Dose-dependent renoprotective effect of vanillic acid on methotrexate-induced nephrotoxicity via its anti-apoptosis, antioxidant, and anti-inflammatory properties

Methotrexate-induced nephrotoxicity is a medical emergency which is associated with a variety of side effects. Vanillic acid (VA), as an antioxidant, removes free radical oxygen to protect cell defense. Therefore, this study investigated VA’s beneficial effects on nephrotoxicity induced by methotrex...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024-06, Vol.397 (6), p.4195-4204
Hauptverfasser:	Amini, Negin, Shoshtari, Mahla Hassanzadeh, Nejaddehbashi, Fereshteh, Dianat, Mahin, Badavi, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antimetabolites, Antineoplastic - toxicity Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein Bcl-x protein Biomedical and Life Sciences Biomedicine Caspase-3 Creatinine Creatinine - blood Dose-Response Relationship, Drug GA-binding protein Inflammation Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - drug therapy Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Lymphocytes B Male Methotrexate Methotrexate - toxicity mRNA Neurosciences NF-E2-Related Factor 2 - metabolism Oxidative Stress - drug effects Pharmacology/Toxicology Rats Rats, Wistar Renal function Vanillic acid Vanillic Acid - pharmacology Vanillic Acid - therapeutic use
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