Systematic review of the risk of urolithiasis following parathyroidectomy in patients with primary hyperparathyroidism
Objective Parathyroidectomy (PTX) is the conclusive therapy for primary hyperparathyroidism (PHPT), but its effect on the risk of urolithiasis is inconclusive. We comprehensively reviewed the currently available research to investigate the impact of PTX on the likelihood of urolithiasis among indivi...
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| Veröffentlicht in: | International urology and nephrology 2024-04, Vol.56 (4), p.1217-1225 |
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| creator | Wang, Xingmu Shi, Ge Li, Gangfeng Tang, Guiliang |
| description | Objective
Parathyroidectomy (PTX) is the conclusive therapy for primary hyperparathyroidism (PHPT), but its effect on the risk of urolithiasis is inconclusive. We comprehensively reviewed the currently available research to investigate the impact of PTX on the likelihood of urolithiasis among individuals suffering PHPT.
Methods
Internet-based articles in English language released on Cochrane, PubMed, Scopus, Web of knowledge, and Embase up to September, 2023 were comprehensively reviewed. Each publication in contrast to the incidence, occurrence, or recurrence of urolithiasis after PTX versus medical treatment in PHPT patients was included. The outcome with pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) was examined employing DerSimonian and Laird’s model of random effects. To determine the range of the real effect size of a future study in 95% of all populations, a prediction interval (PI) was also established.
Results
Finally, ten studies involving 74,190 patients were included. Results from randomized-controlled trials (RCTs) and observational studies (OSs) both revealed that PTX did not substantially lessen the vulnerability of urolithiasis among individuals with PHPT (RCTs: pooled relative risk [RR] 0.42, 95%CI 0.13–1.41,
p
= 0.163; OSs: pooled RR 1.37, 95%CI 0.96 to 1.97,
p
= 0.084). The PI (RCT: 0.03 to 5.96; OSs: 0.44–4.20) containing 1.0 suggested the possibility of consistent results in future studies. Subgroup and sensitivity analyses supported the above findings, and no evidence showed publication bias.
Conclusion
Our analysis from the available RCTs or OSs did not give adequate or exact proof that the average effect of PTX lowers the incidence of urolithiasis among PHPT persons based on the random-effects model. Future research shall take into account the common effect of PTX as well as the prerequisites of preventive stone procedures, which will further help us assess the effectiveness of PTX in reducing kidney calculus comorbidity and develop techniques to avoid stone sequelae in these individuals. |
| doi_str_mv | 10.1007/s11255-023-03882-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2896811103</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2896811103</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-ff0734e6c230a28e61fc297a612a50b476829f111075d998a15bd9c3127d19da3</originalsourceid><addsrcrecordid>eNp9kTtPwzAUhS0EoqXwBxiQJRaWgB91Yo-o4iUhMQCz5SZO65LExXYa5d_jPoCKgclXvt859r0HgHOMrjFC2Y3HmDCWIEITRDknSXcAhphlNCGMjw_36gE48X6BEBIcoWMwoHwjoEOweu190LUKJodOr4zuoC1hmGvojP9Y162zlQlzo7zxsLRVZTvTzOBSORXmvbOm0HmwdQ9NEy-D0U3wsIsKuHSmVq6H836p3R5vfH0KjkpVeX22O0fg_f7ubfKYPL88PE1un5OckjQkZYkyOtZpTihShOsUlzkRmUoxUQxNx1nKiSgxxihjhRBcYTYtRE4xyQosCkVH4Grru3T2s9U-yNr4XFeVarRtvSRcpHytpxG9_IMubOua-DtJBKNkzGhc5wiQLZU7673TpdxNKTGS61TkNhUZU5GbJcsuii521u201sWP5DuGCNAt4GOrmWn3-_Y_tl-u3pqZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2953245357</pqid></control><display><type>article</type><title>Systematic review of the risk of urolithiasis following parathyroidectomy in patients with primary hyperparathyroidism</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Wang, Xingmu ; Shi, Ge ; Li, Gangfeng ; Tang, Guiliang</creator><creatorcontrib>Wang, Xingmu ; Shi, Ge ; Li, Gangfeng ; Tang, Guiliang</creatorcontrib><description>Objective
Parathyroidectomy (PTX) is the conclusive therapy for primary hyperparathyroidism (PHPT), but its effect on the risk of urolithiasis is inconclusive. We comprehensively reviewed the currently available research to investigate the impact of PTX on the likelihood of urolithiasis among individuals suffering PHPT.
Methods
Internet-based articles in English language released on Cochrane, PubMed, Scopus, Web of knowledge, and Embase up to September, 2023 were comprehensively reviewed. Each publication in contrast to the incidence, occurrence, or recurrence of urolithiasis after PTX versus medical treatment in PHPT patients was included. The outcome with pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) was examined employing DerSimonian and Laird’s model of random effects. To determine the range of the real effect size of a future study in 95% of all populations, a prediction interval (PI) was also established.
Results
Finally, ten studies involving 74,190 patients were included. Results from randomized-controlled trials (RCTs) and observational studies (OSs) both revealed that PTX did not substantially lessen the vulnerability of urolithiasis among individuals with PHPT (RCTs: pooled relative risk [RR] 0.42, 95%CI 0.13–1.41,
p
= 0.163; OSs: pooled RR 1.37, 95%CI 0.96 to 1.97,
p
= 0.084). The PI (RCT: 0.03 to 5.96; OSs: 0.44–4.20) containing 1.0 suggested the possibility of consistent results in future studies. Subgroup and sensitivity analyses supported the above findings, and no evidence showed publication bias.
Conclusion
Our analysis from the available RCTs or OSs did not give adequate or exact proof that the average effect of PTX lowers the incidence of urolithiasis among PHPT persons based on the random-effects model. Future research shall take into account the common effect of PTX as well as the prerequisites of preventive stone procedures, which will further help us assess the effectiveness of PTX in reducing kidney calculus comorbidity and develop techniques to avoid stone sequelae in these individuals.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-023-03882-w</identifier><identifier>PMID: 38038823</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Calculi ; Clinical trials ; Comorbidity ; Complications ; Humans ; Hyperparathyroidism ; Hyperparathyroidism, Primary - complications ; Hyperparathyroidism, Primary - surgery ; Lithiasis ; Medical treatment ; Medicine ; Medicine & Public Health ; Nephrology ; Parathyroidectomy ; Patients ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Risk Assessment ; Sensitivity analysis ; Urinary tract diseases ; Urolithiasis - etiology ; Urolithiasis - surgery ; Urology ; Urology - Review</subject><ispartof>International urology and nephrology, 2024-04, Vol.56 (4), p.1217-1225</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-ff0734e6c230a28e61fc297a612a50b476829f111075d998a15bd9c3127d19da3</cites><orcidid>0009-0000-2611-1495</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-023-03882-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-023-03882-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38038823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xingmu</creatorcontrib><creatorcontrib>Shi, Ge</creatorcontrib><creatorcontrib>Li, Gangfeng</creatorcontrib><creatorcontrib>Tang, Guiliang</creatorcontrib><title>Systematic review of the risk of urolithiasis following parathyroidectomy in patients with primary hyperparathyroidism</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Objective
Parathyroidectomy (PTX) is the conclusive therapy for primary hyperparathyroidism (PHPT), but its effect on the risk of urolithiasis is inconclusive. We comprehensively reviewed the currently available research to investigate the impact of PTX on the likelihood of urolithiasis among individuals suffering PHPT.
Methods
Internet-based articles in English language released on Cochrane, PubMed, Scopus, Web of knowledge, and Embase up to September, 2023 were comprehensively reviewed. Each publication in contrast to the incidence, occurrence, or recurrence of urolithiasis after PTX versus medical treatment in PHPT patients was included. The outcome with pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) was examined employing DerSimonian and Laird’s model of random effects. To determine the range of the real effect size of a future study in 95% of all populations, a prediction interval (PI) was also established.
Results
Finally, ten studies involving 74,190 patients were included. Results from randomized-controlled trials (RCTs) and observational studies (OSs) both revealed that PTX did not substantially lessen the vulnerability of urolithiasis among individuals with PHPT (RCTs: pooled relative risk [RR] 0.42, 95%CI 0.13–1.41,
p
= 0.163; OSs: pooled RR 1.37, 95%CI 0.96 to 1.97,
p
= 0.084). The PI (RCT: 0.03 to 5.96; OSs: 0.44–4.20) containing 1.0 suggested the possibility of consistent results in future studies. Subgroup and sensitivity analyses supported the above findings, and no evidence showed publication bias.
Conclusion
Our analysis from the available RCTs or OSs did not give adequate or exact proof that the average effect of PTX lowers the incidence of urolithiasis among PHPT persons based on the random-effects model. Future research shall take into account the common effect of PTX as well as the prerequisites of preventive stone procedures, which will further help us assess the effectiveness of PTX in reducing kidney calculus comorbidity and develop techniques to avoid stone sequelae in these individuals.</description><subject>Calculi</subject><subject>Clinical trials</subject><subject>Comorbidity</subject><subject>Complications</subject><subject>Humans</subject><subject>Hyperparathyroidism</subject><subject>Hyperparathyroidism, Primary - complications</subject><subject>Hyperparathyroidism, Primary - surgery</subject><subject>Lithiasis</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Parathyroidectomy</subject><subject>Patients</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Risk Assessment</subject><subject>Sensitivity analysis</subject><subject>Urinary tract diseases</subject><subject>Urolithiasis - etiology</subject><subject>Urolithiasis - surgery</subject><subject>Urology</subject><subject>Urology - Review</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kTtPwzAUhS0EoqXwBxiQJRaWgB91Yo-o4iUhMQCz5SZO65LExXYa5d_jPoCKgclXvt859r0HgHOMrjFC2Y3HmDCWIEITRDknSXcAhphlNCGMjw_36gE48X6BEBIcoWMwoHwjoEOweu190LUKJodOr4zuoC1hmGvojP9Y162zlQlzo7zxsLRVZTvTzOBSORXmvbOm0HmwdQ9NEy-D0U3wsIsKuHSmVq6H836p3R5vfH0KjkpVeX22O0fg_f7ubfKYPL88PE1un5OckjQkZYkyOtZpTihShOsUlzkRmUoxUQxNx1nKiSgxxihjhRBcYTYtRE4xyQosCkVH4Grru3T2s9U-yNr4XFeVarRtvSRcpHytpxG9_IMubOua-DtJBKNkzGhc5wiQLZU7673TpdxNKTGS61TkNhUZU5GbJcsuii521u201sWP5DuGCNAt4GOrmWn3-_Y_tl-u3pqZ</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Wang, Xingmu</creator><creator>Shi, Ge</creator><creator>Li, Gangfeng</creator><creator>Tang, Guiliang</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0000-2611-1495</orcidid></search><sort><creationdate>20240401</creationdate><title>Systematic review of the risk of urolithiasis following parathyroidectomy in patients with primary hyperparathyroidism</title><author>Wang, Xingmu ; Shi, Ge ; Li, Gangfeng ; Tang, Guiliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-ff0734e6c230a28e61fc297a612a50b476829f111075d998a15bd9c3127d19da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Calculi</topic><topic>Clinical trials</topic><topic>Comorbidity</topic><topic>Complications</topic><topic>Humans</topic><topic>Hyperparathyroidism</topic><topic>Hyperparathyroidism, Primary - complications</topic><topic>Hyperparathyroidism, Primary - surgery</topic><topic>Lithiasis</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Parathyroidectomy</topic><topic>Patients</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Risk Assessment</topic><topic>Sensitivity analysis</topic><topic>Urinary tract diseases</topic><topic>Urolithiasis - etiology</topic><topic>Urolithiasis - surgery</topic><topic>Urology</topic><topic>Urology - Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xingmu</creatorcontrib><creatorcontrib>Shi, Ge</creatorcontrib><creatorcontrib>Li, Gangfeng</creatorcontrib><creatorcontrib>Tang, Guiliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xingmu</au><au>Shi, Ge</au><au>Li, Gangfeng</au><au>Tang, Guiliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systematic review of the risk of urolithiasis following parathyroidectomy in patients with primary hyperparathyroidism</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>56</volume><issue>4</issue><spage>1217</spage><epage>1225</epage><pages>1217-1225</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Objective
Parathyroidectomy (PTX) is the conclusive therapy for primary hyperparathyroidism (PHPT), but its effect on the risk of urolithiasis is inconclusive. We comprehensively reviewed the currently available research to investigate the impact of PTX on the likelihood of urolithiasis among individuals suffering PHPT.
Methods
Internet-based articles in English language released on Cochrane, PubMed, Scopus, Web of knowledge, and Embase up to September, 2023 were comprehensively reviewed. Each publication in contrast to the incidence, occurrence, or recurrence of urolithiasis after PTX versus medical treatment in PHPT patients was included. The outcome with pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) was examined employing DerSimonian and Laird’s model of random effects. To determine the range of the real effect size of a future study in 95% of all populations, a prediction interval (PI) was also established.
Results
Finally, ten studies involving 74,190 patients were included. Results from randomized-controlled trials (RCTs) and observational studies (OSs) both revealed that PTX did not substantially lessen the vulnerability of urolithiasis among individuals with PHPT (RCTs: pooled relative risk [RR] 0.42, 95%CI 0.13–1.41,
p
= 0.163; OSs: pooled RR 1.37, 95%CI 0.96 to 1.97,
p
= 0.084). The PI (RCT: 0.03 to 5.96; OSs: 0.44–4.20) containing 1.0 suggested the possibility of consistent results in future studies. Subgroup and sensitivity analyses supported the above findings, and no evidence showed publication bias.
Conclusion
Our analysis from the available RCTs or OSs did not give adequate or exact proof that the average effect of PTX lowers the incidence of urolithiasis among PHPT persons based on the random-effects model. Future research shall take into account the common effect of PTX as well as the prerequisites of preventive stone procedures, which will further help us assess the effectiveness of PTX in reducing kidney calculus comorbidity and develop techniques to avoid stone sequelae in these individuals.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38038823</pmid><doi>10.1007/s11255-023-03882-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0009-0000-2611-1495</orcidid></addata></record> |
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| ispartof | International urology and nephrology, 2024-04, Vol.56 (4), p.1217-1225 |
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| subjects | Calculi Clinical trials Comorbidity Complications Humans Hyperparathyroidism Hyperparathyroidism, Primary - complications Hyperparathyroidism, Primary - surgery Lithiasis Medical treatment Medicine Medicine & Public Health Nephrology Parathyroidectomy Patients Postoperative Complications - epidemiology Postoperative Complications - etiology Risk Assessment Sensitivity analysis Urinary tract diseases Urolithiasis - etiology Urolithiasis - surgery Urology Urology - Review |
| title | Systematic review of the risk of urolithiasis following parathyroidectomy in patients with primary hyperparathyroidism |
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