ekane, Xavier Ekolle</creatorcontrib><creatorcontrib>Ali, Idrish</creatorcontrib><creatorcontrib>Santana‐Gomez, Cesar</creatorcontrib><creatorcontrib>Andrade, Pedro</creatorcontrib><creatorcontrib>Immonen, Riikka</creatorcontrib><creatorcontrib>Casillas‐Espinosa, Pablo</creatorcontrib><creatorcontrib>Paananen, Tomi</creatorcontrib><creatorcontrib>Manninen, Eppu</creatorcontrib><creatorcontrib>Puhakka, Noora</creatorcontrib><creatorcontrib>Smith, Gregory</creatorcontrib><creatorcontrib>Brady, Rhys D.</creatorcontrib><creatorcontrib>Silva, Juliana</creatorcontrib><creatorcontrib>Braine, Emma</creatorcontrib><creatorcontrib>Hudson, Matt</creatorcontrib><creatorcontrib>Yamakawa, Glen R.</creatorcontrib><creatorcontrib>Jones, Nigel C.</creatorcontrib><creatorcontrib>Shultz, Sandy R.</creatorcontrib><creatorcontrib>Harris, Neil</creatorcontrib><creatorcontrib>Wright, David K.</creatorcontrib><creatorcontrib>Gröhn, Olli</creatorcontrib><creatorcontrib>Staba, Richard</creatorcontrib><creatorcontrib>O'Brien, Terence J.</creatorcontrib><creatorcontrib>Pitkänen, Asla</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ndode‐Ekane, Xavier Ekolle</au><au>Ali, Idrish</au><au>Santana‐Gomez, Cesar</au><au>Andrade, Pedro</au><au>Immonen, Riikka</au><au>Casillas‐Espinosa, Pablo</au><au>Paananen, Tomi</au><au>Manninen, Eppu</au><au>Puhakka, Noora</au><au>Smith, Gregory</au><au>Brady, Rhys D.</au><au>Silva, Juliana</au><au>Braine, Emma</au><au>Hudson, Matt</au><au>Yamakawa, Glen R.</au><au>Jones, Nigel C.</au><au>Shultz, Sandy R.</au><au>Harris, Neil</au><au>Wright, David K.</au><au>Gröhn, Olli</au><au>Staba, Richard</au><au>O'Brien, Terence J.</au><au>Pitkänen, Asla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2024-02</date><risdate>2024</risdate><volume>65</volume><issue>2</issue><spage>511</spage><epage>526</epage><pages>511-526</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><abstract>Objective
This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites.
Methods
A total of 525 adult male Sprague Dawley rats were randomized to lateral fluid percussion‐induced brain injury (FPI) or sham operation. Of these, 264 were assigned to magnetic resonance imaging (MRI cohort, 43 sham, 221 traumatic brain injury [TBI]) and 261 to electrophysiological follow‐up (EEG cohort, 41 sham, 220 TBI). A major effort was made to harmonize the rats, materials, equipment, procedures, and monitoring systems. On the 7th post‐TBI month, rats were video‐EEG monitored for epilepsy diagnosis.
Results
A total of 245 rats were video‐EEG phenotyped for epilepsy on the 7th postinjury month (121 in MRI cohort, 124 in EEG cohort). In the whole cohort (n = 245), the prevalence of PTE in rats with TBI was 22%, being 27% in the MRI and 18% in the EEG cohort (p > .05). Prevalence of PTE did not differ between the three study sites (p > .05). The average seizure frequency was .317 ± .725 seizures/day at University of Eastern Finland (UEF; Finland), .085 ± .067 at Monash University (Monash; Australia), and .299 ± .266 at University of California, Los Angeles (UCLA; USA; p < .01 as compared to Monash). The average seizure duration did not differ between UEF (104 ± 48 s), Monash (90 ± 33 s), and UCLA (105 ± 473 s; p > .05). Of the 219 seizures, 53% occurred as part of a seizure cluster (≥3 seizures/24 h; p >.05 between the study sites). Of the 209 seizures, 56% occurred during lights‐on period and 44% during lights‐off period (p > .05 between the study sites).
Significance
The PTE phenotype induced by lateral FPI is reproducible in a multicenter design. Our study supports the feasibility of performing preclinical multicenter trials in PTE to increase statistical power and experimental rigor to produce clinically translatable data to combat epileptogenesis after TBI.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38052475</pmid><doi>10.1111/epi.17838</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-1080-8439</orcidid><orcidid>https://orcid.org/0000-0002-8163-5416</orcidid><orcidid>https://orcid.org/0000-0002-9353-6079</orcidid><orcidid>https://orcid.org/0000-0002-1965-6750</orcidid><orcidid>https://orcid.org/0000-0001-9163-5615</orcidid><orcidid>https://orcid.org/0000-0001-5682-5632</orcidid><orcidid>https://orcid.org/0000-0002-2146-4221</orcidid><orcidid>https://orcid.org/0000-0002-0971-4654</orcidid><orcidid>https://orcid.org/0000-0002-6199-9415</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-9580 |
| ispartof | Epilepsia (Copenhagen), 2024-02, Vol.65 (2), p.511-526 |
| issn | 0013-9580 1528-1167 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Brain Injuries, Traumatic - complications Brain Injuries, Traumatic - diagnostic imaging Convulsions & seizures Disease Models, Animal EEG Epilepsy Epilepsy - etiology Epilepsy, Post-Traumatic - etiology Epilepsy, Post-Traumatic - pathology Feasibility studies Genotype & phenotype harmonization Humans Magnetic resonance imaging Male Neuroimaging Percussion Phenotype Phenotypes posttraumatic epilepsy preclinical Rats Rats, Sprague-Dawley Reproducibility Reproducibility of Results Seizures Traumatic brain injury video‐EEG monitoring |
| title | Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1 |
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