A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics

Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on...

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Veröffentlicht in:	Nature reviews. Drug discovery 2024-01, Vol.23 (1), p.1-2
Hauptverfasser:	Meyer, Miriam, Mahr, Andrea, Brewer, Joanna, Daniel, Volker, Dell‘Aringa, Justine, Goldstone, Tony, Hersey, Sarah, Johnston, Ian, Larson, Pamela, Loveridge, Michael, MacBeath, Gavin, Moyer, Mark, Nagorsen, Dirk, Papa, Sophie, Peiser, Leanne, Ranade, Koustubh, Rizzi, Ruben, Roers, Axel, Schendel, Dolores, Sivakumar, Pallavur, Tran, Eric, Türeci, Özlem, Weigand, Luise, Wennborg, Anders, Williams, Dennis, Yee, Cassian, Britten, Cedrik M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine Biotechnology Cancer Research Comment Histocompatibility Testing Humans Immunotherapy - standards Medicinal Chemistry Molecular Medicine Pharmacology/Toxicology Receptors, Antigen, T-Cell
Online-Zugang:	Volltext
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