Pathogenic germline variants in non-BRCA1/2 homologous recombination genes in ovarian cancer: Analysis of tumor phenotype and survival

To define molecular features of ovarian cancer (OC) with germline pathogenic variants (PVs) in non-BRCA homologous recombination (HR) genes and analyze survival compared to BRCA1/2 and wildtype (WT) OC. We included patients with OC undergoing tumor-normal sequencing (MSK-IMPACT) from 07/01/2015–12/3...

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Veröffentlicht in:	Gynecologic oncology 2024-01, Vol.180, p.35-43
Hauptverfasser:	Kahn, Ryan M., Selenica, Pier, Boerner, Thomas, Roche, Kara Long, Xiao, Yonghong, Sia, Tiffany Y., Maio, Anna, Kemel, Yelena, Sheehan, Margaret, Salo-Mullen, Erin, Breen, Kelsey E., Zhou, Qin, Iasonos, Alexia, Grisham, Rachel N., O’Cearbhaill, Roisin E., Chi, Dennis S., Berger, Michael F., Kundra, Ritika, Schultz, Nikolaus, Ellenson, Lora H., Stadler, Zsofia K., Offit, Kenneth, Mandelker, Diana, Aghajanian, Carol, Zamarin, Dmitriy, Sabbatini, Paul, Weigelt, Britta, Liu, Ying L.
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 Protein - genetics BRCA1/2 BRCA2 Protein - genetics Female Genetic Predisposition to Disease Genetics Germ Cells - pathology Germ-Line Mutation Homologous Recombination Humans Ovarian cancer Ovarian Neoplasms - pathology Phenotype Poly (ADP-ribose) polymerase Survival
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