Dihydromyricetin protects against gentamicin-induced nephrotoxicity via upregulation of renal SIRT3 and PAX2

Gentamicin-induced nephrotoxicity limits its widespread use as an effective antibacterial agent. Oxidative stress, inflammatory cytokines and apoptotic cell death are major participants in gentamicin-induced nephrotoxicity. We therefore, investigated whether dihydromyricetin (DHM), the antioxidant a...

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Veröffentlicht in:	Life sciences (1973) 2024-01, Vol.336, p.122318-122318, Article 122318
Hauptverfasser:	Matouk, Asmaa I, Awad, Eman M, Mousa, Amr A K, Abdelhafez, Sara M N, Fahmy, Usama A, El-Moselhy, Mohamed A, Abdel-Naim, Ashraf B, Anter, Aliaa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Antioxidants - metabolism Antioxidants - pharmacology Drug-Related Side Effects and Adverse Reactions Gentamicins - toxicity Humans Kidney - metabolism Male Oxidative Stress PAX2 Transcription Factor - metabolism Rats Rats, Wistar Sirtuin 3 - metabolism Up-Regulation
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