Evaluation the -174G>C Genetic Polymorphism of Interleukin-6 in Iranian Patients with Chronic Lymphocytic Leukemia

Background & ObjectiveInterleukin-6 (IL-6) is involved in inflammation and has a significant role in chronic lymphocytic leukemia (CLL) progression. Accordingly, IL-6 level may increase in CLL-affected patients compared to healthy individuals. The -174G>C single nucleotide polymorphism (SNP)...

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Veröffentlicht in:Iranian Journal of Pathology 2023-10, Vol.18 (4), p.392-397
Hauptverfasser: Rostamzadeh Khameneh, Zakieh, Mohammadian, Mahshid, Eishi Oskuie, Ali, Asghari, Rahim, Nemati, Mohadeseh
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container_end_page 397
container_issue 4
container_start_page 392
container_title Iranian Journal of Pathology
container_volume 18
creator Rostamzadeh Khameneh, Zakieh
Mohammadian, Mahshid
Eishi Oskuie, Ali
Asghari, Rahim
Nemati, Mohadeseh
description Background & ObjectiveInterleukin-6 (IL-6) is involved in inflammation and has a significant role in chronic lymphocytic leukemia (CLL) progression. Accordingly, IL-6 level may increase in CLL-affected patients compared to healthy individuals. The -174G>C single nucleotide polymorphism (SNP) in IL-6 promoter region has been related to differences in IL-6 transcription. Therefore, we investigated the possible association of IL-6 polymorphism with CLL.MethodsWe examined the -174G>C SNP in IL-6 gene and studied its possible relationship with CLL in affected patients and in healthy controls using Amplification Refractory Mutation System- polymerase chain reaction genotyping method. IL-6 plasma level was measured in both studied groups.ResultsAccording to the results, IL-6 mean plasma concentration was increased significantly in the CLL patients compared to the controls. However, 174G>C genotype of the IL-6 gene was not associated with CLL. Furthermore, there were no significant differences in the distribution of allele and genotype frequencies between the CLL-affected patients and the controls (P>0.05).ConclusionOur study showed that -174G>C SNP in promotor of IL-6 gene could not be considered a risk factor for CLL. Larger prospective studies should be performed to confirm our results.
doi_str_mv 10.30699/ijp.2023.544600.2790
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Accordingly, IL-6 level may increase in CLL-affected patients compared to healthy individuals. The -174G&gt;C single nucleotide polymorphism (SNP) in IL-6 promoter region has been related to differences in IL-6 transcription. Therefore, we investigated the possible association of IL-6 polymorphism with CLL.MethodsWe examined the -174G&gt;C SNP in IL-6 gene and studied its possible relationship with CLL in affected patients and in healthy controls using Amplification Refractory Mutation System- polymerase chain reaction genotyping method. IL-6 plasma level was measured in both studied groups.ResultsAccording to the results, IL-6 mean plasma concentration was increased significantly in the CLL patients compared to the controls. However, 174G&gt;C genotype of the IL-6 gene was not associated with CLL. Furthermore, there were no significant differences in the distribution of allele and genotype frequencies between the CLL-affected patients and the controls (P&gt;0.05).ConclusionOur study showed that -174G&gt;C SNP in promotor of IL-6 gene could not be considered a risk factor for CLL. 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Accordingly, IL-6 level may increase in CLL-affected patients compared to healthy individuals. The -174G&gt;C single nucleotide polymorphism (SNP) in IL-6 promoter region has been related to differences in IL-6 transcription. Therefore, we investigated the possible association of IL-6 polymorphism with CLL.MethodsWe examined the -174G&gt;C SNP in IL-6 gene and studied its possible relationship with CLL in affected patients and in healthy controls using Amplification Refractory Mutation System- polymerase chain reaction genotyping method. IL-6 plasma level was measured in both studied groups.ResultsAccording to the results, IL-6 mean plasma concentration was increased significantly in the CLL patients compared to the controls. However, 174G&gt;C genotype of the IL-6 gene was not associated with CLL. Furthermore, there were no significant differences in the distribution of allele and genotype frequencies between the CLL-affected patients and the controls (P&gt;0.05).ConclusionOur study showed that -174G&gt;C SNP in promotor of IL-6 gene could not be considered a risk factor for CLL. 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Accordingly, IL-6 level may increase in CLL-affected patients compared to healthy individuals. The -174G&gt;C single nucleotide polymorphism (SNP) in IL-6 promoter region has been related to differences in IL-6 transcription. Therefore, we investigated the possible association of IL-6 polymorphism with CLL.MethodsWe examined the -174G&gt;C SNP in IL-6 gene and studied its possible relationship with CLL in affected patients and in healthy controls using Amplification Refractory Mutation System- polymerase chain reaction genotyping method. IL-6 plasma level was measured in both studied groups.ResultsAccording to the results, IL-6 mean plasma concentration was increased significantly in the CLL patients compared to the controls. However, 174G&gt;C genotype of the IL-6 gene was not associated with CLL. Furthermore, there were no significant differences in the distribution of allele and genotype frequencies between the CLL-affected patients and the controls (P&gt;0.05).ConclusionOur study showed that -174G&gt;C SNP in promotor of IL-6 gene could not be considered a risk factor for CLL. Larger prospective studies should be performed to confirm our results.</abstract><doi>10.30699/ijp.2023.544600.2790</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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title Evaluation the -174G>C Genetic Polymorphism of Interleukin-6 in Iranian Patients with Chronic Lymphocytic Leukemia
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