Evaluation of the impact of tragacanth/xanthan gum interpolymer complexation with chitosan on pharmaceutical performance of gels with secnidazole as potential periodontal treatment

•Polyelectrolyte complexes-based hydrogels with secnidazole were developed.•Lyophilization of hydrogels allowed for detailed physicochemical characterization.•Pros and cons of chitosan incorporation were highlighted.•Hydrogels with 5 % secnidazole were selected as optimal for periodontal therapy. Pe...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2024-01, Vol.192, p.106657-106657, Article 106657
Hauptverfasser:	Potaś, Joanna, Wach, Radosław A., Rokita, Bożena, Wróblewska, Magdalena, Winnicka, Katarzyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Chitosan Endothelial Cells Humans Hydrogels Metronidazole - pharmacology Oromucosal hydrogel Periodontitis Secnidazole Tragacanth Xanthan gum
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