Somatostatin receptor2 (SSTR2) expression, prognostic implications, modifications and potential therapeutic strategies associates with head and neck squamous cell carcinomas
Head and neck squamous cell carcinomas (HNSCC) constitute a heterogeneous cluster of tumors celebrated for their predisposition to metastasize and exhibit local recurrence. Recent explorations have illuminated the intricate involvement of Somatostatin Receptor 2 (SSTR2), a growth-regulatory receptor...
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| Veröffentlicht in: | Critical reviews in oncology/hematology 2024-01, Vol.193, p.104223-104223, Article 104223 |
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| container_title | Critical reviews in oncology/hematology |
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| creator | Fan, Songqing Zheng, Hongmei Zhan, Yuting Luo, Jiadi Zang, Hongjing Wang, Huilin Wang, Weiyuan Xu, Yue |
| description | Head and neck squamous cell carcinomas (HNSCC) constitute a heterogeneous cluster of tumors celebrated for their predisposition to metastasize and exhibit local recurrence. Recent explorations have illuminated the intricate involvement of Somatostatin Receptor 2 (SSTR2), a growth-regulatory receptor traditionally classified as a tumor suppressor, yet concurrently implicated in bolstering specific tumor phenotypes. Advances in the realm of SSTR2 investigation within HNSCC, with a specific spotlight on laryngeal squamous cell carcinomas (LSCC), tongue squamous cell carcinomas (TSCC), and nasopharyngeal carcinomas (NPC), have been established. This study aims to provide a comprehensive overview of SSTR2 expression patterns, prognostic implications, distinctive signaling pathways, epigenetic modifications, and potential therapeutic strategies associated with SSTR2 in HNSCC.
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•Expression and prognosis significance of SSTR2 in HNSCC. encompassing NPC, TSCC and LSCC.•At the mRNA level, the signaling pathway involved by SSTR2 in NPC may be different from other HNSCC.•SSTR2 expression is regulated by epigenetic modifications, and methylation of SSTR2 results in low gene expression.•Potential detection and treatment methods related to SSTR2 in HNSCC. |
| doi_str_mv | 10.1016/j.critrevonc.2023.104223 |
| format | Article |
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[Display omitted]
•Expression and prognosis significance of SSTR2 in HNSCC. encompassing NPC, TSCC and LSCC.•At the mRNA level, the signaling pathway involved by SSTR2 in NPC may be different from other HNSCC.•SSTR2 expression is regulated by epigenetic modifications, and methylation of SSTR2 results in low gene expression.•Potential detection and treatment methods related to SSTR2 in HNSCC.</description><identifier>ISSN: 1040-8428</identifier><identifier>EISSN: 1879-0461</identifier><identifier>DOI: 10.1016/j.critrevonc.2023.104223</identifier><identifier>PMID: 38036157</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biomarkers, Tumor - genetics ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - therapy ; Head and Neck Neoplasms - diagnosis ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - therapy ; Head and neck squamous cell carcinomas ; Humans ; Methylation ; Prognosis ; Somatostatin ; Somatostatin Receptor 2 ; Squamous Cell Carcinoma of Head and Neck - diagnosis ; Squamous Cell Carcinoma of Head and Neck - genetics ; Squamous Cell Carcinoma of Head and Neck - therapy ; Therapy</subject><ispartof>Critical reviews in oncology/hematology, 2024-01, Vol.193, p.104223-104223, Article 104223</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c319t-dce135d3b76d81fcea673efea45730a157a131da778d849c79381ff3dc1f77a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1040842823003116$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38036157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Songqing</creatorcontrib><creatorcontrib>Zheng, Hongmei</creatorcontrib><creatorcontrib>Zhan, Yuting</creatorcontrib><creatorcontrib>Luo, Jiadi</creatorcontrib><creatorcontrib>Zang, Hongjing</creatorcontrib><creatorcontrib>Wang, Huilin</creatorcontrib><creatorcontrib>Wang, Weiyuan</creatorcontrib><creatorcontrib>Xu, Yue</creatorcontrib><title>Somatostatin receptor2 (SSTR2) expression, prognostic implications, modifications and potential therapeutic strategies associates with head and neck squamous cell carcinomas</title><title>Critical reviews in oncology/hematology</title><addtitle>Crit Rev Oncol Hematol</addtitle><description>Head and neck squamous cell carcinomas (HNSCC) constitute a heterogeneous cluster of tumors celebrated for their predisposition to metastasize and exhibit local recurrence. Recent explorations have illuminated the intricate involvement of Somatostatin Receptor 2 (SSTR2), a growth-regulatory receptor traditionally classified as a tumor suppressor, yet concurrently implicated in bolstering specific tumor phenotypes. Advances in the realm of SSTR2 investigation within HNSCC, with a specific spotlight on laryngeal squamous cell carcinomas (LSCC), tongue squamous cell carcinomas (TSCC), and nasopharyngeal carcinomas (NPC), have been established. This study aims to provide a comprehensive overview of SSTR2 expression patterns, prognostic implications, distinctive signaling pathways, epigenetic modifications, and potential therapeutic strategies associated with SSTR2 in HNSCC.
[Display omitted]
•Expression and prognosis significance of SSTR2 in HNSCC. encompassing NPC, TSCC and LSCC.•At the mRNA level, the signaling pathway involved by SSTR2 in NPC may be different from other HNSCC.•SSTR2 expression is regulated by epigenetic modifications, and methylation of SSTR2 results in low gene expression.•Potential detection and treatment methods related to SSTR2 in HNSCC.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Head and neck squamous cell carcinomas</subject><subject>Humans</subject><subject>Methylation</subject><subject>Prognosis</subject><subject>Somatostatin</subject><subject>Somatostatin Receptor 2</subject><subject>Squamous Cell Carcinoma of Head and Neck - diagnosis</subject><subject>Squamous Cell Carcinoma of Head and Neck - genetics</subject><subject>Squamous Cell Carcinoma of Head and Neck - therapy</subject><subject>Therapy</subject><issn>1040-8428</issn><issn>1879-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1u1DAQhS0EoqXwCsiXRWoW_2Rj5xIqCkiVkNhybbn2pOslsVOPU-Ch-o542RYuubJn9B3PGR9CKGcrznj3drdyOZQMdym6lWBC1nYrhHxCjrlWfcPajj-td9ayRrdCH5EXiDvGWNt26jk5kprJjq_VMbnfpMmWhMWWEGkGB3NJWdDTzebqq3hD4eecATGkeEbnnG5iRYOjYZrH4KomRTyjU_JheCypjZ7OqUAswY60bCHbGZa9Cku2BW4CVAgxuVArpD9C2dItWP9HGcF9p3i72CktSB2MI3U2uxCrT3xJng12RHj1cJ6Qbxcfrs4_NZdfPn4-f3fZOMn70ngHXK69vFad13xwYDslYQDbrpVkti5uueTeKqW9bnunelmxQXrHB6Uskyfk9PBuXfl2ASxmCrj3YiNUW0bovtP1dztRUX1AXU6IGQYz5zDZ_MtwZvZhmZ35F5bZh2UOYVXp64cpy_UE_q_wMZ0KvD8AUHe9C5ANugDRgQ81qWJ8Cv-f8ht8M7Bt</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Fan, Songqing</creator><creator>Zheng, Hongmei</creator><creator>Zhan, Yuting</creator><creator>Luo, Jiadi</creator><creator>Zang, Hongjing</creator><creator>Wang, Huilin</creator><creator>Wang, Weiyuan</creator><creator>Xu, Yue</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202401</creationdate><title>Somatostatin receptor2 (SSTR2) expression, prognostic implications, modifications and potential therapeutic strategies associates with head and neck squamous cell carcinomas</title><author>Fan, Songqing ; Zheng, Hongmei ; Zhan, Yuting ; Luo, Jiadi ; Zang, Hongjing ; Wang, Huilin ; Wang, Weiyuan ; Xu, Yue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-dce135d3b76d81fcea673efea45730a157a131da778d849c79381ff3dc1f77a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Head and neck squamous cell carcinomas</topic><topic>Humans</topic><topic>Methylation</topic><topic>Prognosis</topic><topic>Somatostatin</topic><topic>Somatostatin Receptor 2</topic><topic>Squamous Cell Carcinoma of Head and Neck - diagnosis</topic><topic>Squamous Cell Carcinoma of Head and Neck - genetics</topic><topic>Squamous Cell Carcinoma of Head and Neck - therapy</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Songqing</creatorcontrib><creatorcontrib>Zheng, Hongmei</creatorcontrib><creatorcontrib>Zhan, Yuting</creatorcontrib><creatorcontrib>Luo, Jiadi</creatorcontrib><creatorcontrib>Zang, Hongjing</creatorcontrib><creatorcontrib>Wang, Huilin</creatorcontrib><creatorcontrib>Wang, Weiyuan</creatorcontrib><creatorcontrib>Xu, Yue</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical reviews in oncology/hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Songqing</au><au>Zheng, Hongmei</au><au>Zhan, Yuting</au><au>Luo, Jiadi</au><au>Zang, Hongjing</au><au>Wang, Huilin</au><au>Wang, Weiyuan</au><au>Xu, Yue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatostatin receptor2 (SSTR2) expression, prognostic implications, modifications and potential therapeutic strategies associates with head and neck squamous cell carcinomas</atitle><jtitle>Critical reviews in oncology/hematology</jtitle><addtitle>Crit Rev Oncol Hematol</addtitle><date>2024-01</date><risdate>2024</risdate><volume>193</volume><spage>104223</spage><epage>104223</epage><pages>104223-104223</pages><artnum>104223</artnum><issn>1040-8428</issn><eissn>1879-0461</eissn><abstract>Head and neck squamous cell carcinomas (HNSCC) constitute a heterogeneous cluster of tumors celebrated for their predisposition to metastasize and exhibit local recurrence. Recent explorations have illuminated the intricate involvement of Somatostatin Receptor 2 (SSTR2), a growth-regulatory receptor traditionally classified as a tumor suppressor, yet concurrently implicated in bolstering specific tumor phenotypes. Advances in the realm of SSTR2 investigation within HNSCC, with a specific spotlight on laryngeal squamous cell carcinomas (LSCC), tongue squamous cell carcinomas (TSCC), and nasopharyngeal carcinomas (NPC), have been established. This study aims to provide a comprehensive overview of SSTR2 expression patterns, prognostic implications, distinctive signaling pathways, epigenetic modifications, and potential therapeutic strategies associated with SSTR2 in HNSCC.
[Display omitted]
•Expression and prognosis significance of SSTR2 in HNSCC. encompassing NPC, TSCC and LSCC.•At the mRNA level, the signaling pathway involved by SSTR2 in NPC may be different from other HNSCC.•SSTR2 expression is regulated by epigenetic modifications, and methylation of SSTR2 results in low gene expression.•Potential detection and treatment methods related to SSTR2 in HNSCC.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38036157</pmid><doi>10.1016/j.critrevonc.2023.104223</doi><tpages>1</tpages></addata></record> |
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| subjects | Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - therapy Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - genetics Head and Neck Neoplasms - therapy Head and neck squamous cell carcinomas Humans Methylation Prognosis Somatostatin Somatostatin Receptor 2 Squamous Cell Carcinoma of Head and Neck - diagnosis Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - therapy Therapy |
| title | Somatostatin receptor2 (SSTR2) expression, prognostic implications, modifications and potential therapeutic strategies associates with head and neck squamous cell carcinomas |
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