A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics
Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on...
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| Veröffentlicht in: | Nature reviews. Drug discovery 2024-01, Vol.23 (1), p.1-2 |
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| creator | Meyer, Miriam Mahr, Andrea Brewer, Joanna Daniel, Volker Dell‘Aringa, Justine Goldstone, Tony Hersey, Sarah Johnston, Ian Larson, Pamela Loveridge, Michael MacBeath, Gavin Moyer, Mark Nagorsen, Dirk Papa, Sophie Peiser, Leanne Ranade, Koustubh Rizzi, Ruben Roers, Axel Schendel, Dolores Sivakumar, Pallavur Tran, Eric Türeci, Özlem Weigand, Luise Wennborg, Anders Williams, Dennis Yee, Cassian Britten, Cedrik M. |
| description | Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.
Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics. |
| doi_str_mv | 10.1038/d41573-023-00189-4 |
| format | Article |
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Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.</description><identifier>ISSN: 1474-1776</identifier><identifier>ISSN: 1474-1784</identifier><identifier>EISSN: 1474-1784</identifier><identifier>DOI: 10.1038/d41573-023-00189-4</identifier><identifier>PMID: 38030734</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biomedicine ; Biotechnology ; Cancer Research ; Comment ; Histocompatibility Testing ; Humans ; Immunotherapy - standards ; Medicinal Chemistry ; Molecular Medicine ; Pharmacology/Toxicology ; Receptors, Antigen, T-Cell</subject><ispartof>Nature reviews. Drug discovery, 2024-01, Vol.23 (1), p.1-2</ispartof><rights>Springer Nature Limited 2023</rights><rights>Springer Nature Limited 2023.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ebd59b75004fdaa27c398afc2b63b72a6c480e16c2055e73d3b42ce35687a2d33</citedby><cites>FETCH-LOGICAL-c375t-ebd59b75004fdaa27c398afc2b63b72a6c480e16c2055e73d3b42ce35687a2d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/d41573-023-00189-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/d41573-023-00189-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38030734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyer, Miriam</creatorcontrib><creatorcontrib>Mahr, Andrea</creatorcontrib><creatorcontrib>Brewer, Joanna</creatorcontrib><creatorcontrib>Daniel, Volker</creatorcontrib><creatorcontrib>Dell‘Aringa, Justine</creatorcontrib><creatorcontrib>Goldstone, Tony</creatorcontrib><creatorcontrib>Hersey, Sarah</creatorcontrib><creatorcontrib>Johnston, Ian</creatorcontrib><creatorcontrib>Larson, Pamela</creatorcontrib><creatorcontrib>Loveridge, Michael</creatorcontrib><creatorcontrib>MacBeath, Gavin</creatorcontrib><creatorcontrib>Moyer, Mark</creatorcontrib><creatorcontrib>Nagorsen, Dirk</creatorcontrib><creatorcontrib>Papa, Sophie</creatorcontrib><creatorcontrib>Peiser, Leanne</creatorcontrib><creatorcontrib>Ranade, Koustubh</creatorcontrib><creatorcontrib>Rizzi, Ruben</creatorcontrib><creatorcontrib>Roers, Axel</creatorcontrib><creatorcontrib>Schendel, Dolores</creatorcontrib><creatorcontrib>Sivakumar, Pallavur</creatorcontrib><creatorcontrib>Tran, Eric</creatorcontrib><creatorcontrib>Türeci, Özlem</creatorcontrib><creatorcontrib>Weigand, Luise</creatorcontrib><creatorcontrib>Wennborg, Anders</creatorcontrib><creatorcontrib>Williams, Dennis</creatorcontrib><creatorcontrib>Yee, Cassian</creatorcontrib><creatorcontrib>Britten, Cedrik M.</creatorcontrib><title>A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics</title><title>Nature reviews. Drug discovery</title><addtitle>Nat Rev Drug Discov</addtitle><addtitle>Nat Rev Drug Discov</addtitle><description>Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.
Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.</description><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cancer Research</subject><subject>Comment</subject><subject>Histocompatibility Testing</subject><subject>Humans</subject><subject>Immunotherapy - standards</subject><subject>Medicinal Chemistry</subject><subject>Molecular Medicine</subject><subject>Pharmacology/Toxicology</subject><subject>Receptors, Antigen, T-Cell</subject><issn>1474-1776</issn><issn>1474-1784</issn><issn>1474-1784</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMtKAzEUhoMoWi8v4EICbtyM5jrJLEvxBgU3dR0ymTN1SjsZk8zCtze1VcGFi5BAvv-cnw-hS0puKeH6rhFUKl4Qlg-huirEAZpQoURBlRaHP29VnqDTGFcZKqlix-iEa8KJ4mKCFlPs7HqNk8e2sUPC6Q1wgOW4tqnzPfYtfppPcYKYun6JWx_wAjvIiQAOhuRDUdsIzTYX7ABj6lw8R0etXUe42N9n6PXhfjF7KuYvj8-z6bxwXMlUQN3IqlaSENE21jLleKVt61hd8loxWzqhCdDSMSIlKN7wWjAHXJZaWdZwfoZudnOH4N_HXNFsurgtZ3vwYzRMV1JRommZ0es_6MqPoc_tDKtodiFZuaXYjnLBxxigNUPoNjZ8GErM1rnZOTfZuflybkQOXe1Hj_UGmp_It-QM8B0Q81e_hPC7-5-xnxh5iqY</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Meyer, Miriam</creator><creator>Mahr, Andrea</creator><creator>Brewer, Joanna</creator><creator>Daniel, Volker</creator><creator>Dell‘Aringa, Justine</creator><creator>Goldstone, Tony</creator><creator>Hersey, Sarah</creator><creator>Johnston, Ian</creator><creator>Larson, Pamela</creator><creator>Loveridge, Michael</creator><creator>MacBeath, Gavin</creator><creator>Moyer, Mark</creator><creator>Nagorsen, Dirk</creator><creator>Papa, Sophie</creator><creator>Peiser, Leanne</creator><creator>Ranade, Koustubh</creator><creator>Rizzi, Ruben</creator><creator>Roers, Axel</creator><creator>Schendel, Dolores</creator><creator>Sivakumar, Pallavur</creator><creator>Tran, Eric</creator><creator>Türeci, Özlem</creator><creator>Weigand, Luise</creator><creator>Wennborg, Anders</creator><creator>Williams, Dennis</creator><creator>Yee, Cassian</creator><creator>Britten, Cedrik M.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20240101</creationdate><title>A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics</title><author>Meyer, Miriam ; 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Drug discovery</jtitle><stitle>Nat Rev Drug Discov</stitle><addtitle>Nat Rev Drug Discov</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>23</volume><issue>1</issue><spage>1</spage><epage>2</epage><pages>1-2</pages><issn>1474-1776</issn><issn>1474-1784</issn><eissn>1474-1784</eissn><abstract>Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.
Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion diagnostics development, despite the invariant nature of the HLA genotype and availability of robust clinical HLA tests. This increases the burden on patients and the organizations developing these products. We propose regulatory flexibility to facilitate the development of and access to TCR-based therapeutics.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38030734</pmid><doi>10.1038/d41573-023-00189-4</doi><tpages>2</tpages></addata></record> |
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| subjects | Biomedicine Biotechnology Cancer Research Comment Histocompatibility Testing Humans Immunotherapy - standards Medicinal Chemistry Molecular Medicine Pharmacology/Toxicology Receptors, Antigen, T-Cell |
| title | A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics |
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