Role of Rho Kinase in Regulating Arterial Stiffness in Anesthetized Rabbits
The effects of Rho kinase inhibitors fasudil and ripasudil on arterial stiffness were assessed using anesthetized rabbits, where the aortic β and femoral β were measured as a stiffness parameter at each arterial region. Intravenous administration of fasudil and ripasudil dose-dependently decreased b...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2023/12/01, Vol.46(12), pp.1846-1850 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | Takahara, Akira Matsumoto, Manami Sato, Akira Inose, Shuto Aimoto, Megumi Nagasawa, Yoshinobu |
| description | The effects of Rho kinase inhibitors fasudil and ripasudil on arterial stiffness were assessed using anesthetized rabbits, where the aortic β and femoral β were measured as a stiffness parameter at each arterial region. Intravenous administration of fasudil and ripasudil dose-dependently decreased blood pressure and femoral vascular resistance and increased femoral arterial blood flow, which appeared according to their in vitro potencies for Rho kinase inhibition. Both drugs increased the aortic β but decreased the femoral β at hypotensive doses. These results suggest that the inhibition of Rho kinase contributes to reducing elastic recoil in the aorta and an increase in compliance in the femoral artery. In addition, the Rho kinase-associated Ca2+-independent mechanism of arterial vascular smooth muscle contraction may be essential in the regulation of femoral arterial stiffness. |
| doi_str_mv | 10.1248/bpb.b23-00591 |
| format | Article |
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Intravenous administration of fasudil and ripasudil dose-dependently decreased blood pressure and femoral vascular resistance and increased femoral arterial blood flow, which appeared according to their in vitro potencies for Rho kinase inhibition. Both drugs increased the aortic β but decreased the femoral β at hypotensive doses. These results suggest that the inhibition of Rho kinase contributes to reducing elastic recoil in the aorta and an increase in compliance in the femoral artery. In addition, the Rho kinase-associated Ca2+-independent mechanism of arterial vascular smooth muscle contraction may be essential in the regulation of femoral arterial stiffness.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b23-00591</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Aorta ; arterial stiffness ; Blood flow ; Blood pressure ; Femoral artery ; Femur ; Intravenous administration ; Muscle contraction ; Rho kinase inhibitor ; Rho-associated kinase ; Smooth muscle</subject><ispartof>Biological and Pharmaceutical Bulletin, 2023/12/01, Vol.46(12), pp.1846-1850</ispartof><rights>2023 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c477t-2c26ea7d9d258f73adbec35f916c9d5da9d8fce61ac0e9f4c233b0e68229d3b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27903,27904</link.rule.ids></links><search><creatorcontrib>Takahara, Akira</creatorcontrib><creatorcontrib>Matsumoto, Manami</creatorcontrib><creatorcontrib>Sato, Akira</creatorcontrib><creatorcontrib>Inose, Shuto</creatorcontrib><creatorcontrib>Aimoto, Megumi</creatorcontrib><creatorcontrib>Nagasawa, Yoshinobu</creatorcontrib><title>Role of Rho Kinase in Regulating Arterial Stiffness in Anesthetized Rabbits</title><title>Biological & pharmaceutical bulletin</title><description>The effects of Rho kinase inhibitors fasudil and ripasudil on arterial stiffness were assessed using anesthetized rabbits, where the aortic β and femoral β were measured as a stiffness parameter at each arterial region. Intravenous administration of fasudil and ripasudil dose-dependently decreased blood pressure and femoral vascular resistance and increased femoral arterial blood flow, which appeared according to their in vitro potencies for Rho kinase inhibition. Both drugs increased the aortic β but decreased the femoral β at hypotensive doses. These results suggest that the inhibition of Rho kinase contributes to reducing elastic recoil in the aorta and an increase in compliance in the femoral artery. In addition, the Rho kinase-associated Ca2+-independent mechanism of arterial vascular smooth muscle contraction may be essential in the regulation of femoral arterial stiffness.</description><subject>Aorta</subject><subject>arterial stiffness</subject><subject>Blood flow</subject><subject>Blood pressure</subject><subject>Femoral artery</subject><subject>Femur</subject><subject>Intravenous administration</subject><subject>Muscle contraction</subject><subject>Rho kinase inhibitor</subject><subject>Rho-associated kinase</subject><subject>Smooth muscle</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0DtPwzAQB3ALgUQpjOyRWFhS_MjDHiveaiWkALPl2OfWVZoU2xng05O0qAOLz9L97nT6I3RN8IzQjN_Vu3pWU5ZinAtygiaEZWWaU5KfogkWhKcFyfk5ughhgzEuMWUTtKi6BpLOJtW6SxauVQES1yYVrPpGRdeukrmP4J1qkvforG0hhBHMh09cQ3Q_YJJK1bWL4RKdWdUEuPqrU_T59Phx_5Iu355f7-fLVGdlGVOqaQGqNMLQnNuSKVODZrkVpNDC5EYJw62GgiiNQdhMU8ZqDAWnVBhW52yKbg97d7776oc75NYFDU2jWuj6ICkXZcY5L0d6849uut63w3WSCpIxQSmng0oPSvsuBA9W7rzbKv8tCZZjtHKIVg7Ryn20g384-E2IagVHrXx0uoG9zophcnyPY8e2XisvoWW_ncKEZA</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Takahara, Akira</creator><creator>Matsumoto, Manami</creator><creator>Sato, Akira</creator><creator>Inose, Shuto</creator><creator>Aimoto, Megumi</creator><creator>Nagasawa, Yoshinobu</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20231201</creationdate><title>Role of Rho Kinase in Regulating Arterial Stiffness in Anesthetized Rabbits</title><author>Takahara, Akira ; Matsumoto, Manami ; Sato, Akira ; Inose, Shuto ; Aimoto, Megumi ; Nagasawa, Yoshinobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-2c26ea7d9d258f73adbec35f916c9d5da9d8fce61ac0e9f4c233b0e68229d3b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aorta</topic><topic>arterial stiffness</topic><topic>Blood flow</topic><topic>Blood pressure</topic><topic>Femoral artery</topic><topic>Femur</topic><topic>Intravenous administration</topic><topic>Muscle contraction</topic><topic>Rho kinase inhibitor</topic><topic>Rho-associated kinase</topic><topic>Smooth muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahara, Akira</creatorcontrib><creatorcontrib>Matsumoto, Manami</creatorcontrib><creatorcontrib>Sato, Akira</creatorcontrib><creatorcontrib>Inose, Shuto</creatorcontrib><creatorcontrib>Aimoto, Megumi</creatorcontrib><creatorcontrib>Nagasawa, Yoshinobu</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahara, Akira</au><au>Matsumoto, Manami</au><au>Sato, Akira</au><au>Inose, Shuto</au><au>Aimoto, Megumi</au><au>Nagasawa, Yoshinobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Rho Kinase in Regulating Arterial Stiffness in Anesthetized Rabbits</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><date>2023-12-01</date><risdate>2023</risdate><volume>46</volume><issue>12</issue><spage>1846</spage><epage>1850</epage><pages>1846-1850</pages><artnum>b23-00591</artnum><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The effects of Rho kinase inhibitors fasudil and ripasudil on arterial stiffness were assessed using anesthetized rabbits, where the aortic β and femoral β were measured as a stiffness parameter at each arterial region. 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| source | J-STAGE Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Aorta arterial stiffness Blood flow Blood pressure Femoral artery Femur Intravenous administration Muscle contraction Rho kinase inhibitor Rho-associated kinase Smooth muscle |
| title | Role of Rho Kinase in Regulating Arterial Stiffness in Anesthetized Rabbits |
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