Exploring Cell-Penetrating Peptides as Penetration Enhancers in Eye Drop Formulations Using a Reconstructed Human Corneal Epithelial Model

Ocular tissues function as biological barriers that hinder drug delivery, depending on the target tissue and route of administration, and must be overcome to achieve the desired therapeutic effect. Penetration enhancers have long been investigated to improve corneal drug penetration via eye drop ins...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2023/12/01, Vol.46(12), pp.1720-1730
Hauptverfasser:	Morofuji, Ryo, Enomoto, Hiroshi, Honda, Takahiro, Oyama, Yuki, Ishida, Reiji, Kudo, Kazuhiro, Okabe, Komei
Format:	Artikel
Sprache:	eng
Schlagworte:	cell-penetrating peptide Cornea corneal epithelium Drug delivery Eye eyedrop Irritation LabCyte CORNEA-MODEL24 Peptides Surface plasmon resonance
Online-Zugang:	Volltext
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