Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR
Background In 2021, an updated Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) without a coefficient for race (CKD-EPI21) was developed. The performance of this new equation has yet to be examined among specific patient groups. Met...
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| Veröffentlicht in: | Clinical kidney journal 2023-12, Vol.16 (12), p.2728-2737 |
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| creator | Munch, Philip Vestergaard Heide-Jørgensen, Uffe Jensen, Simon Kok Birn, Henrik Vestergaard, Søren Viborg Frøkiær, Jørgen Sørensen, Henrik Toft Christiansen, Christian Fynbo |
| description | Background
In 2021, an updated Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) without a coefficient for race (CKD-EPI21) was developed. The performance of this new equation has yet to be examined among specific patient groups.
Methods
We compared the performances of the new CKD-EPI21 equation and the 2009 equation assuming non-Black race (CKD-EPI09-NB) in patients with GFR measured by chromium-51-EDTA plasma clearance at Aarhus University Hospital in Denmark during 2010–18. We examined bias, accuracy, precision and correct classification of chronic kidney disease (CKD) stage using chromium-51-EDTA clearance as the reference standard. We assessed the performance in the total cohort, cancer patients and potential living kidney donors. We also assessed the performance stratified by CKD stage in the total cohort.
Results
In this predominantly white population, the CKD-EPI21 equation performed slightly better than the CKD-EPI09-NB equation in both the total cohort (N = 4668), and in cancer patients (N = 3313) and potential living kidney donors (N = 239). In the total cohort, the CKD-EPI21 equation demonstrated a slightly lower median absolute bias (−0.2 versus −4.4 mL/min/1.73 m2), and a similar accuracy, precision and correct classification of CKD stage compared with the CKD-EPI09-NB equation. When stratified by CKD stage, the CKD-EPI09-NB equation performed slightly better than the CKD-EPI21 equation among patients with a measured GFR (mGFR) |
| doi_str_mv | 10.1093/ckj/sfad253 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2897485201</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A776923318</galeid><oup_id>10.1093/ckj/sfad253</oup_id><sourcerecordid>A776923318</sourcerecordid><originalsourceid>FETCH-LOGICAL-c331t-db2cdb8ca69a887d8f9c7579f0844c9cbb7cef0cfb4cdce4c47656f01403acec3</originalsourceid><addsrcrecordid>eNp90V9LwzAQAPAiCo65J79AQBBBuqVtuqaPY39UHCiizyG9XmzmmmxJi_jtjUwEQUweEi6_Oy5cFJ0ndJzQMpvA22bilazTPDuKBillPOZ5kh3_3Gl-Go2839Cwwgtl-SBqHtEp61ppAIlVpGuQOAkYK4dI5veLePl4R8Ch7LTRBuNKeqwJ3qyeCO77ELWGaEMkWUijfUPANtZ15F13DWlR-t4FHvRZdKLk1uPo-xxGL6vl8_w2Xj_c3M1n6xiyLOniukqhrjjIaSk5L2quSijyolSUMwYlVFUBqCioikENyIAV03yqaMJoFtqGbBhdHerunN336DvRag-43UqDtvci5WXBeJ7SJNCLA32VWxTaKNuFr39xMSuKaZmGjnhQ4z9U2DW2GqxBpUP8V8L1IQGc9d6hEjunW-k-RELF16REmJT4nlTQlwdt-92_8BP0cpNH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2897485201</pqid></control><display><type>article</type><title>Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford Journals Open Access Collection</source><source>PubMed Central</source><creator>Munch, Philip Vestergaard ; Heide-Jørgensen, Uffe ; Jensen, Simon Kok ; Birn, Henrik ; Vestergaard, Søren Viborg ; Frøkiær, Jørgen ; Sørensen, Henrik Toft ; Christiansen, Christian Fynbo</creator><creatorcontrib>Munch, Philip Vestergaard ; Heide-Jørgensen, Uffe ; Jensen, Simon Kok ; Birn, Henrik ; Vestergaard, Søren Viborg ; Frøkiær, Jørgen ; Sørensen, Henrik Toft ; Christiansen, Christian Fynbo</creatorcontrib><description>Background
In 2021, an updated Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) without a coefficient for race (CKD-EPI21) was developed. The performance of this new equation has yet to be examined among specific patient groups.
Methods
We compared the performances of the new CKD-EPI21 equation and the 2009 equation assuming non-Black race (CKD-EPI09-NB) in patients with GFR measured by chromium-51-EDTA plasma clearance at Aarhus University Hospital in Denmark during 2010–18. We examined bias, accuracy, precision and correct classification of chronic kidney disease (CKD) stage using chromium-51-EDTA clearance as the reference standard. We assessed the performance in the total cohort, cancer patients and potential living kidney donors. We also assessed the performance stratified by CKD stage in the total cohort.
Results
In this predominantly white population, the CKD-EPI21 equation performed slightly better than the CKD-EPI09-NB equation in both the total cohort (N = 4668), and in cancer patients (N = 3313) and potential living kidney donors (N = 239). In the total cohort, the CKD-EPI21 equation demonstrated a slightly lower median absolute bias (−0.2 versus −4.4 mL/min/1.73 m2), and a similar accuracy, precision and correct classification of CKD stage compared with the CKD-EPI09-NB equation. When stratified by CKD stage, the CKD-EPI09-NB equation performed slightly better than the CKD-EPI21 equation among patients with a measured GFR (mGFR) <60 mL/min/1.73 m2.
Conclusions
In a selected cohort of Danish patients with mGFR, the CKD-EPI21 equation performed slightly better than the CKD-EPI09-NB equation except for patients with a mGFR <60 mL/min/1.73 m2, where CKD-EPI09-NB performed slightly better although the differences were considered clinically insignificant.</description><identifier>ISSN: 2048-8505</identifier><identifier>EISSN: 2048-8513</identifier><identifier>DOI: 10.1093/ckj/sfad253</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Chronic kidney failure ; Comparative analysis ; Epidemiology ; Ethylenediaminetetraacetic acid ; Medical care ; Quality management ; Transplantation of organs, tissues, etc</subject><ispartof>Clinical kidney journal, 2023-12, Vol.16 (12), p.2728-2737</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. 2023</rights><rights>COPYRIGHT 2023 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-db2cdb8ca69a887d8f9c7579f0844c9cbb7cef0cfb4cdce4c47656f01403acec3</citedby><cites>FETCH-LOGICAL-c331t-db2cdb8ca69a887d8f9c7579f0844c9cbb7cef0cfb4cdce4c47656f01403acec3</cites><orcidid>0000-0002-8407-4618 ; 0000-0002-0032-131X ; 0000-0002-6206-8065 ; 0000-0003-4299-7040 ; 0000-0002-8239-2970 ; 0000-0002-0727-953X ; 0000-0003-3715-7266 ; 0000-0002-8445-7758</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,862,1601,27907,27908</link.rule.ids></links><search><creatorcontrib>Munch, Philip Vestergaard</creatorcontrib><creatorcontrib>Heide-Jørgensen, Uffe</creatorcontrib><creatorcontrib>Jensen, Simon Kok</creatorcontrib><creatorcontrib>Birn, Henrik</creatorcontrib><creatorcontrib>Vestergaard, Søren Viborg</creatorcontrib><creatorcontrib>Frøkiær, Jørgen</creatorcontrib><creatorcontrib>Sørensen, Henrik Toft</creatorcontrib><creatorcontrib>Christiansen, Christian Fynbo</creatorcontrib><title>Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR</title><title>Clinical kidney journal</title><description>Background
In 2021, an updated Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) without a coefficient for race (CKD-EPI21) was developed. The performance of this new equation has yet to be examined among specific patient groups.
Methods
We compared the performances of the new CKD-EPI21 equation and the 2009 equation assuming non-Black race (CKD-EPI09-NB) in patients with GFR measured by chromium-51-EDTA plasma clearance at Aarhus University Hospital in Denmark during 2010–18. We examined bias, accuracy, precision and correct classification of chronic kidney disease (CKD) stage using chromium-51-EDTA clearance as the reference standard. We assessed the performance in the total cohort, cancer patients and potential living kidney donors. We also assessed the performance stratified by CKD stage in the total cohort.
Results
In this predominantly white population, the CKD-EPI21 equation performed slightly better than the CKD-EPI09-NB equation in both the total cohort (N = 4668), and in cancer patients (N = 3313) and potential living kidney donors (N = 239). In the total cohort, the CKD-EPI21 equation demonstrated a slightly lower median absolute bias (−0.2 versus −4.4 mL/min/1.73 m2), and a similar accuracy, precision and correct classification of CKD stage compared with the CKD-EPI09-NB equation. When stratified by CKD stage, the CKD-EPI09-NB equation performed slightly better than the CKD-EPI21 equation among patients with a measured GFR (mGFR) <60 mL/min/1.73 m2.
Conclusions
In a selected cohort of Danish patients with mGFR, the CKD-EPI21 equation performed slightly better than the CKD-EPI09-NB equation except for patients with a mGFR <60 mL/min/1.73 m2, where CKD-EPI09-NB performed slightly better although the differences were considered clinically insignificant.</description><subject>Chronic kidney failure</subject><subject>Comparative analysis</subject><subject>Epidemiology</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Medical care</subject><subject>Quality management</subject><subject>Transplantation of organs, tissues, etc</subject><issn>2048-8505</issn><issn>2048-8513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp90V9LwzAQAPAiCo65J79AQBBBuqVtuqaPY39UHCiizyG9XmzmmmxJi_jtjUwEQUweEi6_Oy5cFJ0ndJzQMpvA22bilazTPDuKBillPOZ5kh3_3Gl-Go2839Cwwgtl-SBqHtEp61ppAIlVpGuQOAkYK4dI5veLePl4R8Ch7LTRBuNKeqwJ3qyeCO77ELWGaEMkWUijfUPANtZ15F13DWlR-t4FHvRZdKLk1uPo-xxGL6vl8_w2Xj_c3M1n6xiyLOniukqhrjjIaSk5L2quSijyolSUMwYlVFUBqCioikENyIAV03yqaMJoFtqGbBhdHerunN336DvRag-43UqDtvci5WXBeJ7SJNCLA32VWxTaKNuFr39xMSuKaZmGjnhQ4z9U2DW2GqxBpUP8V8L1IQGc9d6hEjunW-k-RELF16REmJT4nlTQlwdt-92_8BP0cpNH</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Munch, Philip Vestergaard</creator><creator>Heide-Jørgensen, Uffe</creator><creator>Jensen, Simon Kok</creator><creator>Birn, Henrik</creator><creator>Vestergaard, Søren Viborg</creator><creator>Frøkiær, Jørgen</creator><creator>Sørensen, Henrik Toft</creator><creator>Christiansen, Christian Fynbo</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8407-4618</orcidid><orcidid>https://orcid.org/0000-0002-0032-131X</orcidid><orcidid>https://orcid.org/0000-0002-6206-8065</orcidid><orcidid>https://orcid.org/0000-0003-4299-7040</orcidid><orcidid>https://orcid.org/0000-0002-8239-2970</orcidid><orcidid>https://orcid.org/0000-0002-0727-953X</orcidid><orcidid>https://orcid.org/0000-0003-3715-7266</orcidid><orcidid>https://orcid.org/0000-0002-8445-7758</orcidid></search><sort><creationdate>20231201</creationdate><title>Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR</title><author>Munch, Philip Vestergaard ; Heide-Jørgensen, Uffe ; Jensen, Simon Kok ; Birn, Henrik ; Vestergaard, Søren Viborg ; Frøkiær, Jørgen ; Sørensen, Henrik Toft ; Christiansen, Christian Fynbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-db2cdb8ca69a887d8f9c7579f0844c9cbb7cef0cfb4cdce4c47656f01403acec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chronic kidney failure</topic><topic>Comparative analysis</topic><topic>Epidemiology</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Medical care</topic><topic>Quality management</topic><topic>Transplantation of organs, tissues, etc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Munch, Philip Vestergaard</creatorcontrib><creatorcontrib>Heide-Jørgensen, Uffe</creatorcontrib><creatorcontrib>Jensen, Simon Kok</creatorcontrib><creatorcontrib>Birn, Henrik</creatorcontrib><creatorcontrib>Vestergaard, Søren Viborg</creatorcontrib><creatorcontrib>Frøkiær, Jørgen</creatorcontrib><creatorcontrib>Sørensen, Henrik Toft</creatorcontrib><creatorcontrib>Christiansen, Christian Fynbo</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical kidney journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munch, Philip Vestergaard</au><au>Heide-Jørgensen, Uffe</au><au>Jensen, Simon Kok</au><au>Birn, Henrik</au><au>Vestergaard, Søren Viborg</au><au>Frøkiær, Jørgen</au><au>Sørensen, Henrik Toft</au><au>Christiansen, Christian Fynbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR</atitle><jtitle>Clinical kidney journal</jtitle><date>2023-12-01</date><risdate>2023</risdate><volume>16</volume><issue>12</issue><spage>2728</spage><epage>2737</epage><pages>2728-2737</pages><issn>2048-8505</issn><eissn>2048-8513</eissn><abstract>Background
In 2021, an updated Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) without a coefficient for race (CKD-EPI21) was developed. The performance of this new equation has yet to be examined among specific patient groups.
Methods
We compared the performances of the new CKD-EPI21 equation and the 2009 equation assuming non-Black race (CKD-EPI09-NB) in patients with GFR measured by chromium-51-EDTA plasma clearance at Aarhus University Hospital in Denmark during 2010–18. We examined bias, accuracy, precision and correct classification of chronic kidney disease (CKD) stage using chromium-51-EDTA clearance as the reference standard. We assessed the performance in the total cohort, cancer patients and potential living kidney donors. We also assessed the performance stratified by CKD stage in the total cohort.
Results
In this predominantly white population, the CKD-EPI21 equation performed slightly better than the CKD-EPI09-NB equation in both the total cohort (N = 4668), and in cancer patients (N = 3313) and potential living kidney donors (N = 239). In the total cohort, the CKD-EPI21 equation demonstrated a slightly lower median absolute bias (−0.2 versus −4.4 mL/min/1.73 m2), and a similar accuracy, precision and correct classification of CKD stage compared with the CKD-EPI09-NB equation. When stratified by CKD stage, the CKD-EPI09-NB equation performed slightly better than the CKD-EPI21 equation among patients with a measured GFR (mGFR) <60 mL/min/1.73 m2.
Conclusions
In a selected cohort of Danish patients with mGFR, the CKD-EPI21 equation performed slightly better than the CKD-EPI09-NB equation except for patients with a mGFR <60 mL/min/1.73 m2, where CKD-EPI09-NB performed slightly better although the differences were considered clinically insignificant.</abstract><pub>Oxford University Press</pub><doi>10.1093/ckj/sfad253</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8407-4618</orcidid><orcidid>https://orcid.org/0000-0002-0032-131X</orcidid><orcidid>https://orcid.org/0000-0002-6206-8065</orcidid><orcidid>https://orcid.org/0000-0003-4299-7040</orcidid><orcidid>https://orcid.org/0000-0002-8239-2970</orcidid><orcidid>https://orcid.org/0000-0002-0727-953X</orcidid><orcidid>https://orcid.org/0000-0003-3715-7266</orcidid><orcidid>https://orcid.org/0000-0002-8445-7758</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical kidney journal, 2023-12, Vol.16 (12), p.2728-2737 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Chronic kidney failure Comparative analysis Epidemiology Ethylenediaminetetraacetic acid Medical care Quality management Transplantation of organs, tissues, etc |
| title | Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR |
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