Premorbid intelligence quotient and school failure as risk markers for bipolar disorder and major depressive disorder
Mood disorders significantly impact global health, with MDD ranking as the second leading cause of disability in the United States and BD ranking 18th. Despite their prevalence and impact, the relationship between premorbid intelligence and the subsequent development of BD and MDD remains inconclusi...
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| Veröffentlicht in: | Journal of psychiatric research 2024-01, Vol.169, p.160-165 |
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| creator | Rabelo-da-Ponte, Francisco Diego Marchionatti, Lauro Estivalete Watts, Devon Roza, Thiago Henrique Amoretti, Silvia Barros, Fernando C Wehrmeister, Fernando C Gonçalves, Helen B Menezes, Ana Maria Kunz, Maurício Kapczinski, Flávio Passos, Ives Cavalcante |
| description | Mood disorders significantly impact global health, with MDD ranking as the second leading cause of disability in the United States and BD ranking 18th. Despite their prevalence and impact, the relationship between premorbid intelligence and the subsequent development of BD and MDD remains inconclusive. This study investigates the potential of premorbid Intelligence Quotient (IQ) and school failure frequency as risk factors for Bipolar Disorder (BD) and Major Depressive Disorder (MDD) in a birth cohort setting. We analyze data from the Pelotas population-based birth cohort study, comprising 3580 participants aged 22, who had no prior mood disorder diagnoses. Utilizing regression models and accounting for potential confounders, we assess the impact of IQ and school failure, measured at age 18, on the emergence of BD and MDD diagnoses at age 22, using individuals without mood disorders as comparators. Results reveal that lower IQ (below 70) at 18 is associated with an increased risk of BD (Adjusted Odds Ratio [AOR] 1.75, 95%CI: 1.00-3.09, p |
| doi_str_mv | 10.1016/j.jpsychires.2023.11.018 |
| format | Article |
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Despite their prevalence and impact, the relationship between premorbid intelligence and the subsequent development of BD and MDD remains inconclusive. This study investigates the potential of premorbid Intelligence Quotient (IQ) and school failure frequency as risk factors for Bipolar Disorder (BD) and Major Depressive Disorder (MDD) in a birth cohort setting. We analyze data from the Pelotas population-based birth cohort study, comprising 3580 participants aged 22, who had no prior mood disorder diagnoses. Utilizing regression models and accounting for potential confounders, we assess the impact of IQ and school failure, measured at age 18, on the emergence of BD and MDD diagnoses at age 22, using individuals without mood disorders as comparators. Results reveal that lower IQ (below 70) at 18 is associated with an increased risk of BD (Adjusted Odds Ratio [AOR] 1.75, 95%CI: 1.00-3.09, p < 0.05), while higher IQ (above 120) is linked to MDD (AOR 2.16, 95%CI: 1.24-3.75, p < 0.001). Moreover, an elevated number of school failures is associated with increased BD risk (AOR 1.23, 95%CI: 1.11-1.41, p < 0.001), particularly for BD type 1 (AOR 1.36, 95% CI: 1.17-1.58, p < 0.001). These findings offer insights into the distinct premorbid intellectual characteristics of BD and MDD and contribute to a deeper understanding of their developmental trajectories, potentially informing the development of risk assessment tools for mood disorders.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2023.11.018</identifier><identifier>PMID: 38039690</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Bipolar Disorder - diagnosis ; Bipolar Disorder - epidemiology ; Cohort Studies ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - epidemiology ; Humans ; Intelligence ; Schools ; Young Adult</subject><ispartof>Journal of psychiatric research, 2024-01, Vol.169, p.160-165</ispartof><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c260t-26dd996bf9f3e6fc7884d468da1d4d9a3fd7c0781f949b0f507e65734fa63f573</cites><orcidid>0000-0001-7137-1747 ; 0000-0001-6017-2734</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38039690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rabelo-da-Ponte, Francisco Diego</creatorcontrib><creatorcontrib>Marchionatti, Lauro Estivalete</creatorcontrib><creatorcontrib>Watts, Devon</creatorcontrib><creatorcontrib>Roza, Thiago Henrique</creatorcontrib><creatorcontrib>Amoretti, Silvia</creatorcontrib><creatorcontrib>Barros, Fernando C</creatorcontrib><creatorcontrib>Wehrmeister, Fernando C</creatorcontrib><creatorcontrib>Gonçalves, Helen</creatorcontrib><creatorcontrib>B Menezes, Ana Maria</creatorcontrib><creatorcontrib>Kunz, Maurício</creatorcontrib><creatorcontrib>Kapczinski, Flávio</creatorcontrib><creatorcontrib>Passos, Ives Cavalcante</creatorcontrib><title>Premorbid intelligence quotient and school failure as risk markers for bipolar disorder and major depressive disorder</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Mood disorders significantly impact global health, with MDD ranking as the second leading cause of disability in the United States and BD ranking 18th. Despite their prevalence and impact, the relationship between premorbid intelligence and the subsequent development of BD and MDD remains inconclusive. This study investigates the potential of premorbid Intelligence Quotient (IQ) and school failure frequency as risk factors for Bipolar Disorder (BD) and Major Depressive Disorder (MDD) in a birth cohort setting. We analyze data from the Pelotas population-based birth cohort study, comprising 3580 participants aged 22, who had no prior mood disorder diagnoses. Utilizing regression models and accounting for potential confounders, we assess the impact of IQ and school failure, measured at age 18, on the emergence of BD and MDD diagnoses at age 22, using individuals without mood disorders as comparators. Results reveal that lower IQ (below 70) at 18 is associated with an increased risk of BD (Adjusted Odds Ratio [AOR] 1.75, 95%CI: 1.00-3.09, p < 0.05), while higher IQ (above 120) is linked to MDD (AOR 2.16, 95%CI: 1.24-3.75, p < 0.001). Moreover, an elevated number of school failures is associated with increased BD risk (AOR 1.23, 95%CI: 1.11-1.41, p < 0.001), particularly for BD type 1 (AOR 1.36, 95% CI: 1.17-1.58, p < 0.001). These findings offer insights into the distinct premorbid intellectual characteristics of BD and MDD and contribute to a deeper understanding of their developmental trajectories, potentially informing the development of risk assessment tools for mood disorders.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Cohort Studies</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Humans</subject><subject>Intelligence</subject><subject>Schools</subject><subject>Young Adult</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtO5jAMhSM0CH4ur4CyZNPiNP1zWSIEAxISLGAdpY0DKW1TkhaJt6cMl1nZks-xfT5CKIOSARNnXdlN-b19DglzWUHFS8ZKYGqHbJiSumBc6j9kA1BVBddbsU8Ocu4AQFas3iP7XAHXQsOGLPcJh5ia4GgYZ-z78IRji_R1iXPAcaZ2dDS3zzH21NvQLwmpzTSF_EIHm14wZepjok2YYm8TdSHH5DD98w22W0cOp_XNHN7wd3pEdr3tMx5_10PyeHX5cHFd3N79vbk4vy3aSsBcVMI5rUXjtecofCuVql0tlLPM1U5b7p1sQSrmda0b8FuQKLaS194K7tfmkJx-7Z1SfF0wz2YIuV1T2hHjkk2ltFAga8ZWqfqStinmnNCbKYU14bthYD6hm878h24-oRvGzAp9tZ58X1maAd2v8Ycy_wArEISB</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Rabelo-da-Ponte, Francisco Diego</creator><creator>Marchionatti, Lauro Estivalete</creator><creator>Watts, Devon</creator><creator>Roza, Thiago Henrique</creator><creator>Amoretti, Silvia</creator><creator>Barros, Fernando C</creator><creator>Wehrmeister, Fernando C</creator><creator>Gonçalves, Helen</creator><creator>B Menezes, Ana Maria</creator><creator>Kunz, Maurício</creator><creator>Kapczinski, Flávio</creator><creator>Passos, Ives Cavalcante</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7137-1747</orcidid><orcidid>https://orcid.org/0000-0001-6017-2734</orcidid></search><sort><creationdate>202401</creationdate><title>Premorbid intelligence quotient and school failure as risk markers for bipolar disorder and major depressive disorder</title><author>Rabelo-da-Ponte, Francisco Diego ; Marchionatti, Lauro Estivalete ; Watts, Devon ; Roza, Thiago Henrique ; Amoretti, Silvia ; Barros, Fernando C ; Wehrmeister, Fernando C ; Gonçalves, Helen ; B Menezes, Ana Maria ; Kunz, Maurício ; Kapczinski, Flávio ; Passos, Ives Cavalcante</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c260t-26dd996bf9f3e6fc7884d468da1d4d9a3fd7c0781f949b0f507e65734fa63f573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Cohort Studies</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Humans</topic><topic>Intelligence</topic><topic>Schools</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rabelo-da-Ponte, Francisco Diego</creatorcontrib><creatorcontrib>Marchionatti, Lauro Estivalete</creatorcontrib><creatorcontrib>Watts, Devon</creatorcontrib><creatorcontrib>Roza, Thiago Henrique</creatorcontrib><creatorcontrib>Amoretti, Silvia</creatorcontrib><creatorcontrib>Barros, Fernando C</creatorcontrib><creatorcontrib>Wehrmeister, Fernando C</creatorcontrib><creatorcontrib>Gonçalves, Helen</creatorcontrib><creatorcontrib>B Menezes, Ana Maria</creatorcontrib><creatorcontrib>Kunz, Maurício</creatorcontrib><creatorcontrib>Kapczinski, Flávio</creatorcontrib><creatorcontrib>Passos, Ives Cavalcante</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rabelo-da-Ponte, Francisco Diego</au><au>Marchionatti, Lauro Estivalete</au><au>Watts, Devon</au><au>Roza, Thiago Henrique</au><au>Amoretti, Silvia</au><au>Barros, Fernando C</au><au>Wehrmeister, Fernando C</au><au>Gonçalves, Helen</au><au>B Menezes, Ana Maria</au><au>Kunz, Maurício</au><au>Kapczinski, Flávio</au><au>Passos, Ives Cavalcante</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premorbid intelligence quotient and school failure as risk markers for bipolar disorder and major depressive disorder</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2024-01</date><risdate>2024</risdate><volume>169</volume><spage>160</spage><epage>165</epage><pages>160-165</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Mood disorders significantly impact global health, with MDD ranking as the second leading cause of disability in the United States and BD ranking 18th. 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| subjects | Adolescent Adult Bipolar Disorder - diagnosis Bipolar Disorder - epidemiology Cohort Studies Depressive Disorder, Major - diagnosis Depressive Disorder, Major - epidemiology Humans Intelligence Schools Young Adult |
| title | Premorbid intelligence quotient and school failure as risk markers for bipolar disorder and major depressive disorder |
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