Cytotoxic and Antifungal Staurosporine Derivatives from Marine‐Derived Actinomycete Streptomyces sp. ZS‐A121

A novel staurosporine derivate, streptomholyrine A (1), along with 6 known compounds were identified from the rice‐based solid fermentation of marine‐derived Streptomyces sp. ZS‐A121. The planar structure and absolute configuration of streptomholyrine A were elucidated using a combination of 1D, 2D...

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Veröffentlicht in:	Chemistry & biodiversity 2024-02, Vol.21 (2), p.e202301712-n/a
Hauptverfasser:	Xu, Lei, Liu, Renshuang, Fang, Jiebin, Zhang, Ningjing, Pu, Fanqi, Lei, Zhen, Ding, Wanjing, Jiang, Yongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Absolute configuration Actinobacteria Antifungal agents Antifungal Agents - metabolism Antifungal Agents - pharmacology antimicrobial Antineoplastic Agents - chemistry Cell lines Cytotoxicity Data analysis ECD and NMR calculations Fermentation Fungicides Humans marine Streptomyces Molecular Structure NMR Nuclear magnetic resonance Planar structures Staurosporine Staurosporine - metabolism Staurosporine - pharmacology streptomholyrine A Streptomyces Streptomyces - chemistry Two dimensional analysis
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