Discovery of 4-aminophenylacetamide derivatives as intestine-specific farnesoid X receptor antagonists for the potential treatment of nonalcoholic steatohepatitis

Farnesoid X receptor (FXR) plays a key role in bile acid homeostasis, inflammation, fibrosis, lipid and glucose metabolism and is emerging as a promising therapeutic target for nonalcoholic steatohepatitis (NASH). Emerging evidence suggested that intestine-specific FXR antagonists exhibited remarkab...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-01, Vol.264, p.115992-115992, Article 115992
Hauptverfasser:	Chen, Cong, Zhang, Bing, Tu, Jiaojiao, Peng, Yanfen, Zhou, Yihuan, Yang, Xinping, Yu, Qiming, Tan, Xiangduan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Inflammation Intestines Mice Non-alcoholic Fatty Liver Disease - drug therapy Receptors, Cytoplasmic and Nuclear
Online-Zugang:	Volltext
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