Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

Squalene synthase (SQS) is an essential enzyme in the mevalonate pathway, which controls cholesterol biosynthesis and homeostasis. Although catalytic inhibitors of SQS have been developed, none have been approved for therapeutic use so far. Herein we sought to develop SQS degraders using targeted pr...

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Veröffentlicht in:	Chemical science (Cambridge) 2023-11, Vol.14 (45), p.12973-12983
Hauptverfasser:	Hoock, Joseph G. F, Rossetti, Cecilia, Bilgin, Mesut, Depta, Laura, Enemark-Rasmussen, Kasper, Christianson, John C, Laraia, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Cholesterol Degradation Homeostasis Ligands
Online-Zugang:	Volltext
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