Insomnia in epilepsy is associated with nocturnal seizures and anxiety
The purpose of this study was to identify the factors associated with insomnia in patients with epilepsy (PWE) and provide evidence for clinical prevention and treatment. PWE who visited our epilepsy clinic from December 2021 to December 2022 were enrolled in our study. All participants completed th...
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| Veröffentlicht in: | Epilepsy & behavior 2024-01, Vol.150, p.109559-109559, Article 109559 |
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| container_title | Epilepsy & behavior |
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| creator | Tan, Bofei Liu, Qiang Qin, Yameng Chen, Qiuyan Chen, Rong Jin, Yanzi Li, Mengyun Jia, Xiaodan Xu, Xianrui Zhang, Qing |
| description | The purpose of this study was to identify the factors associated with insomnia in patients with epilepsy (PWE) and provide evidence for clinical prevention and treatment.
PWE who visited our epilepsy clinic from December 2021 to December 2022 were enrolled in our study. All participants completed the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). Based on their ISI scores, they were categorized into two groups: PWE with insomnia (ISI score ≥ 10) and PWE without insomnia (ISI score |
| doi_str_mv | 10.1016/j.yebeh.2023.109559 |
| format | Article |
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PWE who visited our epilepsy clinic from December 2021 to December 2022 were enrolled in our study. All participants completed the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). Based on their ISI scores, they were categorized into two groups: PWE with insomnia (ISI score ≥ 10) and PWE without insomnia (ISI score < 10). Univariate analysis and stepwise logistic regression analysis were conducted to identify the factors associated with insomnia in PWE.
A total of 196 Chinese PWE were recruited in this study(men, 39.8 %). Of these, 39 PWE(19.9 %) had insomnia.The incidence of nocturnal seizures (43.6 %vs19.7 %), depression (46.2 %vs9.6 %), anxiety (59.0 %vs11.5 %), and excessive daytime sleepiness(EDS,28.2 %vs5.7 %) in PWE with insomnia were significantly higher than in those without insomnia(all p＜0.01). Univariate regression analysis showed that seizures greater than or equal to once per month, nocturnal seizures, anxiety, depression, and EDS may associate with insomnia in PWE(all p＜0.05). Stepwise logistic regression analysis demonstrated that nocturnal seizures (OR = 2.611,95 % CI 1.040-6.478, P = 0.038) and anxiety (mild OR = 4.830,95 %CI 1.741-13.186, P = 0.002;moderate OR = 24.239,95 %CI 4.719-183.935, P＜0.001; severe OR = 37.653,95 %CI 4.931-782.741, P = 0.002) were independently associated with insomnia in PWE.
PWE with insomnia are more likely to experience depression and EDS. Nocturnal seizures and anxiety are identified as independent factors associated with insomnia in PWE. Furthermore, Anxiety has a greater impact on insomnia in PWE and the likelihood of insomnia has increased significantly with the aggravation of anxiety levels.</description><identifier>ISSN: 1525-5050</identifier><identifier>EISSN: 1525-5069</identifier><identifier>DOI: 10.1016/j.yebeh.2023.109559</identifier><identifier>PMID: 38035537</identifier><language>eng</language><publisher>United States</publisher><subject>Anxiety - complications ; Anxiety - epidemiology ; Anxiety Disorders ; Epilepsy, Reflex ; Humans ; Male ; Seizures - complications ; Seizures - drug therapy ; Seizures - epidemiology ; Sleep Initiation and Maintenance Disorders - complications ; Sleep Initiation and Maintenance Disorders - epidemiology</subject><ispartof>Epilepsy & behavior, 2024-01, Vol.150, p.109559-109559, Article 109559</ispartof><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-8ad0744bfa4e9c7e2c18b5ce1eaada2339e4789be6884ef98726bcf147af71333</citedby><cites>FETCH-LOGICAL-c305t-8ad0744bfa4e9c7e2c18b5ce1eaada2339e4789be6884ef98726bcf147af71333</cites><orcidid>0009-0000-1928-4910 ; 0009-0002-5275-5256 ; 0009-0005-7221-8265</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38035537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Bofei</creatorcontrib><creatorcontrib>Liu, Qiang</creatorcontrib><creatorcontrib>Qin, Yameng</creatorcontrib><creatorcontrib>Chen, Qiuyan</creatorcontrib><creatorcontrib>Chen, Rong</creatorcontrib><creatorcontrib>Jin, Yanzi</creatorcontrib><creatorcontrib>Li, Mengyun</creatorcontrib><creatorcontrib>Jia, Xiaodan</creatorcontrib><creatorcontrib>Xu, Xianrui</creatorcontrib><creatorcontrib>Zhang, Qing</creatorcontrib><title>Insomnia in epilepsy is associated with nocturnal seizures and anxiety</title><title>Epilepsy & behavior</title><addtitle>Epilepsy Behav</addtitle><description>The purpose of this study was to identify the factors associated with insomnia in patients with epilepsy (PWE) and provide evidence for clinical prevention and treatment.
PWE who visited our epilepsy clinic from December 2021 to December 2022 were enrolled in our study. All participants completed the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). Based on their ISI scores, they were categorized into two groups: PWE with insomnia (ISI score ≥ 10) and PWE without insomnia (ISI score < 10). Univariate analysis and stepwise logistic regression analysis were conducted to identify the factors associated with insomnia in PWE.
A total of 196 Chinese PWE were recruited in this study(men, 39.8 %). Of these, 39 PWE(19.9 %) had insomnia.The incidence of nocturnal seizures (43.6 %vs19.7 %), depression (46.2 %vs9.6 %), anxiety (59.0 %vs11.5 %), and excessive daytime sleepiness(EDS,28.2 %vs5.7 %) in PWE with insomnia were significantly higher than in those without insomnia(all p＜0.01). Univariate regression analysis showed that seizures greater than or equal to once per month, nocturnal seizures, anxiety, depression, and EDS may associate with insomnia in PWE(all p＜0.05). Stepwise logistic regression analysis demonstrated that nocturnal seizures (OR = 2.611,95 % CI 1.040-6.478, P = 0.038) and anxiety (mild OR = 4.830,95 %CI 1.741-13.186, P = 0.002;moderate OR = 24.239,95 %CI 4.719-183.935, P＜0.001; severe OR = 37.653,95 %CI 4.931-782.741, P = 0.002) were independently associated with insomnia in PWE.
PWE with insomnia are more likely to experience depression and EDS. Nocturnal seizures and anxiety are identified as independent factors associated with insomnia in PWE. Furthermore, Anxiety has a greater impact on insomnia in PWE and the likelihood of insomnia has increased significantly with the aggravation of anxiety levels.</description><subject>Anxiety - complications</subject><subject>Anxiety - epidemiology</subject><subject>Anxiety Disorders</subject><subject>Epilepsy, Reflex</subject><subject>Humans</subject><subject>Male</subject><subject>Seizures - complications</subject><subject>Seizures - drug therapy</subject><subject>Seizures - epidemiology</subject><subject>Sleep Initiation and Maintenance Disorders - complications</subject><subject>Sleep Initiation and Maintenance Disorders - epidemiology</subject><issn>1525-5050</issn><issn>1525-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN9LwzAQx4Mobk7_AkH66EtnfjRN8ijD6WDgiz6HNL2yjDatSYvWv97O6R6OO47P9w4-CN0SvCSY5A_75QgF7JYUUzZtFOfqDM0JpzzlOFfnp5njGbqKcY8xIZyRSzRjEjPOmZij9cbHtvHOJM4n0LkaujgmLiYmxtY600OZfLp-l_jW9kPwpk4iuO8hwIT4cqovB_14jS4qU0e4-esL9L5-elu9pNvX583qcZtahnmfSlNikWVFZTJQVgC1RBbcAgFjSkMZU5AJqQrIpcygUlLQvLAVyYSpBGGMLdD98W4X2o8BYq8bFy3UtfHQDlFTqXKJlRB8QtkRtaGNMUClu-AaE0ZNsD4I1Hv9K1AfBOqjwCl19_dgKBooT5l_Y-wHRz1ujw</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Tan, Bofei</creator><creator>Liu, Qiang</creator><creator>Qin, Yameng</creator><creator>Chen, Qiuyan</creator><creator>Chen, Rong</creator><creator>Jin, Yanzi</creator><creator>Li, Mengyun</creator><creator>Jia, Xiaodan</creator><creator>Xu, Xianrui</creator><creator>Zhang, Qing</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0000-1928-4910</orcidid><orcidid>https://orcid.org/0009-0002-5275-5256</orcidid><orcidid>https://orcid.org/0009-0005-7221-8265</orcidid></search><sort><creationdate>202401</creationdate><title>Insomnia in epilepsy is associated with nocturnal seizures and anxiety</title><author>Tan, Bofei ; Liu, Qiang ; Qin, Yameng ; Chen, Qiuyan ; Chen, Rong ; Jin, Yanzi ; Li, Mengyun ; Jia, Xiaodan ; Xu, Xianrui ; Zhang, Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-8ad0744bfa4e9c7e2c18b5ce1eaada2339e4789be6884ef98726bcf147af71333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anxiety - complications</topic><topic>Anxiety - epidemiology</topic><topic>Anxiety Disorders</topic><topic>Epilepsy, Reflex</topic><topic>Humans</topic><topic>Male</topic><topic>Seizures - complications</topic><topic>Seizures - drug therapy</topic><topic>Seizures - epidemiology</topic><topic>Sleep Initiation and Maintenance Disorders - complications</topic><topic>Sleep Initiation and Maintenance Disorders - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Bofei</creatorcontrib><creatorcontrib>Liu, Qiang</creatorcontrib><creatorcontrib>Qin, Yameng</creatorcontrib><creatorcontrib>Chen, Qiuyan</creatorcontrib><creatorcontrib>Chen, Rong</creatorcontrib><creatorcontrib>Jin, Yanzi</creatorcontrib><creatorcontrib>Li, Mengyun</creatorcontrib><creatorcontrib>Jia, Xiaodan</creatorcontrib><creatorcontrib>Xu, Xianrui</creatorcontrib><creatorcontrib>Zhang, Qing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Bofei</au><au>Liu, Qiang</au><au>Qin, Yameng</au><au>Chen, Qiuyan</au><au>Chen, Rong</au><au>Jin, Yanzi</au><au>Li, Mengyun</au><au>Jia, Xiaodan</au><au>Xu, Xianrui</au><au>Zhang, Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insomnia in epilepsy is associated with nocturnal seizures and anxiety</atitle><jtitle>Epilepsy & behavior</jtitle><addtitle>Epilepsy Behav</addtitle><date>2024-01</date><risdate>2024</risdate><volume>150</volume><spage>109559</spage><epage>109559</epage><pages>109559-109559</pages><artnum>109559</artnum><issn>1525-5050</issn><eissn>1525-5069</eissn><abstract>The purpose of this study was to identify the factors associated with insomnia in patients with epilepsy (PWE) and provide evidence for clinical prevention and treatment.
PWE who visited our epilepsy clinic from December 2021 to December 2022 were enrolled in our study. All participants completed the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). Based on their ISI scores, they were categorized into two groups: PWE with insomnia (ISI score ≥ 10) and PWE without insomnia (ISI score < 10). Univariate analysis and stepwise logistic regression analysis were conducted to identify the factors associated with insomnia in PWE.
A total of 196 Chinese PWE were recruited in this study(men, 39.8 %). Of these, 39 PWE(19.9 %) had insomnia.The incidence of nocturnal seizures (43.6 %vs19.7 %), depression (46.2 %vs9.6 %), anxiety (59.0 %vs11.5 %), and excessive daytime sleepiness(EDS,28.2 %vs5.7 %) in PWE with insomnia were significantly higher than in those without insomnia(all p＜0.01). Univariate regression analysis showed that seizures greater than or equal to once per month, nocturnal seizures, anxiety, depression, and EDS may associate with insomnia in PWE(all p＜0.05). Stepwise logistic regression analysis demonstrated that nocturnal seizures (OR = 2.611,95 % CI 1.040-6.478, P = 0.038) and anxiety (mild OR = 4.830,95 %CI 1.741-13.186, P = 0.002;moderate OR = 24.239,95 %CI 4.719-183.935, P＜0.001; severe OR = 37.653,95 %CI 4.931-782.741, P = 0.002) were independently associated with insomnia in PWE.
PWE with insomnia are more likely to experience depression and EDS. Nocturnal seizures and anxiety are identified as independent factors associated with insomnia in PWE. Furthermore, Anxiety has a greater impact on insomnia in PWE and the likelihood of insomnia has increased significantly with the aggravation of anxiety levels.</abstract><cop>United States</cop><pmid>38035537</pmid><doi>10.1016/j.yebeh.2023.109559</doi><tpages>1</tpages><orcidid>https://orcid.org/0009-0000-1928-4910</orcidid><orcidid>https://orcid.org/0009-0002-5275-5256</orcidid><orcidid>https://orcid.org/0009-0005-7221-8265</orcidid></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anxiety - complications Anxiety - epidemiology Anxiety Disorders Epilepsy, Reflex Humans Male Seizures - complications Seizures - drug therapy Seizures - epidemiology Sleep Initiation and Maintenance Disorders - complications Sleep Initiation and Maintenance Disorders - epidemiology |
| title | Insomnia in epilepsy is associated with nocturnal seizures and anxiety |
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